2008
Disruption of Myosin 1e Promotes Podocyte Injury
Krendel M, Kim SV, Willinger T, Wang T, Kashgarian M, Flavell RA, Mooseker MS. Disruption of Myosin 1e Promotes Podocyte Injury. Journal Of The American Society Of Nephrology 2008, 20: 86-94. PMID: 19005011, PMCID: PMC2615733, DOI: 10.1681/asn.2007111172.Peer-Reviewed Original ResearchConceptsChronic renal injuryNormal glomerular filtrationGlomerular basement membraneRenal injuryKidney inflammationPodocyte foot processesGlomerular diseasePodocyte injuryGlomerular filtrationRenal tissueFoot processesPodocyte functionBasement membraneInjuryUltrastructural levelDiseaseMiceType IProteinuriaInflammationKidneyImportant rolePodocytes
1998
Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia
Aufricht C, Ardito T, Thulin G, Kashgarian M, Siegel N, Van Why S. Heat-shock protein 25 induction and redistribution during actin reorganization after renal ischemia. American Journal Of Physiology 1998, 274: f215-f222. PMID: 9458842, DOI: 10.1152/ajprenal.1998.274.1.f215.Peer-Reviewed Original ResearchConceptsHSP-25Renal ischemiaHeat shock protein 25Ischemic renal injuryH reflowRat renal cortexControl proximal tubulesRenal injuryPostischemic recoveryRenal cortexIschemiaProximal tubulesIntracytoplasmic accumulationPeak levelsHeat shock proteinsProtein 25Actin stainingInsoluble cytoskeletal fractionPunctate accumulationsCytoskeletal disruptionSmall heat shock proteinsRegulatory roleInductionIntracellular distributionCytoskeletal fraction
1993
Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.
Soifer N, Van Why S, Ganz M, Kashgarian M, Siegel N, Stewart A. Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia. Journal Of Clinical Investigation 1993, 92: 2850-2857. PMID: 8254039, PMCID: PMC288486, DOI: 10.1172/jci116905.Peer-Reviewed Original ResearchMeSH KeywordsActinsAmino Acid IsomerasesAnimalsBlotting, NorthernCarrier ProteinsGene ExpressionImmunohistochemistryIschemiaKidneyKidney GlomerulusKidney TubulesMaleParathyroid Hormone-Related ProteinPeptidylprolyl IsomeraseProtein BiosynthesisProteinsRatsRats, Sprague-DawleyReceptors, Parathyroid HormoneReference ValuesRenal ArteryReperfusionRNA, MessengerConceptsHormone-related proteinMesangial cellsTubular cellsAcute renal ischemic injuryBilateral renal artery occlusionMale Sprague-Dawley ratsParathyroid hormone-related proteinAutocrine/paracrine fashionPTHrP mRNA levelsRenal artery occlusionRenal ischemic injuryMRNA levelsSprague-Dawley ratsDistal tubular cellsSham-operated animalsCyclophilin mRNA levelsProximal tubular cellsLocalization of PTHrPCultured mesangial cellsLocal growth factorsAdult rat kidneyArtery occlusionGlomerular epithelial cellsRenal injuryIschemic injury
1992
Induction and intracellular localization of HSP-72 after renal ischemia
Van Why S, Hildebrandt F, Ardito T, Mann A, Siegel N, Kashgarian M. Induction and intracellular localization of HSP-72 after renal ischemia. American Journal Of Physiology 1992, 263: f769-f775. PMID: 1443167, DOI: 10.1152/ajprenal.1992.263.5.f769.Peer-Reviewed Original ResearchConceptsHSP 72Renal ischemiaHeat shock proteinsIschemic renal injuryMin of reperfusionProtein elaborationHSP mRNA expressionHSP-70 mRNARenal injuryIschemic injuryTransient ischemiaProximal tubulesIschemiaRat kidneyMRNA expressionIntracellular localizationMRNA inductionInjuryTubule morphologyImmunofluorescent localizationShock proteinsVesicular patternCellular recoveryHSP proteinsCellular remodeling
1991
Predictors of one year outcome in lupus nephritis: the importance of renal biopsy.
