2012
Proteome-wide Analysis of Lysine Acetylation Suggests its Broad Regulatory Scope in Saccharomyces cerevisiae *
Henriksen P, Wagner SA, Weinert BT, Sharma S, Bačinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Proteome-wide Analysis of Lysine Acetylation Suggests its Broad Regulatory Scope in Saccharomyces cerevisiae *. Molecular & Cellular Proteomics 2012, 11: 1510-1522. PMID: 22865919, PMCID: PMC3494197, DOI: 10.1074/mcp.m112.017251.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationConserved SequenceEvolution, MolecularIonsLysineMolecular Sequence AnnotationNuclear ProteinsProtein TransportProteomeProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsConceptsAcetylation sitesLysine acetylationS. cerevisiaeUnicellular eukaryotic model organismBudding yeast Saccharomyces cerevisiaeRegulatory roleBroader regulatory scopeProtein synthesisEukaryotic model organismYeast Saccharomyces cerevisiaePost-translational modificationsLysine acetylation sitesImportant regulatory roleChromatin organizationLysine acetyltransferasesModel organismsWide analysisPutative substratesRegulatory domainCritical regulatory domainsHistone H2BAcetylated proteinsProtein foldingSaccharomyces cerevisiaeBioinformatics analysis
2011
Eisosome-driven plasma membrane organization is mediated by BAR domains
Ziółkowska NE, Karotki L, Rehman M, Huiskonen JT, Walther TC. Eisosome-driven plasma membrane organization is mediated by BAR domains. Nature Structural & Molecular Biology 2011, 18: 854-856. PMID: 21685922, DOI: 10.1038/nsmb.2080.Peer-Reviewed Original ResearchMeSH KeywordsCell MembraneMembrane ProteinsMultigene FamilyPhosphoproteinsPhylogenyProtein Structure, TertiarySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSequence Analysis, Protein
2010
A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking
Aguilar PS, Fröhlich F, Rehman M, Shales M, Ulitsky I, Olivera-Couto A, Braberg H, Shamir R, Walter P, Mann M, Ejsing CS, Krogan NJ, Walther TC. A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking. Nature Structural & Molecular Biology 2010, 17: 901-908. PMID: 20526336, PMCID: PMC3073498, DOI: 10.1038/nsmb.1829.Peer-Reviewed Original ResearchMeSH KeywordsCell MembraneEndocytosisEndosomesGenes, FungalMembrane ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSphingolipidsConceptsGDP/GTP exchange factorQuantitative genetic interaction mapGenetic interaction mapSphingolipid metabolismGTP exchange factorExchange factorMotif analysisEndosomal traffickingMembrane biologyInteraction mapEisosomesE-MAPGenesRom2MetabolismRho1New componentsTraffickingBiologyRegulationRhO2UncoversIdentification
2009
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions. Science 2009, 325: 834-840. PMID: 19608861, DOI: 10.1126/science.1175371.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAmino Acid MotifsBenzamidesCell Line, TumorCell NucleusCell Physiological PhenomenaCytoplasmEnzyme InhibitorsHistone Deacetylase InhibitorsHistone DeacetylasesHumansHydroxamic AcidsLysineMass SpectrometryMetabolic Networks and PathwaysMitochondriaMultiprotein ComplexesProtein Processing, Post-TranslationalProtein Structure, TertiaryProteinsProteomeProteomicsPyridinesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVorinostatConceptsLysine acetylationCellular rolesPosttranslational modificationsCyclin-dependent kinase Cdc28Phosphorylation-dependent interactionReversible posttranslational modificationDiverse cellular processesMajor cellular functionsTarget protein complexesMajor posttranslational modificationLarge macromolecular complexesLysine acetylation sitesChromatin remodelingActin nucleationNuclear transportProtein complexesCellular functionsCellular processesAcetylation sitesMacromolecular complexesAcetylation changesGene expressionCell cycleDeacetylase inhibitorsAcetylation