2018
Does volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma?
Safi AF, Kauke M, Jung H, Timmer M, Borggrefe J, Persigehl T, Nickenig HJ, Zinser M, Maintz D, Kreppel M, Zöller J. Does volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma? Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1013-1018. PMID: 29709330, DOI: 10.1016/j.jcms.2018.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersCarcinoma, Squamous CellChemoradiotherapyFemaleHumansLymph NodesLymphatic MetastasisMaleMicrosurgeryMiddle AgedMouth NeoplasmsMultivariate AnalysisNeckNeck DissectionNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesRisk FactorsTomography, X-Ray ComputedConceptsOral squamous cell carcinomaLymph node volumeSquamous cell carcinomaLocoregional recurrenceN classificationCell carcinomaNode volumeInclusion criteriaComputed tomographyTreatment-naive oral squamous cell carcinomaIpsilateral lymph node metastasisBetter risk stratification toolsComprehensive neck dissectionPathological N classificationCervical lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolLymph node metastasisPreoperative computed tomographyVolumetric measurementsT4b classificationUnresectable diseaseLocoregional failureNeoadjuvant chemoradiotherapyThe importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller J, Kreppel M. The importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1007-1012. PMID: 29709331, DOI: 10.1016/j.jcms.2018.03.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapyFemaleHumansKaplan-Meier EstimateLymph Node ExcisionLymph NodesLymphatic MetastasisMaleMandibleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeck DissectionNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesRisk AssessmentConceptsOral squamous cell carcinomaSquamous cell carcinomaMandibular infiltrationLocoregional recurrenceCell carcinomaLymph nodesExclusion criteriaTreatment-naive oral squamous cell carcinomaImportance of lymphPathologic N classificationLymph node ratioPositive lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolAssessment of prognosisConventional nodalT4b classificationUnresectable diseaseNeoadjuvant chemoradiotherapyPerioperative deathsSynchronous malignanciesChart reviewResection marginsClinicopathological characteristics
2017
Clinicopathological parameters affecting nodal yields in patients with oral squamous cell carcinoma receiving selective neck dissection
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Drebber U, Zöller J, Kreppel M. Clinicopathological parameters affecting nodal yields in patients with oral squamous cell carcinoma receiving selective neck dissection. Journal Of Cranio-Maxillofacial Surgery 2017, 45: 2092-2096. PMID: 29033003, DOI: 10.1016/j.jcms.2017.08.020.Peer-Reviewed Original ResearchConceptsOral squamous cell carcinomaSquamous cell carcinomaNodal yieldSelective neck dissectionCell carcinomaNeck dissectionLymph nodesLocoregional recurrenceT classificationTreatment-naive oral squamous cell carcinomaCervical lymph node statusMean nodal yieldBilateral neck dissectionCervical lymph nodesLymph node statusRetrospective chart reviewMinimum lymphT4b classificationPerioperative deathsUnresectable diseaseNeoadjuvant chemoradiotherapySynchronous malignanciesChart reviewClinicopathological factorsPerineural invasionAnalysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma – Retrospective analysis of 517 patients
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller JE, Kreppel M. Analysis of clinicopathological risk factors for locoregional recurrence of oral squamous cell carcinoma – Retrospective analysis of 517 patients. Journal Of Cranio-Maxillofacial Surgery 2017, 45: 1749-1753. PMID: 28823597, DOI: 10.1016/j.jcms.2017.07.012.Peer-Reviewed Original ResearchConceptsCervical lymph nodesClinicopathological risk factorsIndependent risk factorSignificant risk factorsLocoregional recurrenceRisk factorsLymph nodesMultivariate analysisExtracapsular spreadHistological gradingTreatment-naive oral squamous cell carcinomaPossible significant risk factorPositive cervical lymph nodesOral squamous cell carcinomaIndividualized therapy managementPositive lymph nodesNegative resection marginsOverall survival rateSquamous cell carcinomaBinary logistic regression analysisLogistic regression analysisImprovement of therapyMaxillofacial plastic surgeryClinicopathological factorsResection marginsThe importance of log odds of positive lymph nodes for locoregional recurrence in oral squamous cell carcinoma
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Drebber U, Zöller J, Kreppel M. The importance of log odds of positive lymph nodes for locoregional recurrence in oral squamous cell carcinoma. Oral Oncology 2017, 72: 48-55. PMID: 28797461, DOI: 10.1016/j.oraloncology.2017.07.005.Peer-Reviewed Original ResearchConceptsPositive lymph nodesOral squamous cell carcinomaSquamous cell carcinomaLymph node ratioLocoregional recurrenceLymph nodesCell carcinomaTreatment-naive oral squamous cell carcinomaNode ratioLog oddsIndependent indicatorPathologic N classificationPathologic T classificationRetrospective chart reviewMultiple cancer sitesConventional nodalT4b classificationUnresectable diseaseExtracapsular spreadNeoadjuvant chemoradiotherapyPerioperative deathsSynchronous malignanciesChart reviewNodal yieldN classification