2004
Fibroblast Growth Factor 7: An Inhibitor of Phosphate Transport Derived from Oncogenic Osteomalacia-Causing Tumors
Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R. Fibroblast Growth Factor 7: An Inhibitor of Phosphate Transport Derived from Oncogenic Osteomalacia-Causing Tumors. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 1012-1020. PMID: 15562028, DOI: 10.1210/jc.2004-0357.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone NeoplasmsCD4 AntigensCell Line, TumorChildCulture Media, ConditionedFibroblast Growth Factor 7Fibroblast Growth Factor-23Fibroblast Growth FactorsGene Expression RegulationHumansInsulin-Like Growth Factor Binding Protein 4KineticsMaleMiddle AgedOsteomalaciaPhosphate Transport ProteinsConceptsFibroblast growth factor 7Tumor-derived culturesOncogenic osteomalaciaInhibitory activityRenal tubular epithelial cellsTubular epithelial cellsRenal phosphate transportPhosphate transportGrowth factor 7Tumor cell culturesRenal phosphate homeostasisNonconditioned mediumTumorsMonoclonal antibodiesEpithelial cellsDirect inhibitorFactor 7Phosphate homeostasisFGF familySyndromeCandidate mRNAsPotent inhibitorInhibitorsTransport inhibitionInhibitory
1988
Renal phosphate transport in humoral hypercalcemia of malignancy
Sartori L, Insogna KL, Barrett PQ. Renal phosphate transport in humoral hypercalcemia of malignancy. American Journal Of Physiology 1988, 255: f1078-f1084. PMID: 2974244, DOI: 10.1152/ajprenal.1988.255.6.f1078.Peer-Reviewed Original ResearchConceptsLeydig cell tumorHumoral hypercalcemiaOnset of hypercalcemiaTumor-bearing animalsPhosphate metabolismRenal phosphate transportCortical brush border membraneParathyroid hormoneDaily injectionsTumor transplantationCell tumorsDichloromethylene diphosphonateMicrovillus membrane vesiclesRenal cortexRenal cortical brush border membraneSodium-dependent phosphate uptakeFisher ratsAnimal modelsPersistent impairmentHypercalcemiaLow-affinity systemBrush border membraneSpecific decreaseMalignancyRats