2012
Microfluidic artificial “vessels” for dynamic mechanical stimulation of mesenchymal stem cells
Zhou J, Niklason LE. Microfluidic artificial “vessels” for dynamic mechanical stimulation of mesenchymal stem cells. Integrative Biology 2012, 4: 1487-1497. PMID: 23114826, PMCID: PMC3628532, DOI: 10.1039/c2ib00171c.Peer-Reviewed Original ResearchMeSH KeywordsBeta CateninBiomechanical PhenomenaBlood VesselsCell DifferentiationCells, CulturedEquipment DesignHumansMesenchymal Stem CellsMicrofluidic Analytical TechniquesSignal TransductionSmad ProteinsStress, MechanicalSystems BiologyTissue EngineeringTransforming Growth Factor betaWnt Signaling PathwayConceptsVascular tissue engineeringMicrofluidic channelTissue engineeringDynamic mechanical stimulationHydrodynamic actuationDeformable membraneDevice fatigueStem cell mechanobiologyCyclic strainComplex mechanical stimulationMechanical environmentCell mechanobiologyMesenchymal stem cellsPerformance degradationCyclic stimulationStem cellsBiomechanical conditionsCyclic circumferential strainMicrochip platformSignal transduction cascadeMechanical stimulationVascular cell lineagesVersatile platformEngineeringCanonical Wnt/β-catenin
2011
Decellularized tissue-engineered blood vessel as an arterial conduit
Quint C, Kondo Y, Manson RJ, Lawson JH, Dardik A, Niklason LE. Decellularized tissue-engineered blood vessel as an arterial conduit. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 9214-9219. PMID: 21571635, PMCID: PMC3107282, DOI: 10.1073/pnas.1019506108.Peer-Reviewed Original ResearchConceptsTissue-engineered vesselsBiomimetic perfusion systemArterial tissue engineeringTissue-engineered blood vesselsTissue engineering techniquesEndothelial progenitor cellsTissue engineeringRobust extracellular matrixVein graftsBiological vascular graftPorcine carotid arteriesVascular graftsTissue regenerationIntimal hyperplasiaAutologous endothelial progenitor cellsGraft wallProgenitor cellsControl vein graftsSmooth muscle cellsGraft lumenGraft occlusionArterial conduitsImproved patencyCarotid arteryPorcine smooth muscle cells