2024
Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization
Vafaii H, Mandino F, Desrosiers-Grégoire G, O’Connor D, Markicevic M, Shen X, Ge X, Herman P, Hyder F, Papademetris X, Chakravarty M, Crair M, Constable R, Lake E, Pessoa L. Multimodal measures of spontaneous brain activity reveal both common and divergent patterns of cortical functional organization. Nature Communications 2024, 15: 229. PMID: 38172111, PMCID: PMC10764905, DOI: 10.1038/s41467-023-44363-z.Peer-Reviewed Original Research
2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2020
Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics
Cardin JA, Crair MC, Higley MJ. Mesoscopic Imaging: Shining a Wide Light on Large-Scale Neural Dynamics. Neuron 2020, 108: 33-43. PMID: 33058764, PMCID: PMC7577373, DOI: 10.1016/j.neuron.2020.09.031.Peer-Reviewed Original ResearchTransverse sinus injections drive robust whole-brain expression of transgenes
Hamodi AS, Sabino A, Fitzgerald ND, Moschou D, Crair M. Transverse sinus injections drive robust whole-brain expression of transgenes. ELife 2020, 9: e53639. PMID: 32420870, PMCID: PMC7266618, DOI: 10.7554/elife.53639.Peer-Reviewed Original Research
2019
Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits
Barson D, Hamodi AS, Shen X, Lur G, Constable RT, Cardin JA, Crair MC, Higley MJ. Simultaneous mesoscopic and two-photon imaging of neuronal activity in cortical circuits. Nature Methods 2019, 17: 107-113. PMID: 31686040, PMCID: PMC6946863, DOI: 10.1038/s41592-019-0625-2.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptide-expressing interneuronsBrain-wide network dynamicsTwo-photon calcium imagingEntire cortical mantleLocal neuronal circuitsLong-range cortical networksWidespread gene deliveryWidefield calciumPyramidal neuronsAwake miceCortical circuitsNeuronal activityCortical mantleTwo-photon imagingViral transduction methodsNeuronal circuitsCalcium imagingMouse brainFunctional connectivityLocal microcircuitsMammalian cortexCortical architectureCortical networksBrainActivity propagates
2016
Reconnecting Eye to Brain
Crair MC, Mason CA. Reconnecting Eye to Brain. Journal Of Neuroscience 2016, 36: 10707-10722. PMID: 27798125, PMCID: PMC5083002, DOI: 10.1523/jneurosci.1711-16.2016.Peer-Reviewed Original ResearchConceptsAudacious Goals InitiativeNational Eye InstituteRetinal ganglion cellsSystem regenerationEye InstituteGanglion cellsVisual functionTraumatic injuryVisual system functionNeural regenerationTarget engagementDisease-induced degenerationRegenerative capacityVisual systemAxon guidanceSystem functionSignificant barriersCurrent understandingSatellite meetingInjuryAxonsDegenerationNeuronsBrain
2013
Role of emergent neural activity in visual map development
Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Current Opinion In Neurobiology 2013, 24: 166-175. PMID: 24492092, PMCID: PMC3957181, DOI: 10.1016/j.conb.2013.11.011.Peer-Reviewed Original ResearchConceptsRetinal wavesNeural activitySpontaneous activityNormal visual functionOnset of visionVisual functionGestational periodCalcium influxFunctional visionLong gestational periodNervous systemVisual circuitsNeurotransmitter releaseNerve cellsAssociative circuitsCircuit connectivitySensory-motor systemEye openingFunctional developmentVisuomotor learningSpecific spatiotemporal patternsSpontaneous patternsExcitable cellsOnsetFuture studies
2005
A Digital Atlas to Characterize the Mouse Brain Transcriptome
Carson JP, Ju T, Lu HC, Thaller C, Xu M, Pallas SL, Crair MC, Warren J, Chiu W, Eichele G. A Digital Atlas to Characterize the Mouse Brain Transcriptome. PLOS Computational Biology 2005, 1: e41. PMID: 16184189, PMCID: PMC1215388, DOI: 10.1371/journal.pcbi.0010041.Peer-Reviewed Original ResearchConceptsDigital atlasUser queriesQuery patternsAnnotation methodData modalitiesMassive amountsTypes of dataExpression patternsMouse brain transcriptomeGene expression patternsComputational methodsCommon framePostnatal mouse brainBrain transcriptomeQueriesCandidate genesComplex tissuesCellular resolutionGenes
1999
Neuronal activity during development: permissive or instructive?
Crair M. Neuronal activity during development: permissive or instructive? Current Opinion In Neurobiology 1999, 9: 88-93. PMID: 10072369, DOI: 10.1016/s0959-4388(99)80011-7.Peer-Reviewed Original Research