2025
From Novel Facial Measurements to Facial Implantology: A Systematic Review
Baecher H, Scheiflinger A, Remy K, Straub N, Maheta B, Sherwani K, Deniz C, Knoedler S, Safi A, Kauke-Navarro M, Heiland M, Knoedler L. From Novel Facial Measurements to Facial Implantology: A Systematic Review. JPRAS Open 2025, 43: 1-17. DOI: 10.1016/j.jpra.2024.10.005.Peer-Reviewed Original ResearchFacial implantsFacial measurementsOptimal implant planningSurgical site infectionStandard facial measurementsImplant planningSite infectionAesthetic outcomesBone augmentationPotential complicationsWeb of ScienceNasal regionPatient satisfactionPorous polyethyleneComprehensive searchSystematic reviewComplicationsPatientsImplantationOutcomesCentral databaseFacial analysisReviewImplantologyMandibular
2024
The role of C4d and donor specific antibodies in face and hand transplantation—a systematic review
Huelsboemer L, Moscarelli J, Dony A, Boroumand S, Kochen A, Knoedler L, Yu C, Hauc S, Stögner V, Formica R, Lian C, Murphy G, Pomahac B, Kauke-Navarro M. The role of C4d and donor specific antibodies in face and hand transplantation—a systematic review. Frontiers In Transplantation 2024, 3: 1442006. PMID: 39291278, PMCID: PMC11405992, DOI: 10.3389/frtra.2024.1442006.Peer-Reviewed Original ResearchDonor-specific antibodiesSerum donor-specific antibodiesAntibody-mediated rejectionHigher rejection gradesVascularized composite allotransplantationC4d depositionRejection gradeCellular rejectionRejection episodesSpecific antibodiesDonor-specific antibody statusManagement of antibody-mediated rejectionFace transplantationAcute cellular rejectionAcute rejection episodesAssociated with high gradeTime of biopsyAntibody mediated rejectionFisher's exact testMann-Whitney U testSystematic review of electronic databasesMechanisms of rejectionSystematic reviewReview of electronic databasesC4d stainingAdvancements in facial implantology: a review of hydroxyapatite applications and outcomes
Kauke-Navarro M, Knoedler L, Knoedler S, Safi A. Advancements in facial implantology: a review of hydroxyapatite applications and outcomes. Frontiers In Surgery 2024, 11: 1409733. PMID: 39092153, PMCID: PMC11291363, DOI: 10.3389/fsurg.2024.1409733.Peer-Reviewed Original ResearchFacial skeletal reconstructionLong-term safetySkeletal reconstructionFacial balanceTumor resectionCraniofacial surgeryAesthetic resultsFacial implantsReconstructive surgeryWeb of Science databasesInclusion criteriaPatient outcomesPatient satisfactionPatientsImplant integrationSystematic reviewSurgeryFacial reconstructionHAP implantsOutcomesGoogle ScholarScience databasesEfficacyHydroxyapatite applicationImplantationQuality of life and satisfaction after breast augmentation: A systematic review and meta-analysis of Breast-Q patient-reported outcomes
Knoedler S, Knoedler L, Kauke-Navarro M, Alfertshofer M, Obed D, Broer N, Kim B, Könneker S, Panayi A, Hundeshagen G, Kneser U, Pomahac B, Haug V. Quality of life and satisfaction after breast augmentation: A systematic review and meta-analysis of Breast-Q patient-reported outcomes. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 95: 300-318. PMID: 38945110, DOI: 10.1016/j.bjps.2024.06.016.Peer-Reviewed Original ResearchPhysical well-beingSexual well-beingWell-beingPatient-reported physical well-beingPatient reportsMeta-analysisPsychosocial well-beingPatient-reported outcomesPatient-reported quality of lifeBreast augmentationQuality of lifeHigher QoLPairwise meta-analysisA systematic reviewPatients' QoLPatient satisfactionSystematic reviewEligibility criteriaPRISMA guidelinesPostoperative follow-up timeQoLQuantitative synthesisFollow-up timeSubgroup analysisSatisfactionImmunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes
Huelsboemer L, Boroumand S, Kochen A, Dony A, Moscarelli J, Hauc S, Stögner V, Formica R, Pomahac B, Kauke-Navarro M. Immunosuppressive strategies in face and hand transplantation: a comprehensive systematic review of current therapy regimens and outcomes. Frontiers In Transplantation 2024, 3: 1366243. PMID: 38993787, PMCID: PMC11235358, DOI: 10.3389/frtra.2024.1366243.Peer-Reviewed Original ResearchCMV infectionImmunosuppressive regimensImmunosuppressive strategiesTransplant recipientsIncidence of rejection episodesClinical CMV infectionTriple maintenance therapyIncidence of rejectionEpisodes of rejectionIndividualized immunosuppressive regimensEffective immunosuppressive therapySystematic reviewFace transplant patientsHand transplant recipientsHand transplantationFacial graftImmunosuppressive therapyMaintenance therapyRejection episodesFacial mucosaGraft lossGraft rejectionTherapy regimensTransplant patientsRenal failureSurface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality?
