2013
Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element
Thomas C, Yao G, O'Brien K, Kerstetter J, Insogna K. Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element. The FASEB Journal 2013, 27: lb284-lb284. DOI: 10.1096/fasebj.27.1_supplement.lb284.Peer-Reviewed Original ResearchIntestinal iron absorptionIron absorptionDietary proteinProtein dietMRNA expressionWhole-body iron homeostasisDuodenum of ratsDMT1 mRNA expressionBody iron homeostasisGenetic absenceExperimental animalsLevel of expressionResponsive elementBrush border membraneRatsIron-responsive elementRecent dataDietCritical regulatorIron homeostasisBorder membraneSignificant changesExpressionIron importerAnimals
1999
A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo
Grey A, Mitnick M, Masiukiewicz U, Sun B, Rudikoff S, Jilka R, Manolagas S, Insogna K. A Role for Interleukin-6 in Parathyroid Hormone-Induced Bone Resorption in Vivo. Endocrinology 1999, 140: 4683-4690. PMID: 10499526, DOI: 10.1210/endo.140.10.7036.Peer-Reviewed Original ResearchConceptsParathyroid hormoneInterleukin-6Bone resorptionBiochemical markersPTH infusionEffect of PTHIL-6 productionCytokine interleukin-6Bone-resorbing cellsRelease of calciumPrimary hyperparathyroidismSerum levelsOsteoblastic cellsParacrine agentsCalcium homeostasisExperimental animalsPermissive roleChronic deficiencyResorptionImportant mediatorSystemic levelsBone formationRegulatory effectsInfusionMarkers
1992
The Effects of Isotretinoin on the Axial Skeleton and the Retinoid Effect-Reply
Milstone L, Insogna K. The Effects of Isotretinoin on the Axial Skeleton and the Retinoid Effect-Reply. JAMA Dermatology 1992, 128: 1650-1650. DOI: 10.1001/archderm.1992.04530010086018.Commentaries, Editorials and LettersSecondary hyperparathyroidismBone demineralizationEffect of isotretinoinDisorders of keratinizationRole of retinoidsExtraskeletal calcificationHypervitaminosis ACompression fracturesIndex patientsExperimental animalsLoss of calciumRetinoidsLong bonesHyperparathyroidismAxial skeletonPatientsIngestionBoneDemineralizationIsotretinoinOsteopeniaHumansLucencyCalcificationKeratinization