2024
Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms
Naegeli K, Niklason L. Engineered vascular grafts lend unique insight to pathophysiology of aortic aneurysms. Cell Stem Cell 2024, 31: 1099-1100. PMID: 39094540, DOI: 10.1016/j.stem.2024.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortic AneurysmBlood Vessel ProsthesisHumansInduced Pluripotent Stem CellsLoeys-Dietz SyndromeMyocytes, Smooth MuscleTissue Engineering
2016
Implantable tissue-engineered blood vessels from human induced pluripotent stem cells
Gui L, Dash BC, Luo J, Qin L, Zhao L, Yamamoto K, Hashimoto T, Wu H, Dardik A, Tellides G, Niklason LE, Qyang Y. Implantable tissue-engineered blood vessels from human induced pluripotent stem cells. Biomaterials 2016, 102: 120-129. PMID: 27336184, PMCID: PMC4939127, DOI: 10.1016/j.biomaterials.2016.06.010.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsVascular diseaseBlood vesselsAlpha-smooth muscle actinSmooth muscle myosin heavy chainActive vascular remodelingSmooth muscle cellsMuscle myosin heavy chainTissue-engineered blood vesselsStem cellsAbundant collagenous matrixPluripotent stem cellsInterposition graftAllogeneic graftsVascular remodelingΑ-SMANude ratsMuscle actinMyosin heavy chainClinical useMuscle cellsFunctional vascular smooth muscle cellsPatientsFunctional tissue-engineered blood vesselGraft
2011
Readily Available Tissue-Engineered Vascular Grafts
Dahl SL, Kypson AP, Lawson JH, Blum JL, Strader JT, Li Y, Manson RJ, Tente WE, DiBernardo L, Hensley MT, Carter R, Williams TP, Prichard HL, Dey MS, Begelman KG, Niklason LE. Readily Available Tissue-Engineered Vascular Grafts. Science Translational Medicine 2011, 3: 68ra9. PMID: 21289273, DOI: 10.1126/scitranslmed.3001426.Peer-Reviewed Original ResearchConceptsTissue-engineered vascular graftsVascular graftsMechanical propertiesSynthetic graftsAutologous tissueCoronary artery bypassCanine smooth muscle cellsPolyglycolic acid scaffoldsTissue engineeringHuman vascular graftsSmooth muscle cellsSynthetic vascular graftsArtery bypassSuch patientsArteriovenous accessArterial bypassHuman blood vesselsCardiovascular diseaseExcellent patencyBaboon modelIntimal hyperplasiaDog modelCellular materialPatientsGraft