Kauke-Navarro M, Knoedler L, Knoedler S, Deniz C, Safi A. Surface modification of PEEK implants for craniofacial reconstruction and aesthetic augmentation—fiction or reality? Frontiers In Surgery 2024, 11: 1351749. PMID: 38481611, PMCID: PMC10936457, DOI: 10.3389/fsurg.2024.1351749.Peer-Reviewed Original ResearchCraniofacial surgeryReduce complicationsCraniofacial reconstructionPatient-specific PEEK implantsPolyetheretherketone implantPolyetheretherketone patient-specific implantSystematic reviewPEEK implantsPatient-specific implantsFacial augmentationImplant failureClinical evaluationReconstructive surgerySurgeryComplicationsHuman studiesImaging modalitiesAesthetic surgeryClinical applicationLong-term studiesImplantationImplant materialsImplantologyPromote osseointegrationImprove osseointegration
2023
Impact of sarcopenia on outcomes in surgical patients: a systematic review and meta-analysis
Knoedler S, Schliermann R, Knoedler L, Wu M, Hansen F, Matar D, Obed D, Vervoort D, Haug V, Hundeshagen G, Paik A, Kauke-Navarro M, Kneser U, Pomahac B, Orgill D, Panayi A. Impact of sarcopenia on outcomes in surgical patients: a systematic review and meta-analysis. International Journal Of Surgery 2023, 109: 4238-4262. PMID: 37696253, PMCID: PMC10720826, DOI: 10.1097/js9.0000000000000688.Peer-Reviewed Original ResearchImpact of sarcopeniaPostoperative outcomesComplication occurrenceSurgical patientsSystematic reviewHospital stayPrognostic valueSubgroup analysisSurvival rateClavien-Dindo classification systemImportance of sarcopeniaFrequency of complicationsPoor postoperative outcomesInflammatory bowel diseaseSignificant predictorsHigh-quality studiesMeta-Analyses (PRISMA) guidelinesProspective study designPubMed/MEDLINESkeletal muscle massPreferred Reporting ItemsLength of operationLower survival rateSarcopenic patientsPerioperative riskNodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review
Bernasconi M, Bilic A, Kauke-Navarro M, Safi A. Nodal tumor volume as a prognostic factor for oral squamous cell carcinoma—a systematic review. Frontiers In Oral Health 2023, 4: 1229931. PMID: 37654649, PMCID: PMC10467257, DOI: 10.3389/froh.2023.1229931.Peer-Reviewed Original ResearchOral squamous cell carcinomaNodal tumor volumeSquamous cell carcinomaPrognostic factorsPrognostic significanceCell carcinomaTumor volumeSystematic reviewAccurate nodal stagingLymph node metastasisNodal disease burdenNovel prognostic factorPoor survival outcomesPoor survival rateTraditional staging methodsNode metastasisSurvival outcomesNodal stagingDisease burdenInclusion criteriaPrognostic assessmentOSCC managementElectronic databasesSurvival rateMajority of studies
2021
A systematic review of immunomodulatory strategies used in skin-containing preclinical vascularized composite allotransplant models
Kauke M, Safi AF, Panayi AC, Palmer WJ, Haug V, Kollar B, Nelms L, Tchiloemba B, Pomahac B. A systematic review of immunomodulatory strategies used in skin-containing preclinical vascularized composite allotransplant models. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 586-604. PMID: 34895853, DOI: 10.1016/j.bjps.2021.11.003.Peer-Reviewed Original ResearchConceptsSystematic reviewImmunomodulatory strategiesPreclinical researchAvailable immunosuppressive regimensCurrent standard regimenSystemic side effectsDrug-based approachesMeta-Analyses (PRISMA) guidelinesVCA modelPreferred Reporting ItemsHind limb modelNovel immunomodulatoryRejection episodesAcute rejectionImmunosuppressive regimensStandard regimenAllograft acceptanceAlloimmune responseSuppression therapyImmunomodulation strategiesLimb transplantsPreclinical modelsRat modelHuman trialsTherapeutic approachesLong-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature
