2000
Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus
Liang B, Kashgarian M, Sharpe A, Mamula M. Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus. The Journal Of Immunology 2000, 165: 3436-3443. PMID: 10975864, DOI: 10.4049/jimmunol.165.6.3436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntigens, CDAntigens, Differentiation, B-LymphocyteAutoantibodiesB7-1 AntigenB7-2 AntigenBiomarkersComplement C3DNAImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MKidneyLupus NephritisLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearT-LymphocytesConceptsMRL-lpr/lpr miceSystemic lupus erythematosusLpr miceB7-2 costimulationB7-1Autoantibody responseB7-2Murine modelCostimulatory signalsAnti-small nuclear ribonucleoproteinMRL/lpr lupusHuman systemic lupus erythematosusB7-1/B7C3 complement depositionAnti-DNA titersAnti-DNA autoantibodiesWild-type animalsImmunotherapeutic interventionsMemory CD4Lupus erythematosusAutoimmune diseasesAutoimmune pathologyC3 depositsComplement depositionT lymphocytes
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponse
1998
Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens
Santulli-Marotto S, Retter M, Gee R, Mamula M, Clarke S. Autoreactive B Cell Regulation: Peripheral Induction of Developmental Arrest by Lupus-Associated Autoantigens. Immunity 1998, 8: 209-219. PMID: 9492002, DOI: 10.1016/s1074-7613(00)80473-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantigensB-LymphocytesBone MarrowCell DifferentiationDNA, Single-StrandedEnzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueGene Rearrangement, B-Lymphocyte, Heavy ChainHematopoietic Stem CellsHybridomasImmune ToleranceLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, TransgenicRibonucleoproteins, Small NuclearSnRNP Core ProteinsSpleenConceptsB cellsAnti-Sm B cellsAnti-ssDNA antibodiesB-cell phenotypeImmature B-cell phenotypeImmature B cellsAutoreactive cellsMurine lupusPeripheral inductionTolerance inductionVH-D-JH rearrangementsTransgenic miceAnti-Sm hybridomasSplenic repertoireCell phenotypeSpontaneous activationCellsInductionLupusImmunizationAutoantigensLater stagesDevelopmental arrestMiceSecretion