Esdaile J, Federgreen W, Quintal H, Suissa S, Hayslett J, Kashgarian M. Predictors of one year outcome in lupus nephritis: the importance of renal biopsy. QJM 1991, 81: 907-18. PMID: 1808631.Peer-Reviewed Original ResearchConceptsLupus nephritisRenal biopsyBiopsy variablesHigher activity index scoreDiffuse proliferative lupus nephritisSubepithelial electron-dense depositsDiffuse proliferative nephritisActivity index scoreProliferative lupus nephritisShort-term prognosisTime of biopsyClinical predictive modelClinical prediction modelElectron-dense depositsTubulointerstitial scoresNew predictive informationRenal injurySerum creatinineGroups of subjectsLaboratory predictorsPlatelet countUnivariate analysisClinical signsYear outcomesIndividual patientsPredictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy
ESDAILE J, FEDERGREEN W, QUINTAL H, SUISSA S, HAYSLETT J, KASHGARIAN M. Predictors of One Year Outcome in Lupus Nephritis: The Importance of Renal Biopsy. QJM 1991, 81: 907-918. DOI: 10.1093/oxfordjournals.qjmed.a068639.Peer-Reviewed Original ResearchLupus nephritisRenal biopsySerum creatinineClinical prediction modelBiopsy variablesPrognosis of lupus nephritisDiffuse proliferative lupus nephritisProliferative lupus nephritisDiffuse proliferative nephritisTime of biopsySubepithelial electron-dense depositsActivity index scoreShort-term prognosisBiopsy informationLaboratory predictorsPlatelet countRenal injuryTubulointerstitial scoresProliferative nephritisUnivariate analysisElectron-dense depositsBiopsyCoexisting illnessesNephritisUrinary protein
1986
Postischemic hemodynamics and recovery of renal adenosine triphosphate
Gaudio K, Stromski M, Thulin G, Ardito T, Kashgarian M, Siegel N. Postischemic hemodynamics and recovery of renal adenosine triphosphate. American Journal Of Physiology 1986, 251: f603-f609. PMID: 3490185, DOI: 10.1152/ajprenal.1986.251.4.f603.Peer-Reviewed Original ResearchConceptsRenal blood flowIschemic acute renal injuryImportant pathophysiological componentRenal ATP levelsAcute renal injuryInfusion of dopamineSaline-treated ratsPostischemic enhancementRenal adenosineRenal vasoconstrictionRenal injuryTubular functionPathophysiological componentPostischemic infusionInulin clearanceATP-MgCl2Vasoactive compoundsTubular epitheliumBlood flowPharmacological agentsPostischemic hemodynamicsTubular cellsSaline ratsEnhances recoveryRatsNo aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats.
Stein H, Sterzel R, Hunt J, Pabst R, Kashgarian M. No aggravation of the course of experimental glomerulonephritis in spontaneously hypertensive rats. American Journal Of Pathology 1986, 122: 520-30. PMID: 3513602, PMCID: PMC1888211.Peer-Reviewed Original ResearchMeSH KeywordsAlbuminuriaAnimalsAntibodies, Anti-IdiotypicAntibody FormationAutoradiographyBlood PressureFluorescent Antibody TechniqueGlomerulonephritisHistocytochemistryHypertensionImmune System DiseasesImmunoglobulin GKidneyMaleMicroscopy, ElectronRabbitsRatsRats, Inbred SHRRats, Inbred WKYThymidineConceptsWistar-Kyoto controlsBlood pressureGBM nephritisRenal injurySystemic hypertensionHypertensive ratsNormotensive Wistar-Kyoto (WKY) controlsAntiglomerular basement membrane nephritisUrinary albumin excretionSystolic blood pressureIgG antibody productionHumoral antibody responseNonspecific esteraseLight microscopyAlbumin excretionAutoregulatory capacityControl SHRMild hypertensionMorphologic injuryCreatinine clearanceGlomerular alterationsSerum creatinineNSE stainingHumoral responseAntibody response
1984
Beneficial effect of thyroxin on recovery from toxic acute renal failure
Siegel N, Gaudio K, Katz L, Reilly H, Ardito T, Hendler F, Kashgarian M. Beneficial effect of thyroxin on recovery from toxic acute renal failure. Kidney International 1984, 25: 906-911. PMID: 6471672, DOI: 10.1038/ki.1984.108.Peer-Reviewed Original ResearchConceptsToxic acute renal failureAcute renal failureNormal salineRenal failureBeneficial effectsInjected ratsOnly normal salineT4-treated ratsEffect of thyroxinNonspecific systemic effectsT4-treated animalsRenal insultHemodynamic effectsRenal functionRenal injuryControl ratsGlomerular functionUrine flowSimilar doseSystemic effectsEnhanced recoveryPrompt recoveryKidney preparationRatsFENa
1983
Accelerated cellular recovery after an ischemic renal injury.
