2022
Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm
O'Neill KE, Maher JY, Laronda MM, Duncan FE, LeDuc RD, Lujan ME, Oktay KH, Pouch AM, Segars JH, Tsui EL, Zelinski MB, Halvorson LM, Gomez-Lobo V. Anatomic nomenclature and 3-dimensional regional model of the human ovary: call for a new paradigm. American Journal Of Obstetrics And Gynecology 2022, 228: 270-275.e4. PMID: 36191605, PMCID: PMC9974561, DOI: 10.1016/j.ajog.2022.09.040.Peer-Reviewed Original ResearchLaparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia
Vash-Margita A, Szymanska-Vandendriessche K, Gunther K, Rodriguez-Buritica DF, Christison-Lagay E, Saluja S, Oktay KH. Laparoscopic ovarian tissue harvesting for cryopreservation from a child with galactosemia. Fertility And Sterility 2022, 118: 982-984. PMID: 36154768, DOI: 10.1016/j.fertnstert.2022.08.005.Peer-Reviewed Original ResearchConceptsAntimüllerian hormone levelsOvarian tissue cryopreservationFertility preservationMonths of ageHormone levelsPrimordial folliclesAMH levelsMIU/Right ovaryTissue cryopreservationOvarian tissueReproductive endocrinologyOvarian tissue harvestingLower AMH levelsUneventful postoperative courseGood metabolic controlPelvic magnetic resonanceSubsequent histological examinationSmall antral folliclesPrimary ovarian insufficiencyTissue harvestingEffect of cauterizationYoung female childMagnetic resonance imaging (MRI) examsRare genetic disorderImpact of chemotherapy on the ovarian reserve: Are all primordial follicles created equal?
Oktay K, Marin L, Titus S. Impact of chemotherapy on the ovarian reserve: Are all primordial follicles created equal? Fertility And Sterility 2022, 117: 396-398. PMID: 34998576, DOI: 10.1016/j.fertnstert.2021.12.007.Peer-Reviewed Original Research
2021
Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data
Oktay K, Marin L, Bedoschi G, Pacheco F, Sugishita Y, Kawahara T, Taylan E, Acosta C, Bang H. Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data. Fertility And Sterility 2021, 117: 181-192. PMID: 34801235, PMCID: PMC8863399, DOI: 10.1016/j.fertnstert.2021.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesCryopreservationExtracellular MatrixFemaleFertility PreservationHumansMeta-Analysis as TopicNeovascularization, PhysiologicOvaryPregnancyPregnancy RateRetrospective StudiesRobotic Surgical ProceduresTissue Culture TechniquesTissue ScaffoldsTransplantation, AutologousYoung AdultConceptsGraft longevityCase seriesOvarian functionLow-dose aspirinOvarian tissue transplantationOvarian cortical piecesLower embryo qualityOocytes/embryosNeonatal outcomesTransdermal estrogenChemotherapy exposureOvarian transplantationCortical piecesMeta-analytic dataLower abdomenHealthy childrenLive birthsMAIN OUTCOMEGraft vascularizationExtracellular matrix scaffoldsOvarian tissueAneuploidy rateFunction returnsEmbryo qualityMeta-analytic updateComparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation
Sugishita Y, Taylan E, Kawahara T, Shahmurzada B, Suzuki N, Oktay K. Comparison of open and a novel closed vitrification system with slow freezing for human ovarian tissue cryopreservation. Journal Of Assisted Reproduction And Genetics 2021, 38: 2723-2733. PMID: 34398400, PMCID: PMC8581089, DOI: 10.1007/s10815-021-02297-9.Peer-Reviewed Original ResearchConceptsFollicle survivalCortical piecesPrimary folliclesHuman ovarian tissue cryopreservationOvarian tissue cryopreservationCell death pathway activationOvarian cortical piecesPrimordial follicle survivalPrimordial follicle densityHuman ovarian tissueClosed vitrification systemTissue cryopreservationDNA damageOvarian tissueHistological analysisPathway activationApoptosis rateDevice groupSlow freezingDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantationIndividual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation
Titus S, Szymanska K, Musul B, Turan V, Taylan E, Garcia- Milian R, Mehta S, Oktay K. Individual-oocyte transcriptomic analysis shows that genotoxic chemotherapy depletes human primordial follicle reserve in vivo by triggering proapoptotic pathways without growth activation. Scientific Reports 2021, 11: 407. PMID: 33431979, PMCID: PMC7801500, DOI: 10.1038/s41598-020-79643-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisCyclophosphamideDNA DamageFemaleGene Expression ProfilingHeterograftsHumansMiceMice, Inbred NODMice, SCIDOocytesOogenesisOvarian FollicleOvarian ReserveOvarySignal TransductionSingle-Cell AnalysisTranscriptomeYoung AdultConceptsPrimordial follicle oocytesFollicle lossGrowth activationHuman ovarian xenograft modelPI3K/PTEN/AktFollicle oocytesDNA damagePI3K/PTEN/Akt pathwayOvarian reserve depletionPrimordial follicle reservePTEN/AKT pathwayIngenuity Pathway AnalysisOvarian xenograft modelPTEN/AKTSevere DNA damageExpression of AktGonadotoxic chemotherapyAnti-apoptotic Bcl2Early menopauseFollicle reserveTranscriptomic analysisCyclophosphamide injectionHuman ovaryPhosphorylation statusRNA sequencing
2020
Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging
Szymanska K, Tan X, Oktay K. Unraveling the mechanisms of chemotherapy-induced damage to human primordial follicle reserve: road to developing therapeutics for fertility preservation and reversing ovarian aging. Molecular Human Reproduction 2020, 26: 553-566. PMID: 32514568, PMCID: PMC7411370, DOI: 10.1093/molehr/gaaa043.Peer-Reviewed Original ResearchConceptsPrimordial follicle reserveChemotherapy-induced damageFollicle reserveOvarian reserveChemotherapy-induced lossOvarian reserve depletionApoptotic deathPrimordial follicle oocytesFertility preservationAcute reductionOvarian agingHuman ovaryFollicle activationPrimordial folliclesAcute exposureStromal damageTranslational evidenceChemotherapeutic agentsApoptotic lossFollicle oocytesDNA double-strand breaksDNA DSBsCurrent literatureDeathActivation
2019
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging
Turan V, Oktay K. BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging. Human Reproduction Update 2019, 26: 43-57. PMID: 31822904, PMCID: PMC6935693, DOI: 10.1093/humupd/dmz043.Peer-Reviewed Original ResearchAdvances in fertility-preservation surgery: navigating new frontiers
Christianson M, Oktay K. Advances in fertility-preservation surgery: navigating new frontiers. Fertility And Sterility 2019, 112: 438-445. PMID: 31446903, DOI: 10.1016/j.fertnstert.2019.06.029.Peer-Reviewed Original ResearchConceptsFertility preservation surgeryFertility preservationSurgical optionsVital reproductive organFertility-preserving surgeryUterine fixationRadical trachelectomyGynecologic malignanciesFemale patientsFirst transplantationCancer patientsReproductive organsFuture fertilityReproductive surgeryMedical conditionsTransposition procedureSelect cancersSurgerySurgical creativityTissue 20PatientsMajor advancesOrgansTrachelectomyTransplantation
2012
Ovarian cryopreservation.
Jeong K, Aslan E, Ozkaya E, Sonmezer M, Oktay K. Ovarian cryopreservation. Minerva Medica 2012, 103: 37-46. PMID: 22278067.Peer-Reviewed Original ResearchConceptsFertility preservationOvarian tissueNon-malignant diseasesFuture autotransplantationOvarian cryopreservationOvarian failurePrepubertal girlsReproductive endocrinologistsMalignant cellsTeam approachWhole ovariesHeterotopic locationNew promising strategyAutotransplantationSignificant delayDiseaseTissue piecesTissuePromising strategySlow freezingChemotherapyLaparoscopyPatientsEndocrinologistsOncologists
2009
Fertility Preservation for Breast Cancer Patients
Oktem O, Oktay K. Fertility Preservation for Breast Cancer Patients. Seminars In Reproductive Medicine 2009, 27: 486-492. PMID: 19806518, DOI: 10.1055/s-0029-1241059.Peer-Reviewed Original ResearchConceptsBreast cancer patientsOvarian stimulation protocolsCancer patientsBreast cancerFertility preservationCancer survivorsStimulation protocolConventional ovarian stimulation protocolsRise of estrogenOvarian tissue freezingBreast cancer survivorsPreservation of fertilityEndogenous estrogen levelsFertility preservation strategiesAromatase inhibitor letrozolePremature ovarian failureNew cancer casesAdjuvant chemotherapyOvarian stimulationFertilization cyclesEstrogen levelsOvarian failureOocyte freezingReproductive ageCommon neoplasmStem cells and reproductive medicine.
