2012
Corrigendum: Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers
Laine L, Kivitz A, Bello A, Grahn A, Schiff M, Taha A. Corrigendum: Double-Blind Randomized Trials of Single-Tablet Ibuprofen/High-Dose Famotidine vs. Ibuprofen Alone for Reduction of Gastric and Duodenal Ulcers. The American Journal Of Gastroenterology 2012, 107: 1272. DOI: 10.1038/ajg.2012.244.Peer-Reviewed Original Research
2009
Prescription rates of protective co‐therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines
LAINE L, CONNORS L, GRIFFIN MR, CURTIS SP, KAUR A, CANNON CP. Prescription rates of protective co‐therapy for NSAID users at high GI risk and results of attempts to improve adherence to guidelines. Alimentary Pharmacology & Therapeutics 2009, 30: 767-774. PMID: 19594486, DOI: 10.1111/j.1365-2036.2009.04090.x.Peer-Reviewed Original ResearchDoes Capsule Endoscopy Improve Outcomes in Obscure GI Bleeding: Randomized Controlled Trial of Capsule Endoscopy vs. Dedicated Small Bowel Radiography
Laine L, Sahota A, Shah A. Does Capsule Endoscopy Improve Outcomes in Obscure GI Bleeding: Randomized Controlled Trial of Capsule Endoscopy vs. Dedicated Small Bowel Radiography. Gastrointestinal Endoscopy 2009, 69: ab99. DOI: 10.1016/j.gie.2009.03.042.Peer-Reviewed Original Research
2007
Is an evidence-based approach to creating guidelines always the right one?
Fried M, Quigley E, Hunt R, Guyatt G, Anderson B, Bjorkman D, Farthing M, Fedail S, Green-Thompson R, Hampton J, Krabshuis J, Laine L, Horton R. Is an evidence-based approach to creating guidelines always the right one? Nature Reviews Gastroenterology & Hepatology 2007, 5: 60-61. PMID: 17998924, DOI: 10.1038/ncpgasthep0997.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSystematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials
McQuaid K, Laine L. Systematic review and meta-analysis of adverse events of low-dose aspirin and clopidogrel in randomized controlled trials. American Journal Of Ophthalmology 2007, 143: 194. DOI: 10.1016/j.ajo.2006.11.002.Peer-Reviewed Original Research
2006
Systematic review: the lower gastrointestinal adverse effects of non‐steroidal anti‐inflammatory drugs
LAINE L, SMITH R, MIN K, CHEN C, DUBOIS RW. Systematic review: the lower gastrointestinal adverse effects of non‐steroidal anti‐inflammatory drugs. Alimentary Pharmacology & Therapeutics 2006, 24: 751-767. PMID: 16918879, DOI: 10.1111/j.1365-2036.2006.03043.x.Peer-Reviewed Original ResearchConceptsNon-steroidal anti-inflammatory drugsLower gastrointestinal adverse effectsLower gastrointestinal injuryGastrointestinal adverse effectsAnti-inflammatory drugsGastrointestinal injuryGastrointestinal effectsClinical eventsAdverse effectsNon-selective non-steroidal anti-inflammatory drugsUpper gastrointestinal effectsHigh-quality trialsLower gastrointestinal tractEndoscopic studyGastrointestinal integrityGastrointestinal tractComputerized databaseCoxibsDisease StudyInjuryLower ratesTrialsDrugsCohortLess effectTHE MEDAL PROGRAM DESIGN: THREE RANDOMIZED TRIALS IN 34,701 PATIENTS WITH OA OR RA TO EVALUATE CARDIOVASCULAR SAFETY OF ETORICOXIB VERSUS DICLOFENAC
Bolognese J, Cannon C, Curtis S, Laine L. THE MEDAL PROGRAM DESIGN: THREE RANDOMIZED TRIALS IN 34,701 PATIENTS WITH OA OR RA TO EVALUATE CARDIOVASCULAR SAFETY OF ETORICOXIB VERSUS DICLOFENAC. JCR Journal Of Clinical Rheumatology 2006, 12: s85-s86. DOI: 10.1097/01.rhu.0000233330.39079.13.Peer-Reviewed Original Research
2003
Do NSAIDs induce esophagitis? The effect of non-specific NSAIDs and COX-2 specific inhibitors±low-dose aspirin in prospective, randomized, double-blind, placebo-controlled endoscopic trials
Laine L, Goldstein J, Fort J. Do NSAIDs induce esophagitis? The effect of non-specific NSAIDs and COX-2 specific inhibitors±low-dose aspirin in prospective, randomized, double-blind, placebo-controlled endoscopic trials. Gastroenterology 2003, 124: a511. DOI: 10.1016/s0016-5085(03)82586-6.Peer-Reviewed Original ResearchHelicobacter pylori eradication does not benefit non-ulcer dyspepsia
Laine L. Helicobacter pylori eradication does not benefit non-ulcer dyspepsia. 2003, 275-281. DOI: 10.1007/978-94-017-1763-2_28.ChaptersNon-ulcer dyspepsiaH. pylori eradication therapyPylori eradication therapyEradication therapyPylori eradicationH. pylori eradication treatmentH. pylori eradicationHelicobacter pylori eradicationPylori eradication treatmentH. pylori treatmentPylori treatmentEradication treatmentTreatment successDyspepsiaHelicobacter pyloriAetiological agentSerious methodological flawsTrialsSmall benefitPotential roleSignificant differencesMethodological flawsTherapyEradicationTreatment