Gaudio K, Ardito T, Reilly H, Kashgarian M, Siegel N. Accelerated cellular recovery after an ischemic renal injury. American Journal Of Pathology 1983, 112: 338-46. PMID: 6604459, PMCID: PMC1916386.Peer-Reviewed Original ResearchConceptsProximal tubular pressureCellular morphologic featuresRenal ischemiaATP-MgCl2Back leakTubular integrityMorphologic featuresCellular damageIschemic cellular damageProgressive ischemic injurySevere ischemic damageIschemic renal injurySaline-treated ratsGroups of ratsEarly regenerative changesRenal injuryIschemic damageIschemic injuryIschemic alterationsNormal salineRegenerative changesSaline ratsEnhances recoverySalutary effectsHistomorphometric analysis
1981
Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion
Siegel N, Upadhyaya K, Kashgarian M. Inhibition by indomethacin of adaptive changes in the contralateral kidney after release of unilateral ureteral occlusion. Kidney International 1981, 20: 691-694. PMID: 7334741, DOI: 10.1038/ki.1981.197.Peer-Reviewed Original ResearchConceptsUnilateral ureteral occlusionBilateral ureteral occlusionContralateral kidneyUreteral occlusionRenal functionAdaptive changesCompensatory changesObstructive renal injuryInfusion of indomethacinRelease of obstructionRenal hemodynamicsRenal injuryPattern of recoveryObstructive nephropathyPathophysiologic alterationsRenal massesUnoperated kidneysKidneyOcclusionAdaptive alterationsHemodynamicsControl organsIndomethacinAlterationsPresent study
1980
ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2
Siegel N, Taylor M, Gaudio K, Chaudry I, Kashgarian M. ISCHEMIC ACUTE RENAL FAILURE: DELAYED INFUSION OF ATP-MGCL2. Pediatric Research 1980, 14: 1017-1017. DOI: 10.1203/00006450-198008000-00262.Peer-Reviewed Original ResearchMinutes of ischemiaATP-MgCl2Normal salineIschemic insultBilateral renal artery occlusionModerate ischemic insultRenal artery occlusionInfusion of ATPDelayed infusionRenal injuryArtery occlusionIschemic injuryRenal ischemiaInitial injuryInitial insultInulin clearanceInjuryIschemiaInfusionInsultCINAnimalsMinutesHoursPrevious studiesEnhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats
Siegel N, Glazier W, Chaudry I, Gaudio K, Lytton B, Baue A, Kashgarian M. Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats. Kidney International 1980, 17: 338-349. PMID: 7401453, DOI: 10.1038/ki.1980.39.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal injuryRenal failureAcute renal injuryIschemic renal injuryAdenine nucleotidesFocal cellular necrosisElevated FENaRenal insultIschemic kidneyIschemic periodTubular functionAcute insultNonischemic kidneysPostischemic infusionFunctional impairmentTubular cellsDegree of improvementCellular necrosisRatsInfusionCINUltrastructural changesUltrastructural studyFENa
1978
Enhanced recovery from severe ischemic renal injury with adenosine triphosphate-magnesium chloride: administration after the insult.
Glazier W, Chaudry I, Siegel N, Kashgarian M, Lytton B, Baue A. Enhanced recovery from severe ischemic renal injury with adenosine triphosphate-magnesium chloride: administration after the insult. Journal Of The American College Of Surgeons 1978, 29: 82-4. PMID: 401294.Peer-Reviewed Original Research
1977
RENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION
Siegel N, Gunatream S, Kashgarian M. RENAL BLOOD FLOW AND GLOMERULAR PERFUSION DURING URETERAL OCCLUSION. Pediatric Research 1977, 11: 557-557. DOI: 10.1203/00006450-197704000-01125.Peer-Reviewed Original ResearchRenal blood flowGlomerular perfusionUreteral occlusionSuperficial cortexBlood flowObstructive nephropathyTotal renal blood flowBilateral ureteral occlusionRadioactive microsphere techniqueSham operated control animalsGlomerular hypoperfusionCortical ischemiaOperated control animalsCortical perfusionRenal injuryComplete ureteral occlusionMicrosphere techniqueSham operationControl animalsDeep cortexPerfusionControl valuesGlomerular countCortexOcclusion