2023
Effect of PEEP Setting With Minimal Driving Pressure on the Distribution of Voxel-level Lung Strain and Aeration Measured With Dynamic Computed Tomography (CT) in Large Animal Normal and Injured Lungs
Zeng C, Lagier D, Zhu M, Rashid A, Winkler T, Grogg K, Gerard S, Kaczka D, Reinhardt J, Vidal Melo M. Effect of PEEP Setting With Minimal Driving Pressure on the Distribution of Voxel-level Lung Strain and Aeration Measured With Dynamic Computed Tomography (CT) in Large Animal Normal and Injured Lungs. 2023, a6061-a6061. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6061.Peer-Reviewed Original Research
2018
Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury
Motta-Ribeiro G, Hashimoto S, Winkler T, Baron R, Grogg K, Paula L, Santos A, Zeng C, Hibbert K, Harris R, Bajwa E, Vidal Melo M. Deterioration of Regional Lung Strain and Inflammation during Early Lung Injury. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 891-902. PMID: 29787304, PMCID: PMC6173064, DOI: 10.1164/rccm.201710-2038oc.Peer-Reviewed Original ResearchMeSH KeywordsAcute Lung InjuryAnalysis of VarianceAnimalsBiopsy, NeedleBlood Gas AnalysisDisease Models, AnimalEndotoxemiaEndotoxinsFemaleFluorodeoxyglucose F18HumansImmunohistochemistryInfusions, IntravenousLinear ModelsMultivariate AnalysisPositron-Emission TomographyPulmonary AtelectasisRandom AllocationRespiration, ArtificialRespiratory Distress SyndromeRespiratory Function TestsRisk FactorsSheepTidal VolumeTime FactorsTomography, X-Ray ComputedConceptsLung injurySupine lungConsistent with clinical practiceBlood volumeF-FDG phosphorylation rateLocal neutrophilic inflammationAssociated with increased inflammationF-FDG uptakeEarly mechanical ventilationClinical practiceEarly lung injuryPositive end-expiratory pressureLung strainEnd-expiratory pressurePositron emission tomographyF-FDGUninjured lungsImaging findingsRegional inflammationNeutrophilic inflammationSystemic endotoxemiaProne positionComputed tomographyVentilated patientsIntravenous endotoxin