2023
Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally
Bobba P, Weber C, Malhotra A, Bahtiyar M, Copel J, Taylor S, Ment L, Payabvash S. Early brain microstructural development among preterm infants requiring caesarean section versus those delivered vaginally. Scientific Reports 2023, 13: 21514. PMID: 38057452, PMCID: PMC10700578, DOI: 10.1038/s41598-023-48963-z.Peer-Reviewed Original Research
2019
Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation
Irani RA, Buhimschi CS, Cross SN, Zhao G, Copel JA, Bhandari V, Buhimschi IA, Bahtiyar MO. Fetal Myocardial Function as Assessed by N-Terminal Fragment Brain Natriuretic Protein in Premature Fetuses Exposed to Intra-amniotic Inflammation. American Journal Of Perinatology 2019, 37: 745-753. PMID: 31121635, DOI: 10.1055/s-0039-1688909.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidBiomarkersChorioamnionitisEchocardiography, DopplerFemaleFetal BloodFetal HeartHumansInfant, NewbornInfant, PrematureInflammationInterleukin-6MaleMass SpectrometryNatriuretic Peptide, BrainPeptide FragmentsPlacentaPregnancyPremature BirthVentricular Function, LeftConceptsIntra-amniotic infection/inflammationBrain natriuretic proteinAmniotic fluidNT-proBNPTei indexNatriuretic proteinVentricular functionFetal exposureCord bloodCord IL-6Intra-amniotic inflammationFetal myocardial functionInfection/inflammationBlood NT-proBNPFetal heart functionNT-proBNP immunoassaysEnzyme-linked immunosorbentGestational agePremature fetusesFetal echocardiogramIL-6Circulatory levelsMyocardial functionHeart functionFetuses
2018
In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence
Bahtiyar MO, Ekmekci E, Demirel E, Irani RA, Copel JA. In utero Partial Exchange Transfusion Combined with in utero Blood Transfusion for Prenatal Management of Twin Anemia-Polycythemia Sequence. Fetal Diagnosis And Therapy 2018, 45: 28-35. PMID: 29533957, DOI: 10.1159/000486198.Peer-Reviewed Original ResearchConceptsTwin anemia-polycythemia sequencePlacental vascular connectionsBlood transfusionTwin-twin transfusion syndromePartial exchange transfusionMonochorionic twin pregnanciesVascular connectionsFetoscopic laser photocoagulationLimited outcome dataAbsence of polyhydramniosAnemic twinPlacental territoryTAPS casesDonor twinRecipient twinPlacental sharingTransfusion syndromeChronic anemiaTwin pregnanciesDangerous complicationExchange transfusionPlacental vesselsUnique complicationsLaser photocoagulationPrenatal treatment
2016
Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes
Archabald KL, Buhimschi IA, Bahtiyar MO, Dulay AT, Abdel-Razeq SS, Pettker CM, Lipkind HS, Hardy JT, McCarthy ME, Zhao G, Bhandari V, Buhimschi CS. Limiting the Exposure of Select Fetuses to Intrauterine Infection/Inflammation Improves Short-Term Neonatal Outcomes in Preterm Premature Rupture of Membranes. Fetal Diagnosis And Therapy 2016, 42: 99-110. PMID: 27794570, PMCID: PMC11588317, DOI: 10.1159/000450997.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNeonatal outcomesPremature ruptureEarly deliveryIntrauterine infection/inflammationSetting of PPROMAdverse neonatal outcomesAmniotic fluid infectionPreterm premature ruptureShort-term outcomesInfection/inflammationIntra-amniotic infectionTerm neonatal outcomesSelect fetusesAntenatal exposureExpectant managementSingleton newbornsHospital dischargeNeonatal sepsisHaptoglobin-related proteinNewborn's riskFluid infectionGestational ageAdverse outcomesSelect subgroup
2015
Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis
