2001
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease
Liu J, Anderson B, Robert M, McNiff J, Emerson S, Shlomchik W, Shlomchik M. Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. Blood 2001, 98: 3367-3375. PMID: 11719376, DOI: 10.1182/blood.v98.12.3367.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCytokinesDisease Models, AnimalFlow CytometryGanciclovirGraft vs Host DiseaseGraft vs Leukemia EffectHematopoiesisHematopoietic Stem CellsInterleukin-2Interleukin-4Lymphocyte SubsetsMaleMiceMice, TransgenicPromoter Regions, GeneticSimplexvirusSpleenThymidine KinaseThymus GlandT-LymphocytesWeight GainConceptsDonor T cellsT cellsT2 cellsGVHD reactionsHost diseaseInterleukin-2Herpes simplex virus thymidine kinase gene transductionAllogeneic stem cell transplantationCytokine-producing T cellsPrevention of GVHDStem cell transplantationReversal of diseaseT cell deletionLater time pointsAcute graftCytokine polarizationOngoing GVHDClinical GVHDAntibody infusionPeak diseaseClinical effectsCell transplantationIL-4 promoterGVHDDeficient mice
1995
PERFORIN AND GRANZYME B
McDiarmid S, Farmer D, Kuniyoshi J, Robert M, Khadavi A, Shaked A, Busuttil R. PERFORIN AND GRANZYME B. Transplantation 1995, 59: 762-766. PMID: 7886805, DOI: 10.1097/00007890-199503150-00021.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceBiomarkersBlotting, SouthernCytokinesGraft RejectionGranzymesIntestine, SmallMembrane GlycoproteinsMolecular Sequence DataPerforinPore Forming Cytotoxic ProteinsRatsRats, Inbred BNRats, Inbred LewRNA, MessengerSerine EndopeptidasesT-Lymphocytes, CytotoxicTransplantation, HomologousUp-RegulationConceptsGranzyme BLewis recipientsAllograft groupIsograft controlsPostoperative day 3Reverse transcriptase-polymerase chain reaction methodSemiquantitative reverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reaction methodReverse transcriptase-polymerase chain reactionTranscriptase-polymerase chain reactionHistologic rejectionPOD 14Transplant allograftsMild rejectionPOD 3POD 5Killer cellsPOD 10Polymerase chain reaction methodHistologic evidenceTransplant rejectionPolymerase chain reactionF1 donorsHistologic evaluationChain reaction method
1994
THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION
McDIARMID S, FARMER D, KUNIYOSHI J, ROBERT M, KHADAVI A, SHAKED A, BUSUTTIL R. THE CORRELATION OF INTRAGRAFT CYTOKINE EXPRESSION WITH REJECTION IN RAT SMALL INTESTINE TRANSPLANTATION. Transplantation 1994, 58: 690-697. PMID: 7940688, DOI: 10.1097/00007890-199409270-00009.Peer-Reviewed Original ResearchConceptsSmall intestine transplantationInterleukin-6Reverse transcriptase-PCRTNF-alphaInterleukin-2IFN-gammaPOD 14POD 3POD 7Cytokine expressionTumor necrosis factor alphaIntragraft cytokine expressionSeverity of rejectionEvidence of rejectionIL-2 receptorNecrosis factor alphaSemiquantitative reverse transcriptase-PCRRat small intestineExpression of mRNAIntestine transplantationGraft lossLewis recipientsHistologic rejectionIntragraft expressionMild rejectionIntragraft cytokine and cytotoxic T lymphocyte (CTL) specific protein expression as predictors of rat small intestine transplant rejection.
McDiarmid S, Farmer D, Kuniyoshi J, Robert M, Khadavi A, Shaked A, Busuttil R. Intragraft cytokine and cytotoxic T lymphocyte (CTL) specific protein expression as predictors of rat small intestine transplant rejection. Transplantation Proceedings 1994, 26: 1520-1. PMID: 8030018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCytokinesGraft RejectionInterferon-gammaInterleukin-2Interleukin-6Intestine, SmallMembrane GlycoproteinsPerforinPolymerase Chain ReactionPore Forming Cytotoxic ProteinsRatsRats, Inbred BNRats, Inbred LewReceptors, Interleukin-2RNA, MessengerSerine EndopeptidasesTime FactorsT-Lymphocytes, CytotoxicTransplantation, HomologousTransplantation, IsogeneicTumor Necrosis Factor-alpha