2024
Beneficial and Detrimental Effects of Cytokines during Influenza and COVID-19
Chang D, Dela Cruz C, Sharma L. Beneficial and Detrimental Effects of Cytokines during Influenza and COVID-19. Viruses 2024, 16: 308. PMID: 38400083, PMCID: PMC10892676, DOI: 10.3390/v16020308.Peer-Reviewed Original ResearchConceptsDetrimental effects of cytokinesEffects of cytokinesSignaling moleculesUnfavorable outcomeMyriad processesPathological functionsCytokine effectsInflammatory cytokinesAntiviral cytokinesCytokinesViral infectionDisease severityPathological consequencesHomeostatic functionsOrganism deathDisease
2020
The kinetics of humoral response and its relationship with the disease severity in COVID-19
Ren L, Zhang L, Chang D, Wang J, Hu Y, Chen H, Guo L, Wu C, Wang C, Wang Y, Wang Y, Wang G, Yang S, Dela Cruz CS, Sharma L, Wang L, Zhang D, Wang J. The kinetics of humoral response and its relationship with the disease severity in COVID-19. Communications Biology 2020, 3: 780. PMID: 33311543, PMCID: PMC7733479, DOI: 10.1038/s42003-020-01526-8.Peer-Reviewed Original ResearchConceptsHumoral responseDisease severityReceptor-binding domainAntibody titersSpike proteinSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2COVID-19Respiratory syndrome coronavirus 2Titers of NAbsGeometric mean titersCOVID-19 patientsSyndrome coronavirus 2Coronavirus disease 2019Disease courseMean titersCoronavirus 2Antibody responseIgG antibodiesRisk factorsIg levelsImmunoglobulin ADisease 2019Severe casesModerate infectionsDoes inflammation help during COVID-19?
Sharma L, Chang D, Dela Cruz CS. Does inflammation help during COVID-19? ERJ Open Research 2020, 6: 00557-2020. PMID: 33083436, PMCID: PMC7553107, DOI: 10.1183/23120541.00557-2020.Peer-Reviewed Original ResearchPersistent Viral Presence Determines the Clinical Course of the Disease in COVID-19
Chang D, Zhao P, Zhang D, Dong JH, Xu Z, Yang G, Li BY, Liu HX, Li BA, Qin CF, Peng XH, Wang FS, Xie LX, Chen Z, Dela Cruz CS, Sharma L, Qin EQ. Persistent Viral Presence Determines the Clinical Course of the Disease in COVID-19. The Journal Of Allergy And Clinical Immunology In Practice 2020, 8: 2585-2591.e1. PMID: 32574840, PMCID: PMC7305869, DOI: 10.1016/j.jaip.2020.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBetacoronavirusChildChild, PreschoolComorbidityCoronavirus InfectionsCOVID-19C-Reactive ProteinFemaleGlucocorticoidsHumansInfantInflammationInflammation MediatorsInterleukin-6MaleMiddle AgedPandemicsPneumonia, ViralReal-Time Polymerase Chain ReactionRespiration, ArtificialSARS-CoV-2Severity of Illness IndexYoung AdultConceptsDisease severityViral clearanceViral persistenceDisease outcomeCOVID-19Viral presenceExtensive lung involvementC-reactive proteinEffective antiviral therapyCoronavirus disease 2019Severe disease outcomesHost antiviral mechanismsInfectious viral particlesImmunomodulatory therapyInflammatory markersLung involvementRespiratory supportClinical courseAntiviral therapyIL-6Viral reactivationClinical managementInflammatory responseChest imagingDisease 2019
2019
Measurement of Chitinase Activity in Biological Samples.
Amick AK, Liu Q, Gautam S, Chupp G, Dela Cruz CS, Sharma L. Measurement of Chitinase Activity in Biological Samples. Journal Of Visualized Experiments 2019 PMID: 31498326, DOI: 10.3791/60159.Peer-Reviewed Original ResearchConceptsDisease severityType 2 inflammatory diseasesPulmonary fibrosisAllergic diseasesInflammatory diseasesHost immunityReliable biomarkersTherapeutic effectivenessGaucher diseaseHost defenseSerum samplesDiseaseChitinase-like proteinsGenetic disordersHuman subjectsPrecise roleImportant biomarkerBiomarkersSeverityImportant roleChitinase levelsAsthmaPatientsFibrosisMice