Tchiloemba B, Kauke M, Haug V, Abdulrazzak O, Safi AF, Kollar B, Pomahac B. Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature. Transplantation 2021, 105: 1869-1880. PMID: 33148976, DOI: 10.1097/tp.0000000000003513.Peer-Reviewed Original ResearchConceptsSystematic reviewAcute cell-mediated rejectionPositive risk-benefit ratioRecurrent acute rejection episodesLong-term outcome dataAcute rejection episodesChronic vascular rejectionFirst year posttransplantImmunosuppression-related complicationsCell-mediated rejectionSingle-center experiencePubMed/MEDLINE databaseLong-term outcomesRisk-benefit ratioEnglish full-text articlesQuality of lifeFull-text articlesAcute rejectionAllograft lossChronic rejectionRejection episodesVascular rejectionInfectious complicationsInfectious episodesMetabolic complicationsThree-Dimensional Osteosynthesis Plates for the Surgical Treatment of Mandibular Fractures
Khalil S, Khamis H, Kauke M, Iizuka T, Safi AF. Three-Dimensional Osteosynthesis Plates for the Surgical Treatment of Mandibular Fractures. Journal Of Craniofacial Surgery 2021, 32: e728-e735. PMID: 34172684, DOI: 10.1097/scs.0000000000007709.Peer-Reviewed Original ResearchConceptsAdditional surgical interventionMandibular fracturesPostoperative complicationsMajor complicationsRetrospective studySurgical interventionSystematic reviewPlate fractureAge of patientsEffective treatment modalityNumber of patientsRisk of biasComprehensive electronic searchCochrane HandbookSurgical treatmentClinical outcomesStability of osteosynthesisProspective studyWound dehiscenceOutcome parametersTreatment modalitiesMandible fracturesLower incidenceHigh riskFracture classification
2020
Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review
Safi AF, Kauke M, Nelms L, Palmer WJ, Tchiloemba B, Kollar B, Haug V, Pomahač B. Local immunosuppression in vascularized composite allotransplantation (VCA): A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 327-335. PMID: 33229219, DOI: 10.1016/j.bjps.2020.10.003.Peer-Reviewed Original ResearchConceptsLocal immunosuppressionSystematic reviewAllograft survivalComposite allotransplantationAllograft survival dataCell-based therapy strategiesImproved allograft survivalMain immunosuppressive agentMeta-Analyses (PRISMA) guidelinesPreclinical animal studiesPreferred Reporting ItemsMalignant side effectsImmunosuppressive agentsPreclinical dataSignificant prolongationRat modelHuman trialsExclusion criteriaImmunosuppressionSide effectsAnimal studiesReporting ItemsPubMed databaseSystemic toxicityTherapy strategiesMucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review.
Kauke M, Safi AF, Zhegibe A, Haug V, Kollar B, Nelms L, Palmer WJ, Tchiloemba B, Lian CG, Murphy GF, Pomahac B. Mucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review. Transplantation 2020, 104: 2616-2624. PMID: 32053572, DOI: 10.1097/tp.0000000000003171.Peer-Reviewed Original ResearchConceptsMucosal rejectionSystematic reviewRejection gradeMucosal biopsiesPatient managementComposite allotransplantationDiagnosis of rejectionFunction of patientsFacial Vascularized Composite AllotransplantationMeta-Analyses (PRISMA) guidelinesMEDLINE/PubMedPreferred Reporting ItemsVascularized Composite AllotransplantationPosttransplant periodBiopsy gradeSkin rejectionMucosa biopsiesAllograft skinAnimal studiesReporting ItemsBiopsyRejection processFacial allotransplantsMucosaTarget tissues