2001
Morth American randomized trial of single-triple capsule (bismuth subcitrate, metronidazele, tetracycline) plus omeprazole vs. Omeprazole, amoxicillin, and clarithremycin for H. pylori eradication
Laine L, Hunt R, El-Zimaity H, Osato M, Spenard J, Pharma A. Morth American randomized trial of single-triple capsule (bismuth subcitrate, metronidazele, tetracycline) plus omeprazole vs. Omeprazole, amoxicillin, and clarithremycin for H. pylori eradication. Gastroenterology 2001, 120: a580. DOI: 10.1016/s0016-5085(08)82885-5.Peer-Reviewed Original Research
2000
H. pylori antibiotic resistance, eradication, and emergent resistance in U.S. double-blind trials of esomeprazole, clarithromycin, and amoxicillin
Laine L, Fennerty M, Suchower L, Probst P, Osato M, Levine J. H. pylori antibiotic resistance, eradication, and emergent resistance in U.S. double-blind trials of esomeprazole, clarithromycin, and amoxicillin. Gastroenterology 2000, 118: a498. DOI: 10.1016/s0016-5085(00)84113-x.Peer-Reviewed Original ResearchHow to explain outcome differences in dyspepsia studies
Fennerty M, Laine L. How to explain outcome differences in dyspepsia studies. 2000, 421-425. DOI: 10.1007/978-94-011-3927-4_44.ChaptersNon-ulcer dyspepsiaPylori infectionAdequate observation periodPlacebo-controlled trialPeptic ulcer diseaseCause of symptomsH. pylori infectionHelicobacter pylori infectionClinical treatment trialsMajor aetiological factorUlcer diseaseTreatment trialsUpper abdomenAetiological factorsEarly trial resultsStudy populationOutcome differencesEpidemiological studiesH. pyloriDyspepsiaDiscordant resultsTrial resultsObservation periodSerious methodological deficienciesTrials
1998
US double‐blind, controlled trials of omeprazole and amoxycillin for treatment of Helicobacter pylori
Laine, Johnson, Suchower, Ronca, Hwang, Neil. US double‐blind, controlled trials of omeprazole and amoxycillin for treatment of Helicobacter pylori. Alimentary Pharmacology & Therapeutics 1998, 12: 377-382. PMID: 9690729, DOI: 10.1046/j.1365-2036.1998.00303.x.Peer-Reviewed Original ResearchConceptsH. pylori eradicationDual therapyEradication ratePylori eradicationDuodenal ulcerControlled TrialsHelicobacter pylori eradication ratesOmeprazole/amoxycillinPylori eradication ratesCompletion of therapyActive duodenal ulcerH. pylori diagnosisEndoscopic biopsy testsAmoxycillin resistanceAmoxycillin therapyAdverse eventsAmoxycillinTherapyHelicobacter pyloriOmeprazolePatientsBiopsy testsProtocol analysisUlcersTrialsTwice-daily 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for H. Pylori eradication in duodenal ulcer disease: Results of 3 multicenter, double-blind, U.S. Trials
Laine L, Suchower L, Connors A, Frantz J, Neil G. Twice-daily 10-day triple therapy with omeprazole, amoxicillin, and clarithromycin for H. Pylori eradication in duodenal ulcer disease: Results of 3 multicenter, double-blind, U.S. Trials. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80787-7.Peer-Reviewed Original ResearchReduced risk of clarithromycin-resistant H. pylori with amoxicillin cotherapy: Results from 3 multicenter double-blind U.S. trials
Laine L, Suchower L, Connors A, Frantz J, Neil G. Reduced risk of clarithromycin-resistant H. pylori with amoxicillin cotherapy: Results from 3 multicenter double-blind U.S. trials. Gastroenterology 1998, 114: a193. DOI: 10.1016/s0016-5085(98)80786-5.Peer-Reviewed Original Research
1993
Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids
Yang R, Migikovsky B, Peicher J, Laine L. Randomized, prospective trial of direct current versus bipolar electrocoagulation for bleeding internal hemorrhoids. Gastrointestinal Endoscopy 1993, 39: 766-769. PMID: 8293898, DOI: 10.1016/s0016-5107(93)70261-8.Peer-Reviewed Original ResearchConceptsBipolar electrocoagulation groupElectrocoagulation groupBipolar electrocoagulationInternal hemorrhoidsTreatment groupsTreatment sessionsStandard medical therapyHaemorrhoid gradeProcedural painProspective trialMedical therapyRectal ulcerationUncontrollable bleedingHemorrhoidsRate of successPainTherapyPatientsGroupSessionsBleedingDirect current electrocoagulationUlcerationObliterationTrials
1991
Bipolar-Multipolar Electrocoagulation of Bleeding Ulcers
Laine L. Bipolar-Multipolar Electrocoagulation of Bleeding Ulcers. Gastrointestinal Endoscopy Clinics Of North America 1991, 1: 291-302. DOI: 10.1016/s1052-5157(18)30672-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements