2024
From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Knoedler L, Huelsboemer L, Hollmann K, Alfertshofer M, Herfeld K, Hosseini H, Boroumand S, Stoegner V, Safi A, Perl M, Knoedler S, Pomahac B, Kauke-Navarro M. From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases. Frontiers In Immunology 2024, 15: 1276306. PMID: 38715609, PMCID: PMC11074450, DOI: 10.3389/fimmu.2024.1276306.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalHumansImmune Checkpoint InhibitorsNeoplasmsPlastic Surgery ProceduresConceptsImmune checkpoint inhibitorsHead and neck cancerBreast cancerMonoclonal antibodiesCheckpoint inhibitorsSkin cancerReconstructive surgeryNon-surgical treatment strategiesProlonged progression-free survivalSuboptimal treatment plansProgression-free survivalNon-surgical therapySurgical tumor resectionImpaired patient outcomeStandardized treatment algorithmSurgical therapy planningAnti-cancer strategyUnresectable tumorsConventional chemotherapyRemission rateTumor resectionCurative therapyTargeted therapyNeck cancerOncology cases
2023
Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma
Noel O, Dumbrava M, Daoud D, Kammien A, Kauke-Navarro M, Pomahac B, Colen D. Vascularized Composite Allograft Versus Prosthetic for Reconstruction After Facial and Hand Trauma. Annals Of Plastic Surgery 2023, 92: 100-105. PMID: 37962243, DOI: 10.1097/sap.0000000000003731.Peer-Reviewed Original ResearchMeSH KeywordsComposite Tissue AllograftsFacial InjuriesHumansPlastic Surgery ProceduresUpper ExtremityVascularized Composite AllotransplantationConceptsHand traumaHand/upper extremityLong-term outcomesUpper extremity traumaDifferent reconstructive optionsUse of prosthesesExtremity traumaBenefit profileUpper extremityReconstructive optionsComposite allotransplantationFace traumaHand reconstructionTraumaClinical realityPrimary optionProsthesisPatientsVCAArtificial intelligence-enabled simulation of gluteal augmentation: A helpful tool in preoperative outcome simulation?
Knoedler L, Odenthal J, Prantl L, Oezdemir B, Kehrer A, Kauke-Navarro M, Matar D, Obed D, Panayi A, Broer P, Chartier C, Knoedler S. Artificial intelligence-enabled simulation of gluteal augmentation: A helpful tool in preoperative outcome simulation? Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 80: 94-101. PMID: 37001299, DOI: 10.1016/j.bjps.2023.01.039.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsArtificial IntelligenceButtocksHumansPlastic Surgery ProceduresSurgical Flaps
2022
How to attract our future? - Perception of plastic surgery among medical students
Odenthal J, Knoedler L, Oezdemir B, Prantl L, Machens H, Broer P, von Isenburg S, Rieger U, Kauke M, Panayi A, Knoedler S. How to attract our future? - Perception of plastic surgery among medical students. Journal Of Plastic Reconstructive & Aesthetic Surgery 2022, 80: 4-12. PMID: 36931006, DOI: 10.1016/j.bjps.2022.08.059.Peer-Reviewed Original ResearchFactor Analysis, StatisticalFemaleHumansPerceptionPlastic Surgery ProceduresStudents, MedicalSurgery, Plastic
2021
The Impact of Metabolic Syndrome on Microvascular Head and Neck Reconstruction: An ACS-NSQIP data analysis
Panayi AC, Haug V, Kauke-Navarro M, Diehm YF, Pomahac B. The Impact of Metabolic Syndrome on Microvascular Head and Neck Reconstruction: An ACS-NSQIP data analysis. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 1360-1371. PMID: 34955390, DOI: 10.1016/j.bjps.2021.11.074.Peer-Reviewed Original ResearchMeSH KeywordsData AnalysisFree Tissue FlapsHead and Neck NeoplasmsHumansMetabolic SyndromePlastic Surgery ProceduresPostoperative ComplicationsRetrospective StudiesSepsisShock, SepticConceptsSuperficial incisional infectionSeptic shockMedical complicationsNeck microvascular reconstructionMetS patientsMicrovascular reconstructionIncisional infectionPostoperative outcomesMetS groupMetabolic syndromeSurgical outcomesHigh rateOrgan space infectionPostoperative medical complicationsOccurrence of sepsisAverage operative timeImpact of MetSMicrovascular flap reconstructionPoor surgical outcomesSkilled care facilitySite of surgeryFree skin flapsType of flapTerms of demographicsHospital stayThe modified 5-item frailty index is a predictor of perioperative risk in head and neck microvascular reconstruction: An analysis of 3795 cases
Panayi AC, Haug V, Kauke-Navarro M, Foroutanjazi S, Diehm YF, Pomahac B. The modified 5-item frailty index is a predictor of perioperative risk in head and neck microvascular reconstruction: An analysis of 3795 cases. American Journal Of Otolaryngology 2021, 42: 103121. PMID: 34171698, DOI: 10.1016/j.amjoto.2021.103121.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnastomosis, SurgicalDiabetes MellitusFemaleForecastingFrailtyHeadHeart FailureHumansHypertensionLength of StayMaleMicrovesselsMiddle AgedNeckOperative TimePlastic Surgery ProceduresPostoperative ComplicationsPulmonary Disease, Chronic ObstructiveSeverity of Illness IndexSurgical FlapsTreatment OutcomeConceptsNeck microvascular reconstructionMFI-5Microvascular reconstructionMFI scoreSubgroup analysisNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseChronic obstructive pulmonary diseaseFrailty index-5Non-home dischargeImprovement Program databaseAverage operative timeCongestive heart failureObstructive pulmonary diseasePost-operative outcomesPre-operative identificationPost-operative supportTerms of demographicsHospital stayPerioperative riskUnplanned readmissionHome dischargePostoperative outcomesYounger patientsFrailty index
