2021
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Guo X, Zhou J, Starr C, Mohns EJ, Li Y, Chen EP, Yoon Y, Kellner CP, Tanaka K, Wang H, Liu W, Pasquale LR, Demb JB, Crair MC, Chen B. Preservation of vision after CaMKII-mediated protection of retinal ganglion cells. Cell 2021, 184: 4299-4314.e12. PMID: 34297923, PMCID: PMC8530265, DOI: 10.1016/j.cell.2021.06.031.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainCalcium-Calmodulin-Dependent Protein Kinase Type 2Cyclic AMP Response Element-Binding ProteinCytoprotectionDependovirusDisease Models, AnimalEnzyme ActivationGlaucomaMice, Inbred C57BLNeurotoxinsOptic Nerve InjuriesRetinal Ganglion CellsSignal TransductionVision, OcularConceptsRetinal ganglion cellsRGC survivalRGC somataGanglion cellsDiverse insultsRGC axon projectionOptic nerve injurySole output neuronsPreservation of visionElevated intraocular pressureIrreversible vision lossPathological statesExcitotoxic injuryNerve injuryGlaucoma modelIntraocular pressureRGC axonsVision lossVisual functionNormal retinaVisual cortexAxon projectionsGenetic deficiencyInjuryRetina
2016
Reconnecting Eye to Brain
Crair MC, Mason CA. Reconnecting Eye to Brain. Journal Of Neuroscience 2016, 36: 10707-10722. PMID: 27798125, PMCID: PMC5083002, DOI: 10.1523/jneurosci.1711-16.2016.Peer-Reviewed Original ResearchConceptsAudacious Goals InitiativeNational Eye InstituteRetinal ganglion cellsSystem regenerationEye InstituteGanglion cellsVisual functionTraumatic injuryVisual system functionNeural regenerationTarget engagementDisease-induced degenerationRegenerative capacityVisual systemAxon guidanceSystem functionSignificant barriersCurrent understandingSatellite meetingInjuryAxonsDegenerationNeuronsBrain