2010
Interpretation of Amniotic Fluid White Blood Cell Count in “Bloody Tap” Amniocenteses in Women With Symptoms of Preterm Labor
Abdel-Razeq SS, Buhimschi IA, Bahtiyar MO, Rosenberg VA, Dulay AT, Han CS, Werner EF, Thung S, Buhimschi CS. Interpretation of Amniotic Fluid White Blood Cell Count in “Bloody Tap” Amniocenteses in Women With Symptoms of Preterm Labor. Obstetrics And Gynecology 2010, 116: 344-354. PMID: 20664395, PMCID: PMC4142228, DOI: 10.1097/aog.0b013e3181e8fec6.Peer-Reviewed Original ResearchConceptsWhite blood cellsAmniotic fluid white blood cellBlood cell countWBC countAmniotic fluidBloody tapAmniotic fluid white blood cell countCell countAmniotic fluid WBC countRBC/White blood cell countPositive amniotic fluid cultureMaternal WBC countRed blood cell countCells/Number of neutrophilsAbsence of inflammationSetting of inflammationAmniotic fluid culturePositive likelihood ratioAmniotic fluid samplesIntraamniotic inflammationPreterm laborConsecutive womenFluid culture
2007
Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis
Buhimschi CS, Bhandari V, Hamar BD, Bahtiyar MO, Zhao G, Sfakianaki AK, Pettker CM, Magloire L, Funai E, Norwitz ER, Paidas M, Copel JA, Weiner CP, Lockwood CJ, Buhimschi IA. Proteomic Profiling of the Amniotic Fluid to Detect Inflammation, Infection, and Neonatal Sepsis. PLOS Medicine 2007, 4: e18. PMID: 17227133, PMCID: PMC1769412, DOI: 10.1371/journal.pmed.0040018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmniocentesisAmniotic FluidBiomarkersFemaleHumansInflammationMiddle AgedPregnancyPregnancy Complications, InfectiousPregnancy OutcomeProteomeProteomicsReproducibility of ResultsSensitivity and SpecificitySepsisSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationConceptsEarly-onset neonatal sepsisAmniotic fluid inflammationIntra-amniotic infectionMR scoreNeonatal sepsisAmniotic fluidHistological chorioamnionitisDelivery intervalNewborn Special Care UnitGram stainEarly-onset sepsisIntra-amniotic inflammationDegree of inflammationSpecial care unitsIntrauterine inflammationPlacental inflammationShorter amniocentesisPreterm deliveryPreterm laborSingleton pregnanciesConsecutive womenPreterm birthCare unitGestational agePremature rupture
2006
A low vaginal “pool” amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes
Buhimschi CS, Sfakianaki AK, Hamar BG, Pettker CM, Bahtiyar MO, Funai E, Norwitz ER, Copel JA, Lockwood CJ, Buhimschi IA. A low vaginal “pool” amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranes. American Journal Of Obstetrics And Gynecology 2006, 194: 309-316. PMID: 16458622, DOI: 10.1016/j.ajog.2005.07.070.Peer-Reviewed Original ResearchConceptsIntra-amniotic infectionPreterm premature rupturePredictive valuePremature ruptureGlucose measurementsCohen's kappa measureGlucose levelsGlucose concentrationIntra-amniotic infection/inflammationEnd of enrollmentInfection/inflammationRed blood cell countBlood cell countPositive microbial culturesNegative AF cultureCharacteristic curve analysisNegative microbial culturesNegative predictive valuePositive predictive valueClinical laboratory analysisKappa measureConsecutive womenNoninfected groupTransabdominal amniocentesisSensitive marker