2010
Imaging Atherosclerosis and Vulnerable Plaque
Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging Atherosclerosis and Vulnerable Plaque. Journal Of Nuclear Medicine 2010, 51: 51s-65s. PMID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisClinical Trials as TopicContrast MediaExtracellular MatrixFerric CompoundsFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingNanoparticlesNeovascularization, PathologicRiskThrombosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsTotal atherosclerotic burdenAcute cardiovascular eventsAtherosclerotic burdenCardiovascular eventsVascular thrombosisPlaque inflammationMyocardial infarctionPlaque stabilityFibrin depositsVulnerable plaquesHigh riskVasa vasorumPlaque evolutionSame imaging sessionVascular imagingVessel wallImaging sessionClinical translationBiologic processesModalitiesAnatomyExtracellular matrix
2009
Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury.
Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 117-23. PMID: 20083860.Peer-Reviewed Original ResearchConceptsMyocardial hypertrophyHypoxic myocardiumMyocardial infarctionRat modelPressure overload-induced myocardial hypertrophyNon-invasive imaging strategyDeficient blood flowDegree of hypoperfusionAbdominal aortic bandingAnterior lateral wallLeft ventricular remodelingIschemic rat modelMarkers of angiogenesisHypoxia-induced angiogenesisPotential clinical useIschemic injuryAortic bandingVentricular remodelingAlphavbeta3 integrin receptorMyocardial hypoxiaImmunohistochemical stainingMyocardial uptakeRodent modelsBlood flowMyocardial segments