Dulay AT, Buhimschi IA, Zhao G, Bahtiyar MO, Thung SF, Cackovic M, Buhimschi CS. Compartmentalization of acute phase reactants Interleukin-6, C-Reactive Protein and Procalcitonin as biomarkers of intra-amniotic infection and chorioamnionitis. Cytokine 2015, 76: 236-243. PMID: 25957466, PMCID: PMC4824401, DOI: 10.1016/j.cyto.2015.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidAsymptomatic InfectionsBiomarkersCalcitoninCalcitonin Gene-Related PeptideChorioamnionitisC-Reactive ProteinFemaleFetal BloodFetal Membranes, Premature RuptureHumansInfant, NewbornInterleukin-6Obstetric Labor, PrematurePlacentaPregnancyPregnancy Complications, InfectiousPremature BirthProtein PrecursorsSystemic Inflammatory Response SyndromeConceptsIntra-amniotic infectionC-reactive proteinSubclinical intra-amniotic infectionIL-6Blood IL-6 levelsBlood IL-6Maternal blood levelsSystemic inflammatory responseIL-6 levelsNon-invasive biomarkersSubgroup of casesChorioamnionitis groupHistological chorioamnionitisInflammatory markersPreterm laborCRP levelsInflammatory biomarkersMaternal serumPlacental pathologyAcute phasePregnant womenBlood levelsSubclinical phaseInterleukin-6Cord blood
2012
Evaluating the cost‐effectiveness of prenatal surgery for myelomeningocele: a decision analysis
Werner E, Han C, Burd I, Lipkind H, Copel J, Bahtiyar M, Thung S. Evaluating the cost‐effectiveness of prenatal surgery for myelomeningocele: a decision analysis. Ultrasound In Obstetrics And Gynecology 2012, 40: 158-164. PMID: 22511529, DOI: 10.1002/uog.11176.Peer-Reviewed Original ResearchConceptsPrenatal myelomeningocele repairQuality-adjusted life yearsMyelomeningocele repairPostnatal repairMyelomeningocele patientsPrenatal surgeryAdditional casesLong-term medical careFuture pregnancy complicationsIncremental cost-effectiveness ratioPostnatal myelomeningocele repairCost-effectiveness ratioDecision analysis modelingUterine ruptureNeurologic deficitsPregnancy complicationsSingleton gestationsSurgery resultsLife yearsMedical carePatientsCost-effective strategyNormal karyotypeNeonatesSurgery
2011
IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes
Lee SY, Buhimschi IA, Dulay AT, Ali UA, Zhao G, Abdel-Razeq SS, Bahtiyar MO, Thung SF, Funai EF, Buhimschi CS. IL-6 Trans-Signaling System in Intra-Amniotic Inflammation, Preterm Birth, and Preterm Premature Rupture of the Membranes. The Journal Of Immunology 2011, 186: 3226-3236. PMID: 21282511, PMCID: PMC3800180, DOI: 10.4049/jimmunol.1003587.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmniocentesisAmniotic FluidCytokine Receptor gp130FemaleFetal Membranes, Premature RuptureHumansInfant, NewbornInfant, PrematureInflammation MediatorsInterleukin-6Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsPregnancyPregnancy ComplicationsPremature BirthReceptors, Interleukin-6Signal TransductionYoung AdultConceptsIntra-amniotic inflammationSIL-6RIL-6RPremature ruptureIL-6Classic IL-6 signalingAF IL-6RT-PCRPreterm premature ruptureIL-6 signalingMatrix metalloprotease-9Real-time RT-PCRActivation of cellsPhysiologic constituentPreterm laborPreterm birthIL-6 TransGestational ageThird trimesterInflammatory cellsSecond trimesterNormal gestationMetalloprotease-9IL-6 bindsFetal membranes
2010
Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity
Azpurua H, Norwitz ER, Campbell KH, Funai EF, Pettker CM, Kleine M, Bahtiyar MO, Malkus H, Copel JA, Thung SF. Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturity. American Journal Of Obstetrics And Gynecology 2010, 203: 40.e1-40.e8. PMID: 20417479, DOI: 10.1016/j.ajog.2010.01.075.Peer-Reviewed Original ResearchConceptsAcceleration time/ejection time ratioEjection time ratioFetal lung maturityLecithin/sphingomyelin ratioFetal pulmonary arteryLung maturitySphingomyelin ratioPulmonary arteryAcceleration/ejection time ratioPulmonary artery blood flowSystolic/diastolic ratioYale-New Haven HospitalAmniotic fluid biomarkersAmniotic fluid lecithin/sphingomyelin ratioArtery blood flowFlow velocity waveformsFlow velocity parametersNew noninvasive techniqueSingleton pregnanciesDiastolic ratioPulsatility indexUltrasound evaluationFluid biomarkersPotential confoundersStudy criteria
2009
Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth
Azpurua H, Dulay AT, Buhimschi IA, Bahtiyar MO, Funai E, Abdel-Razeq SS, Luo G, Bhandari V, Copel JA, Buhimschi CS. Fetal renal artery impedance as assessed by Doppler ultrasound in pregnancies complicated by intraamniotic inflammation and preterm birth. American Journal Of Obstetrics And Gynecology 2009, 200: 203.e1-203.e11. PMID: 19185102, PMCID: PMC3791328, DOI: 10.1016/j.ajog.2008.11.001.Peer-Reviewed Original ResearchConceptsCord blood IL-6End-diastolic blood flowRenal artery pulsatility indexArtery pulsatility indexBlood IL-6Amniotic fluid indexIntraamniotic inflammationResistance indexPulsatility indexPreterm birthIL-6Blood flowSerum blood urea nitrogen levelAF IL-6 levelsInflammation-associated preterm birthRenal artery resistance indexSystolic/diastolic ratioBlood urea nitrogen levelsAge-reference rangeCord blood interleukinRenal vascular bedIL-6 levelsHours of lifeUrea nitrogen levelsBlood interleukin
2008
Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation
Buhimschi C, Abdel-Razeq S, Cackovic M, Pettker C, Dulay A, Bahtiyar M, Zambrano E, Martin R, Norwitz E, Bhandari V, Buhimschi I. Fetal Heart Rate Monitoring Patterns in Women with Amniotic Fluid Proteomic Profiles Indicative of Inflammation. American Journal Of Perinatology 2008, 25: 359-372. PMID: 18512201, PMCID: PMC2724874, DOI: 10.1055/s-2008-1078761.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisIntra-amniotic inflammationFetal heart rate monitoring patternsHistological chorioamnionitisPreterm birthPredictive valueAcute histological chorioamnionitisFetuses of womenHuman Development criteriaUseful clinical indicatorNegative predictive valuePositive predictive valueMonitoring patternsNeonatal sepsisPremature neonatesGestational ageLaboratory criteriaAntibiotic treatmentClinical indicatorsChild healthSensitive predictorInflammationAdmissionNeonatesInitial evaluationPrenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography
Bahtiyar MO, Dulay AT, Weeks BP, Friedman AH, Copel JA. Prenatal Course of Isolated Muscular Ventricular Septal Defects Diagnosed Only by Color Doppler Sonography. Journal Of Ultrasound In Medicine 2008, 27: 715-720. PMID: 18424646, DOI: 10.7863/jum.2008.27.5.715.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDown SyndromeEchocardiographyFemaleFetal DevelopmentFetal DiseasesFetal HeartFollow-Up StudiesGestational AgeHeart Septal Defects, VentricularHumansInfant, NewbornNuchal Translucency MeasurementPregnancyPregnancy OutcomeProspective StudiesRisk AssessmentTripletsTwinsUltrasonography, Doppler, ColorUltrasonography, PrenatalConceptsVentricular septal defectColor Doppler examinationMuscular VSDDoppler examinationSeptal defectStudy groupIsolated muscular ventricular septal defectTrisomy 21Isolated ventricular septal defectMuscular ventricular septal defectsHigh-resolution ultrasound equipmentCommon congenital heart defectSmall muscular VSDMean gestational ageFetal echocardiographic examinationColor Doppler sonographyCongenital heart defectsPrenatal resolutionTriplet gestationsEchocardiographic examinationGestational ageCounseling patientsPerinatal courseTwin gestationsFirst trimesterNucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis
