2020
Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia
Gautam S, Stahl Y, Young GM, Howell R, Cohen AJ, Tsang DA, Martin T, Sharma L, Dela Cruz CS. Quantification of bronchoalveolar neutrophil extracellular traps and phagocytosis in murine pneumonia. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2020, 319: l661-l669. PMID: 32783617, PMCID: PMC7642899, DOI: 10.1152/ajplung.00316.2020.Peer-Reviewed Original ResearchConceptsNeutrophil extracellular trapsAcute respiratory distress syndromeChronic obstructive pulmonary diseaseNeutrophil responseExtracellular trapsDysregulation of neutrophilsObstructive pulmonary diseaseRespiratory distress syndromeNeutrophil effector functionsEx vivo assaysBronchoalveolar neutrophilsSevere asthmaDistress syndromeLung neutrophilsPulmonary diseaseMurine pneumoniaMurine modelEffector functionsNeutrophil researchMouse lungCystic fibrosisMethodologic issuesMurine researchLungArray of diseases
2019
Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii
Marion CR, Lee J, Sharma L, Park KS, Lee C, Liu W, Liu P, Feng J, Gho YS, Dela Cruz CS. Toll-Like Receptors 2 and 4 Modulate Pulmonary Inflammation and Host Factors Mediated by Outer Membrane Vesicles Derived from Acinetobacter baumannii. Infection And Immunity 2019, 87: 10.1128/iai.00243-19. PMID: 31262980, PMCID: PMC6704609, DOI: 10.1128/iai.00243-19.Peer-Reviewed Original ResearchConceptsToll-like receptorsPulmonary inflammationOuter membrane vesiclesToll-like receptor 2TLR4-deficient miceVentilator-associated pneumoniaWild-type miceSystemic inflammationNeutrophil recruitmentIntranasal introductionProinflammatory responseReceptor 2Acinetobacter baumanniiInflammationMouse lungHigh mortalityHost factorsWeight lossMicePneumoniaGram-negative bacteriumMembrane vesiclesGram-negative bacteriaTLR2ChemokinesA potential role of microvesicle-containing miR-223/142 in lung inflammation
Zhang D, Lee H, Wang X, Groot M, Sharma L, Dela Cruz CS, Jin Y. A potential role of microvesicle-containing miR-223/142 in lung inflammation. Thorax 2019, 74: 865-874. PMID: 31331947, PMCID: PMC7036165, DOI: 10.1136/thoraxjnl-2018-212994.Peer-Reviewed Original ResearchConceptsAcute lung injuryNLRP3 inflammasome activationLung inflammationInflammasome activationMacrophage-mediated inflammatory responsesBronchoalveolar lavage fluid samplesIntratracheal lipopolysaccharide (LPS) instillationUncontrolled lung inflammationInhibition of NLRP3Inflammatory lung responseLavage fluid samplesFunctions of microvesiclesLung injuryLipopolysaccharide instillationLung responseIntratracheal instillationInflammatory responseLung macrophagesMurine lungMacrophage activationMiR-223BALFInflammationLPSMiR-142
2018
Personalizing the Management of Pneumonia
Gautam S, Sharma L, Dela Cruz CS. Personalizing the Management of Pneumonia. Clinics In Chest Medicine 2018, 39: 871-900. PMID: 30390755, DOI: 10.1016/j.ccm.2018.08.008.Books