Discovery and pre-clinical development of antithrombotics from hematophagous invertebrates.
Ledizet M, Harrison LM, Koskia RA, Cappello M. Discovery and pre-clinical development of antithrombotics from hematophagous invertebrates. Cardiovascular & Hematological Agents In Medicinal Chemistry 2005, 3: 1-10. PMID: 15638739, DOI: 10.2174/1568016052773315.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAncylostomatoideaAnimalsAnticoagulantsBiological ProductsBlood Coagulation Factor InhibitorsDrug Evaluation, PreclinicalFibrinolytic AgentsHumansInvertebratesLeechesPlatelet Aggregation InhibitorsThrombosisTicksConceptsNumerous invertebrate speciesHematophagous invertebratesInvertebrate speciesSpecific inhibitorUnique specificityInvertebratesFunctional strategiesCritical roleImpressive arrayActivation of thrombosisUseful therapeutic agentPre-clinical developmentNatural productsInhibitorsPlatelet inhibitorsHeart diseaseHuman illnessPlatelet functionClinical developmentSpeciesTherapeutic agentsAntithromboticsParasitesBloodmealThrombosis