Oktem O, Oktay K. Stem cells and reproductive medicine. Minerva Obstetrics And Gynecology 2009, 61: 247-52. PMID: 19745792.Peer-Reviewed Original Research
2005
Oocyte and Ovarian Tissue Cryopreservation: Indications, Techniques, and Applications
Shamonki M, Oktay K. Oocyte and Ovarian Tissue Cryopreservation: Indications, Techniques, and Applications. Seminars In Reproductive Medicine 2005, 23: 266-276. PMID: 16059833, DOI: 10.1055/s-2005-872455.Peer-Reviewed Original Research
2002
The potential of ovarian tissue transplant to preserve fertility
Buyuk E, Oktay K. The potential of ovarian tissue transplant to preserve fertility. Expert Opinion On Biological Therapy 2002, 2: 361-370. PMID: 11955275, DOI: 10.1517/14712598.2.4.361.Peer-Reviewed Original ResearchConceptsClinical studiesOvarian tissue transplantsSafety of pregnancyFuture clinical trialsPremature ovarian failureOvarian follicle developmentOvarian graftsOvarian cryopreservationOvarian transplantationOvarian functionCancer patientsOvarian failureClinical trialsAnimal studiesTissue transplantsOvarian tissueFurther basic researchHormone productionFollicle developmentRevascularisation processPregnancyPatientsTransplantationWomenSafetyPreliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips
Oktay K, Yih M. Preliminary Experience with Orthotopic and Heterotopic Transplantation of Ovarian Cortical Strips. Seminars In Reproductive Medicine 2002, 20: 063-074. PMID: 11941536, DOI: 10.1055/s-2002-23520.Peer-Reviewed Original ResearchConceptsOvarian cortical stripsOvarian transplantationOvarian tissueCortical stripsHeterotopic transplantationAutologous ovarian transplantationFrozen ovarian tissueHeterotopic techniqueNew York surgeonPatient selectionOvarian functionSurgical techniqueTransplantationTransplanted tissuePreliminary experienceExperimental modelOperating roomCancer cellsClinical applicationTissueSafety measuresOrthotopicCliniciansSurgeonsTrounson
2001
Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients
Oktay K. Ovarian tissue cryopreservation and transplantation: preliminary findings and implications for cancer patients. Human Reproduction Update 2001, 7: 526-534. PMID: 11727860, DOI: 10.1093/humupd/7.6.526.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationYoung womenFrozen-banked ovarian tissueBone marrow transplantationCancers of childrenAntral follicle developmentAggressive chemotherapyComplete remissionCancer treatment modalitiesMarrow transplantationBenign causesCancer patientsTreatment modalitiesTransplantation trialsFresh graftsXenograft studiesRodent studiesOocyte cryopreservationOvarian tissuePatientsFollicle developmentTransplantationCancer treatmentWomenRecent progress in oocyte and ovarian tissue cryopreservation and transplantation
Oktay K, Kan M, Rosenwaks Z. Recent progress in oocyte and ovarian tissue cryopreservation and transplantation. Current Opinion In Obstetrics & Gynecology 2001, 13: 263-268. PMID: 11396648, DOI: 10.1097/00001703-200106000-00003.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationOocyte freezingTissue cryopreservationOocyte cryopreservationOvarian tissueOvarian stimulation cyclesGroup of patientsNumber of pregnanciesInstitutional review boardOvarian transplantationAge-related declineOvarian functionStimulation cyclesReproductive surgeryContext of cancerCryopreserved oocytesReproductive functionEmbryo freezingTransplantationReview boardFirst caseInadequate timeSignificant scientific advancesWomenOocytesA technique for laparoscopic transplantation of frozen-banked ovarian tissue
Oktay K, Aydin B, Karlikaya G. A technique for laparoscopic transplantation of frozen-banked ovarian tissue. Fertility And Sterility 2001, 75: 1212-1216. PMID: 11384651, DOI: 10.1016/s0015-0282(01)01776-9.Peer-Reviewed Original ResearchConceptsFrozen-banked ovarian tissueLaparoscopic transplantationOvarian tissueAcademic medical centerSlow-freezing techniqueMenopausal gonadotropinOvarian stimulationSpontaneous mensesOvarian fossaPelvic peritoneumOvarian functionLaparoscopic techniqueOvarian cortexMedical CenterMAIN OUTCOMEMicrosurgical reconstructionProgesterone productionBlood flowFollicle developmentTransplantationPatientsTissueMensesGonadotropinTransplant
2000
Ovarian cryopreservation and transplantation: basic aspects
Oktay K, Karlikaya G, Aydin B. Ovarian cryopreservation and transplantation: basic aspects. Molecular And Cellular Endocrinology 2000, 169: 105-108. PMID: 11155939, DOI: 10.1016/s0303-7207(00)00361-0.Peer-Reviewed Original Research