2024
T32. GENETIC ARCHITECTURE OF BIPOLAR SPECTRUM DISORDERS IN NEARLY 102,000 LATINO ANCESTRY INDIVIDUALS
Bigdeli T, Voloudakis G, Chatzinakos C, Barr P, Gorman B, Peterson R, Pyarajan S, Huang G, Gaziano M, Pato M, Fanous A, Pato C, Aslan M, Roussos P, Harvey P. T32. GENETIC ARCHITECTURE OF BIPOLAR SPECTRUM DISORDERS IN NEARLY 102,000 LATINO ANCESTRY INDIVIDUALS. European Neuropsychopharmacology 2024, 87: 173-174. DOI: 10.1016/j.euroneuro.2024.08.342.Peer-Reviewed Original ResearchGenome-wide association studiesPolygenic risk scoresEuropean ancestryMillion Veteran ProgramAdmixed AmericansGenomic Psychiatry CohortGenome-wide association study analysisGenome-wide significant signalsMulti-ancestry meta-analysisLocal ancestry inferenceStatistical fine-mappingBipolar disorderCooperative Studies ProgramGenomic structural equation modelingLatino individualsAncestry inferencePRS-CSxTrans-diagnostic approachBipolar spectrum disordersEast Asian populationsFine-mappingAssociation studiesGWAS statisticsPsychiatric genetic researchAncestry individuals
2023
88. GENETIC ARCHITECTURE OF SCHIZOPHRENIA IN AFRICAN ANCESTRY INDIVIDUALS
Bigdeli T, Gorman B, Voloudakis G, Chatzinakos C, Barr P, Burstein D, Genovese G, Pyarajan S, Huang G, Pato C, Pato M, Fanous A, Aslan M, Harvey P, Roussos P. 88. GENETIC ARCHITECTURE OF SCHIZOPHRENIA IN AFRICAN ANCESTRY INDIVIDUALS. European Neuropsychopharmacology 2023, 75: s103. DOI: 10.1016/j.euroneuro.2023.08.191.Peer-Reviewed Original ResearchAfrican ancestry individualsAllelic effectsMillion Veteran ProgramFine-mapping resolutionGenome-wide significanceNew biological insightsDuplication eventsGenetic architectureGenomic methodologiesAncestry tractsIndex SNPsSingle locusPhenotypic dataGenetic analysisBiological insightsMHC lociAfrican diaspora populationsAfrican ancestryLociChromosome 6p21Genetic effectsGenetic researchEast Asian populationsLarge-scale research initiativesHuman population