Featured Publications
Mechanism of Insulin Action
White M. Mechanism of Insulin Action. 2024, 111-127. DOI: 10.1002/9781119697473.ch9.Peer-Reviewed Original ResearchReceptor tyrosine kinasesTyrosine kinaseGrowth factor signalingSecrete sufficient insulinDysregulated insulin signalingPancreatic beta cellsMuscle insulin resistanceEnvironmental signalsSignal transductionInsulin signalingMuscle-specific deletionSystemic insulin actionSystemic insulin resistanceAdequate insulin responseFactor signalingInsulin-like growth factor signalingPlasma membraneInsulin resistanceInsulin receptorLigand bindingBeta cellsMetabolic stressChronic insulin resistanceGlucose transportTransphosphorylation
1996
Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product.
Uddin S, Yetter A, Katzav S, Hofmann C, White M, Platanias L. Insulin-like growth factor-1 induces rapid tyrosine phosphorylation of the vav proto-oncogene product. Experimental Hematology 1996, 24: 622-7. PMID: 8605967.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Cycle ProteinsCell LineHumansInsulin Receptor Substrate ProteinsInsulin-Like Growth Factor IIntracellular Signaling Peptides and ProteinsMicePhosphoproteinsPhosphorylationPhosphotyrosineProtein-Tyrosine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-vavSignal TransductionConceptsSrc homology 2 domainVav proto-oncogene productGuanine exchange factorAntiphosphotyrosine monoclonal antibodyProto-oncogene productInsulin-like growth factor 1 receptorIGF-1 stimulationGrowth factor 1 receptorHematopoietic cell proliferationFactor 1 receptorExchange factorSH3 domainTyrosine phosphorylationPhosphorylation statusLigand bindingMediate signalsHematopoietic cellsImmunoblotting experimentsHematopoietic originCell proliferationCell linesHuman myeloma cell linesMyeloma cell linesCellsPhosphorylation