2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Urea NitrogenGlomerular Filtration RateKidney DiseasesKidney GlomerulusMiceMice, KnockoutMyosin Type IMyosinsPodocytesConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1977
Renal cortical blood flow distribution in obstructive nephropathy in rats.
Siegel N, Feldman R, Lytton B, Hayslett J, Kashgarian M. Renal cortical blood flow distribution in obstructive nephropathy in rats. Circulation Research 1977, 40: 379-384. PMID: 844151, DOI: 10.1161/01.res.40.4.379.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood Urea NitrogenDiuresisGlomerular Filtration RateIschemiaKidney CortexMaleRatsRegional Blood FlowTime FactorsUreteral ObstructionConceptsCortical blood flow distributionBilateral ureteral occlusionUnilateral ureteral occlusionRenal blood flowGlomerular filtration rateOuter cortical perfusionBlood flow distributionCortical perfusionObstructive nephropathyUreteral occlusionRenal cortical blood flow distributionRelease of obstructionIntrarenal hemodynamicsCortical ischemiaUUO ratsRapid normalizationFiltration ratePostobstructive diuresisBlood flowComplete returnRapid returnObstructionRatsNormal patternNephropathy
1975
Minimal-lesion nephrotic syndrome with early resistance to steroid therapy
Siegel N, Gur A, Krassner L, Kashgarian M. Minimal-lesion nephrotic syndrome with early resistance to steroid therapy. The Journal Of Pediatrics 1975, 87: 377-380. PMID: 1165516, DOI: 10.1016/s0022-3476(75)80639-1.Peer-Reviewed Original ResearchConceptsMinimal lesion nephrotic syndromeNephrotic syndromeLong-term clinical courseEarly resistanceMinimal glomerular lesionsClinical courseSteroid responsivenessClinical outcomesPrompt remissionCyclophosphamide treatmentGlomerular lesionsHistopathologic lesionsPatientsRemissionCyclophosphamideSyndromeTherapyLesionsUltimate outcomeOutcomesChildrenCorticosteroidsPrednisoneRelapseSteroids
1974
Compensatory adaptation of structure and function following progressive renal ablation
Kaufman J, DiMeola H, Siegel N, Lytton B, Kashgarian M, Hayslett J. Compensatory adaptation of structure and function following progressive renal ablation. Kidney International 1974, 6: 10-17. PMID: 4419711, DOI: 10.1038/ki.1974.72.Peer-Reviewed Original ResearchConceptsRenal ablationRenal tissueNephron glomerular filtration rateCompensatory adaptationGlomerular filtration rateClearance of inulinRenal insufficiencyUninephrectomized ratsFour-week intervalsFiltration rateRenal massesGroup BGroup AControl animalsGroup CLE ratsFunctional changesMass of tissueSegmental lossRatsSurgeryAdaptive changesAblationClearanceTissue
1972
THE EFFECT OF AZATHIOPRINE ON LUPUS GLOMERULONEPHRITIS
HAYSLETT J, KASHGARIAN M, COOK C, SPARGO B. THE EFFECT OF AZATHIOPRINE ON LUPUS GLOMERULONEPHRITIS. Medicine 1972, 51: 393. PMID: 4115512, DOI: 10.1097/00005792-197209000-00004.Peer-Reviewed Original ResearchCLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA
Hendler E, Kashgarian M, Hayslett J. CLINICOPATHOLOGICAL CORRELATIONS OF PRIMARY HÆMATURIA. The Lancet 1972, 299: 458-463. PMID: 4109816, DOI: 10.1016/s0140-6736(72)90121-3.Peer-Reviewed Original ResearchConceptsRenal diseaseProliferative glomerulonephritisPathological lesionsMild proliferative glomerulonephritisUrinary tract lesionsUrinary protein excretionGroup of patientsTypes of glomerulonephritisSevere proliferative glomerulonephritisType of lesionIntercurrent infectionRenal functionRenal biopsyProtein excretionPrimary lesionClinicopathological correlationDistribution of ageCorrect diagnosisPatientsGlomerulonephritisLesionsYoung adultsDiseaseHæmorrhageUseful index
1970
Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat
Luke R, Warren Y, Kashgarian M, Levitin H. Effects of Chloride Restriction and Depletion on Acid-Base Balance and Chloride Conservation in the Rat. Clinical Science 1970, 38: 385-396. PMID: 5442558, DOI: 10.1042/cs0380385.Peer-Reviewed Original ResearchConceptsUrinary net acid excretionNet acid excretionAcid excretionPlasma bicarbonateProximal tubulesBicarbonate absorptionDietary chloride restrictionProximal tubular absorptionUrinary acid excretionEndogenous acid productionLow chloride dietDegree of elevationAcid-base balanceDietary sodiumPlasma chlorideSerum bicarbonateTubular absorptionPhosphate excretionRespiratory acidosisMicropuncture experimentsDepleted ratsHypochloraemiaRatsExcretionRates of sodium