2016
The reduction in circulating levels of melatonin may be associated with the development of preeclampsia
Zeng K, Gao Y, Wan J, Tong M, Lee A, Zhao M, Chen Q. The reduction in circulating levels of melatonin may be associated with the development of preeclampsia. Journal Of Human Hypertension 2016, 30: 666-671. PMID: 27251079, DOI: 10.1038/jhh.2016.37.Peer-Reviewed Original ResearchConceptsIncidence of preeclampsiaLevels of melatoninDevelopment of preeclampsiaSerum levelsPreeclamptic placentasMelatonin receptorsLate-onset preeclampsiaHealthy pregnant womenPregnancy-specific disorderPathogenesis of preeclampsiaHealthy pregnancyPlacental dysfunctionPregnant womenSuccessful pregnancyPreeclampsiaMelatonin levelsPregnancyIncidenceMelatoninOxidative stressWomenTime onsetPlacentaReceptorsAssociation
2015
An analysis of the differences between early and late preeclampsia with severe hypertension
Li X, Guo P, Xue Y, Gou W, Tong M, Chen Q. An analysis of the differences between early and late preeclampsia with severe hypertension. Pregnancy Hypertension 2015, 6: 47-52. PMID: 26955772, DOI: 10.1016/j.preghy.2015.12.003.Peer-Reviewed Original ResearchConceptsLate-onset preeclampsiaSevere hypertensionLate preeclampsiaEarly preeclampsiaOnset preeclampsiaRenal functionLaboratory biomarkersEarly onsetClinical parametersSubgroups of preeclampsiaDiastolic velocity ratioUniversity Teaching HospitalBlood urea nitrogenTime of deliveryAlkaline phosphatase levelsRenal dysfunctionPerinatal mortalitySevere headacheGestational ageClinical symptomsLiver functionVision disturbancesMaternal ageTeaching hospitalHypertensionSerum uric acid may not be involved in the development of preeclampsia
Chen Q, Lau S, Tong M, Wei J, Shen F, Zhao J, Zhao M. Serum uric acid may not be involved in the development of preeclampsia. Journal Of Human Hypertension 2015, 30: 136-140. PMID: 25994995, DOI: 10.1038/jhh.2015.47.Peer-Reviewed Original ResearchConceptsDevelopment of preeclampsiaSerum levelsSecond trimesterUric acidSeverity of preeclampsiaTime of presentationHigher serum levelsSerum uric acidTime of onsetNormotensive pregnanciesThird trimesterClinical symptomsPregnant womenPreeclampsiaPrediction biomarkersEarly changesRetrospective sampleProspective sampleTrimesterWomenPresentationLess evidenceMeaningful associations