Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination
Radojcic V, Bezak K, Skarica M, Pletneva M, Yoshimura K, Schulick R, Luznik L. Cyclophosphamide resets dendritic cell homeostasis and enhances antitumor immunity through effects that extend beyond regulatory T cell elimination. Cancer Immunology, Immunotherapy 2009, 59: 137-148. PMID: 19590872, PMCID: PMC3103867, DOI: 10.1007/s00262-009-0734-3.Peer-Reviewed Original ResearchConceptsDendritic cell homeostasisAntitumor immunityT cellsLow-dose total body irradiationTumor antigen-specific T cellsAnti-CD25 monoclonal antibodyHematopoietic stem cell supportAntigen-specific T cellsUntreated tumor-bearing animalsTumor-infiltrating DCsExpansion of TregsRegulatory T cellsStem cell supportTotal body irradiationT cell responsesLess IL-10More IL-12Tumor-bearing animalsT cell eliminationCell homeostasisDC turnoverTreg depletionImmunotherapeutic strategiesIL-10Body irradiationSignal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis
Skarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, Whartenby K. Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2009, 182: 4192-4199. PMID: 19299717, PMCID: PMC3727416, DOI: 10.4049/jimmunol.0803631.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisPeripheral dendritic cellsDendritic cellsT cellsSignal transduction inhibitorsAutoimmune encephalomyelitisMultiple sclerosisIFN-gamma-secreting T cellsBone marrow chimera systemAg-specific T cellsTransduction inhibitorsT cell responsesT cell subsetsSignal transduction inhibitionCNS infiltrationCytokine polarizationIL-17IL-23Th1 responseAutoimmune responseCell subsetsCostimulatory moleculesIL-6TNF-alphaCEP-701