2020
Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China
Xing Y, Lin Q, Tong Y, Zhou W, Huang J, Wang Y, Huang G, Li Y, Xiang Z, Zhou Z, Li T, Xiao Y. Abnormal Neutrophil Transcriptional Signature May Predict Newly Diagnosed Latent Autoimmune Diabetes in Adults of South China. Frontiers In Endocrinology 2020, 11: 581902. PMID: 33391182, PMCID: PMC7775642, DOI: 10.3389/fendo.2020.581902.Peer-Reviewed Original ResearchConceptsSex-matched healthy controlsLADA patientsHealthy controlsDevelopment of LADAPathological processesPeripheral blood neutrophilsCytokine-cytokine receptor interactionReal-time polymerase chain reactionLatent AutoimmuneAdhesion molecule signalingAutoimmune diabetesFunction deteriorationNeutrophil numbersPeripheral neutrophilsBlood neutrophilsPolymerase chain reactionPathological alterationsCell differentiationLeukocyte degranulationMyeloid cell differentiationGenomes (KEGG) pathway enrichmentPatientsPresent study resultsNeutrophilsTranscriptional level
2013
Connective tissue growth factor induces osteogenic differentiation of vascular smooth muscle cells through ERK signaling
HUANG J, HUANG H, WU M, LI J, XIE H, ZHOU H, LIAO E, PENG Y. Connective tissue growth factor induces osteogenic differentiation of vascular smooth muscle cells through ERK signaling. International Journal Of Molecular Medicine 2013, 32: 423-429. PMID: 23722620, DOI: 10.3892/ijmm.2013.1398.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCalcification, PhysiologicCell TransdifferentiationConnective Tissue Growth FactorCore Binding Factor Alpha 1 SubunitExtracellular Signal-Regulated MAP KinasesGene Expression RegulationMiceMuscle, Smooth, VascularMyocytes, Smooth MuscleOsteocytesOsteogenesisSignal TransductionConceptsConnective tissue growth factorTissue growth factorVSMC calcificationRole of CTGFSmooth muscle specific αGrowth factorCalcification of VSMCsVascular smooth muscle cell growthVascular smooth muscle cellsSmooth muscle cell growthPathogenesis of atherosclerosisMouse thoracic aortaSmooth muscle cellsMuscle cell growthERK-specific inhibitorAlkaline phosphataseVascular calcificationExtracellular signal-regulated kinase (ERK) activityThoracic aortaVSMC transdifferentiationBone markersAlizarin Red S stainingTranscription factor 2Primary VSMCsMuscle cells