2020
Combined (endo-)vascular intervention and microsurgical lower extremity free flap reconstruction—A propensity score matching analysis in 5386 ACS-NSQIP patients
Haug V, Kadakia N, Panayi AC, Kauke M, Hundeshagen G, Diehm Y, Fischer S, Hirche C, Kneser U, Pomahac B. Combined (endo-)vascular intervention and microsurgical lower extremity free flap reconstruction—A propensity score matching analysis in 5386 ACS-NSQIP patients. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 1031-1040. PMID: 33436337, DOI: 10.1016/j.bjps.2020.10.045.Peer-Reviewed Original ResearchConceptsFree flap reconstructionLower extremity free flap reconstructionFlap reconstructionLimb amputationNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseAnesthesiology physical status classificationQuality Improvement Program databaseMicrosurgical free flap reconstructionPropensity scoreACS-NSQIP patientsLower limb perfusionPreoperative steroid usePropensity-matched cohortImprovement Program databaseModifiable risk factorsPeripheral artery diseasePhysical status classificationCareful preoperative assessmentSick patient populationLower limb amputationLower extremity salvageLower limb reconstructionFree flap transferFree tissue transfer
2019
The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation
Safi AF, Schröder K, Kauke M, Safi S, Zöller JE, Zinser M. The Importance of Serological Procalcitonin Levels After Autologous Microsurgical Transplantation. Journal Of Craniofacial Surgery 2019, Publish Ahead of Print: &na;. PMID: 30817542, DOI: 10.1097/scs.0000000000005431.Peer-Reviewed Original ResearchMeSH KeywordsHumansMicrosurgeryPlastic Surgery ProceduresPostoperative ComplicationsProcalcitoninRetrospective StudiesTransplantation, AutologousVascular GraftingConceptsSoft tissue defectsPCT levelsProcalcitonin levelsSystemic inflammationMicrosurgical interventionTissue defectsPCT cutoff levelPerioperative systemic inflammationHigh mortality rateMicrovascular transplantsMicrovascular transplantationSevere complicationsSevere morbidityRetrospective studySurgical interventionTransplant lossMicrosurgical transplantationTreatment strategiesInclusion criteriaCutoff levelMortality ratePatientsReconstructive surgeonPathological levelsDetectable increase
2018
Clinical Evaluation of Standardized Fronto-Orbital Advancement for Correction of Isolated Trigonocephaly
Safi AF, Kreppel M, Grandoch A, Kauke M, Nickenig HJ, Zöller J. Clinical Evaluation of Standardized Fronto-Orbital Advancement for Correction of Isolated Trigonocephaly. Journal Of Craniofacial Surgery 2018, 29: 72-75. PMID: 29040150, DOI: 10.1097/scs.0000000000004058.Peer-Reviewed Original ResearchMeSH KeywordsCraniosynostosesFemaleFrontal BoneHumansInfantMaleOperative TimeOrbitPlastic Surgery ProceduresPostoperative ComplicationsRetrospective StudiesTreatment OutcomeConceptsFronto-orbital advancementClinical outcomesPatient cohortWhitaker scoreLow complication rateMean operation timeTreatment-naive childrenPostoperative complicationsComplication rateMajor complicationsCorrective surgeryDural tearRetrospective studySubdural hematomaMean ageClinical evaluationInclusion criteriaFronto-orbital advancement proceduresClinical successFrontoorbital advancementPatientsMorphological outcomesTrigonocephalyOperation timeAdvancement procedureRigid External Distractor-Aided Advancement After Simultaneously Performed LeFort-III Osteotomy and Fronto-Orbital Advancement
Safi AF, Kreppel M, Kauke M, Grandoch A, Nickenig HJ, Zöller J. Rigid External Distractor-Aided Advancement After Simultaneously Performed LeFort-III Osteotomy and Fronto-Orbital Advancement. Journal Of Craniofacial Surgery 2018, 29: 170-174. PMID: 29068973, DOI: 10.1097/scs.0000000000004061.Peer-Reviewed Original ResearchConceptsFronto-orbital advancementLeFort III osteotomyStandardized treatment protocolTreatment protocolEsthetic outcomeDistraction osteogenesisPerioperative hemoglobin concentrationRigid external distractor deviceConventional surgical techniquesDuration of operationLow infection rateLeft temporal siteRigid external distractorPostoperative complicationsCorrective surgeryRetrospective studySkeletal advancementSurgical outcomesFunctional outcomeFunctional resultsSurgical methodsSurgical techniquePatientsHemoglobin concentrationInfection rate