2023
Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans
Kirk F, Munk D, Swenson E, Quicquaro A, Vendelbo M, Schilsky M, Ott P, Sandahl T. Effects of trientine and penicillamine on intestinal copper uptake: A mechanistic 64Cu PET/CT study in healthy humans. Hepatology 2023, 79: 1065-1074. PMID: 38088886, PMCID: PMC11019997, DOI: 10.1097/hep.0000000000000708.Peer-Reviewed Original ResearchUrinary copper excretionStandard uptake valueIntestinal copper absorptionUptake valueCopper excretionIntestinal absorptionPositron emission tomography/CT scanMean standard uptake valueSame therapeutic targetsPET/CT studiesVenous blood samplesCopper absorptionIntestinal copper uptakeEffects of drugsUrinary excretionCT scanHealthy volunteersBlood samplesHealthy humansTrientineTherapeutic targetBody weightCT studiesWilson's diseaseD-penicillamine
2009
Chapter 42 Wilson Disease and the Kidney
Schilsky M, Mistry P. Chapter 42 Wilson Disease and the Kidney. 2009, 709-713. DOI: 10.1016/b978-0-12-449851-8.00042-5.Peer-Reviewed Original ResearchLiver failureWilson's diseaseRenal injuryLower urine sodium excretionD-penicillamineDevelopment of oliguriaChronic liver failureUrine sodium excretionInitiation of therapyAcute liver failureYears of therapyCopper-chelating drugHepatic copper accumulationHepatorenal syndromeBiliary copper excretionLupus nephritisRenal dysfunctionSodium excretionTubular injuryRenal toxicityUrinary excretionRenal clearanceTubular defectsUrinary sedimentHigh incidence