Dulay AT, Buhimschi IA, Zhao G, Luo G, Abdel-Razeq S, Cackovic M, Rosenberg VA, Pettker CM, Thung SF, Bahtiyar MO, Bhandari V, Buhimschi CS. Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsis. American Journal Of Obstetrics And Gynecology 2008, 198: 426.e1-426.e9. PMID: 18395034, PMCID: PMC4023236, DOI: 10.1016/j.ajog.2008.01.040.Peer-Reviewed Original ResearchConceptsEarly-onset neonatal sepsisNucleated red blood cellsInflammation-associated preterm birthNRBC countAcid-base statusIntraamniotic inflammationHistological chorioamnionitisNeonatal sepsisRed blood cellsPreterm birthGestational ageCord blood IL-6 levelsBlood IL-6 levelsFetal acid-base statusBlood cellsAbsolute NRBC countsIL-6 levelsEarly neonatal periodIntrauterine growth restrictionHours of birthEarlier gestational ageMediators of inflammationMinutes of deliveryAbsence of hypoxiaPreterm singletonsFetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth
Buhimschi CS, Turan OM, Funai EF, Azpurua H, Bahtiyar MO, Turan S, Zhao G, Dulay A, Bhandari V, Copel JA, Buhimschi IA. Fetal Adrenal Gland Volume and Cortisol/Dehydroepiandrosterone Sulfate Ratio in Inflammation-Associated Preterm Birth. Obstetrics And Gynecology 2008, 111: 715-722. PMID: 18310376, DOI: 10.1097/aog.0b013e3181610294.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal GlandsAdultAmniotic FluidBiomarkersChorioamnionitisDehydroepiandrosterone SulfateFemaleFetal BloodHumansHydrocortisoneInfant, NewbornInfant, PrematureInterleukin-6Organ SizePituitary-Adrenal SystemPregnancyPremature BirthSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationUltrasonography, PrenatalConceptsAdrenal gland volumeFetal adrenal gland volumeIntraamniotic inflammationGland volumeInterleukin-6Preterm birthCord blood IL-6 levelsBlood IL-6 levelsCord blood IL-6Blood IL-6IL-6 levelsCortisol/Dehydroepiandrosterone Sulfate RatioPituitary-adrenocortical systemConsecutive singleton fetusesThree-dimensional ultrasonographyAdrenal volumeFetal adaptationGestational ageSteroid exposureFetal cortisolFetal weightSingleton fetusesUterine contractionsAdrenocortical axisDHEA ratio
2006
Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: Analysis of U.S. perinatal mortality data, 1995-1997
Bahtiyar MO, Julien S, Robinson JN, Lumey L, Zybert P, Copel JA, Lockwood CJ, Norwitz ER. Prior cesarean delivery is not associated with an increased risk of stillbirth in a subsequent pregnancy: Analysis of U.S. perinatal mortality data, 1995-1997. American Journal Of Obstetrics And Gynecology 2006, 195: 1373-1378. PMID: 16677588, DOI: 10.1016/j.ajog.2006.02.051.Peer-Reviewed Original ResearchConceptsPrior cesarean deliveryRisk of stillbirthCesarean deliverySubsequent pregnancyPerinatal mortality dataMedical conditionsDemise rateUnexplained intrauterine fetal demiseMortality dataIntrauterine fetal demiseMaternal medical conditionsSingleton term pregnanciesFetal congenital abnormalitiesCesarean delivery rateCross-sectional studySingleton pregnanciesTerm pregnancyFetal demisePrior deliveryPregnant womenMaternal ageCongenital anomaliesStudy groupHaenszel methodCongenital abnormalities