2017
Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy
Naganawa M, Gallezot JD, Rossano S, Carson RE. Quantitative PET Imaging in Drug Development: Estimation of Target Occupancy. Bulletin Of Mathematical Biology 2017, 81: 3508-3541. PMID: 29230702, DOI: 10.1007/s11538-017-0374-2.Peer-Reviewed Original Research
2014
Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist PF-04455242
Naganawa M, Jacobsen LK, Zheng MQ, Lin SF, Banerjee A, Byon W, Weinzimmer D, Tomasi G, Nabulsi N, Grimwood S, Badura LL, Carson RE, McCarthy TJ, Huang Y. Evaluation of the agonist PET radioligand [11C]GR103545 to image kappa opioid receptor in humans: Kinetic model selection, test–retest reproducibility and receptor occupancy by the antagonist PF-04455242. NeuroImage 2014, 99: 69-79. PMID: 24844744, PMCID: PMC4140089, DOI: 10.1016/j.neuroimage.2014.05.033.Peer-Reviewed Original ResearchConceptsKappa-opioid receptorsTest-retest reproducibilityTest-retest variabilityAbsolute test-retest variabilityPF-04455242Time-activity curvesIntra-class coefficientOpioid receptorsRegional time-activity curvesMetabolite-corrected arterial input functionHuman positron emission tomography studiesPositron emission tomography studySelective KOR antagonistEmission tomography studiesReceptor occupancy studiesSuitable reference regionHalf maximal inhibitory concentrationAgonist tracersRegional VTAgonist PET radioligandOral doseKOR antagonistsMaximal inhibitory concentrationOral administrationPreclinical models
2005
Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis
Naganawa M, Kimura Y, Ishii K, Oda K, Ishiwata K, Matani A. Extraction of a plasma time-activity curve from dynamic brain PET images based on independent component analysis. IEEE Transactions On Biomedical Engineering 2005, 52: 201-210. PMID: 15709657, DOI: 10.1109/tbme.2004.840193.Peer-Reviewed Original ResearchConceptsBrain PET imagesIndependent component analysisVolume imagesDynamic PET imagesPET imagesDynamic positron emission tomography (PET) dataAppropriate preprocessingBlood volume imagesImagesComponent analysisObjective functionPositron emission tomography dataComputer simulationsBrain FDG-PET studiesTomography dataPlasma time-activity curvePreprocessingNew methodEmission tomography dataSerial arterial blood samplingModelInput functionExtraction