2010
Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs
Toscano M, Delgado M, Kong W, Martin F, Skarica M, Ganea D. Dendritic Cells Transduced With Lentiviral Vectors Expressing VIP Differentiate Into VIP-secreting Tolerogenic-like DCs. Molecular Therapy 2010, 18: 1035-1045. PMID: 20068554, PMCID: PMC2890107, DOI: 10.1038/mt.2009.293.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsCell DifferentiationCell MovementCells, CulturedDendritic CellsEnzyme-Linked Immunosorbent AssayFlow CytometryGenetic VectorsLentivirusMiceMice, Inbred BALB CPolymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionTransduction, GeneticVasoactive Intestinal PeptideConceptsVasoactive intestinal peptideExperimental autoimmune encephalomyelitisDendritic cellsTherapeutic effectTolerogenic DCsVIP administrationInflammatory disordersT cellsImmune responseBone marrow-derived dendritic cellsBone marrow-derived DCsMarrow-derived dendritic cellsNeuropeptide vasoactive intestinal peptideTolerogenic dendritic cellsAllogeneic T cellsAutoimmune/inflammatory disordersRegulatory T cellsIL-10 productionProinflammatory cytokine secretionPromising therapeutic toolLentiviral vectorsHigh-dose inoculationCLP miceAutoimmune encephalomyelitisPuncture (CLP) sepsis
2009
Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis
Skarica M, Wang T, McCadden E, Kardian D, Calabresi P, Small D, Whartenby K. Signal Transduction Inhibition of APCs Diminishes Th17 and Th1 Responses in Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2009, 182: 4192-4199. PMID: 19299717, PMCID: PMC3727416, DOI: 10.4049/jimmunol.0803631.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisPeripheral dendritic cellsDendritic cellsT cellsSignal transduction inhibitorsAutoimmune encephalomyelitisMultiple sclerosisIFN-gamma-secreting T cellsBone marrow chimera systemAg-specific T cellsTransduction inhibitorsT cell responsesT cell subsetsSignal transduction inhibitionCNS infiltrationCytokine polarizationIL-17IL-23Th1 responseAutoimmune responseCell subsetsCostimulatory moleculesIL-6TNF-alphaCEP-701