2024
Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies
Chutani A, Guevara-Pineda D, Lerner G, Menon M. Re-Evaluating the Transplant Glomerulopathy Lesion—Beyond Donor-Specific Antibodies. Transplant International 2024, 37: 13365. DOI: 10.3389/ti.2024.13365.Peer-Reviewed Original ResearchTransplant glomerulopathyLonger-term graft survivalCell-mediated immune mechanismsChronic allograft damageNon-HLA antibodiesDonor-specific antibodiesAnti-HLA alloantibodiesChronic allograft dysfunctionPathogenesis of transplant glomerulopathyPost-transplant yearComplement-mediated injuryShort-term outcomesAllograft dysfunctionAllograft damageGraft lossGraft survivalRenal transplantationEtiological diagnosisPodocyte stressHistological manifestationsImmune mechanismsMorphological lesionsGlomerulopathyTransplantationReview article
2022
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial
Hricik D, Armstrong B, Alhamad T, Brennan D, Bromberg J, Bunnapradist S, Chandran S, Fairchild R, Foley D, Formica R, Gibson I, Kesler K, Kim SJ, Mannon R, Menon M, Newell K, Nickerson P, Odim J, Poggio E, Sung R, Shapiro R, Tinckam K, Vincenti F, Heeger P. Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial. Journal Of The American Society Of Nephrology 2022, 34: 145-159. PMID: 36195441, PMCID: PMC10101585, DOI: 10.1681/asn.2022040454.Peer-Reviewed Original ResearchConceptsBiopsy-proven acute rejectionBK virus infectionIntravenous infliximabPrimary end pointTransplant recipientsKidney transplantVirus infectionDe novo donor-specific antibodiesDeceased donor kidney transplant recipientsRabbit anti-thymocyte globulin (rATG) inductionAnti-thymocyte globulin inductionCLINICAL TRIAL REGISTRY NAMEDonor kidney transplant recipientsNovo donor-specific antibodiesEnd pointPhase 2 clinical trialIFX induction therapyTRIAL REGISTRY NAMEDelayed graft functionDonor-specific antibodiesKidney transplant recipientsDeceased donor kidneysTNF-α productionPrimary transplant recipientsAcute rejection