1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1997
Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study.
Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, Fehlings M, Herr DL, Hitchon PW, Marshall LF, Nockels RP, Pascale V, Perot PL, Piepmeier J, Sonntag VK, Wagner F, Wilberger JE, Winn HR, Young W. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 1997, 277: 1597-604. PMID: 9168289, DOI: 10.1001/jama.277.20.1597.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNational Acute Spinal Cord Injury StudyFunctional Independence MeasureHours of injuryCord injuryTirilazad groupRegimen groupMethylprednisolone infusionAcute Spinal Cord Injury StudySpinal Cord Injury StudySpinal cord injury centerEfficacy of methylprednisoloneImproved motor recoveryMotor recovery rateAdministration of methylprednisoloneMotor function changesSteroid therapyMethylprednisolone groupSevere sepsisTirilazad mesylateMotor recoveryControlled TrialsInitial presentationIntravenous bolus
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1990
A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1988
Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma
Hufnagel T, Kim J, Lesser R, Miller J, Abrahams J, Piepmeier J, Manuelidis E. Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma. JAMA Ophthalmology 1988, 106: 1701-1705. PMID: 3196211, DOI: 10.1001/archopht.1988.01060140873031.Peer-Reviewed Original Research
1987
Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres.
Piepmeier J. Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres. Journal Of Neurosurgery 1987, 67: 177-81. PMID: 3598677, DOI: 10.3171/jns.1987.67.2.0177.Peer-Reviewed Original ResearchConceptsLow-grade astrocytic tumorsComputerized tomographyCerebral hemispheresAstrocytic tumorsPreoperative neurological examinationUse of CTCurrent treatment methodsTreatment methodsPatient ageNeurological examinationTotal resectionTumor locationCurrent treatmentIntravenous administrationCT scanEarly diagnosisSurvival timeTumor enhancementContrast materialOptimal managementOnly factorPatientsLesionsOutcome statisticsTumorsCardiovascular abnormalities accompanying acute spinal cord injury in humans: Incidence, time course and severity
Lehmann K, Lane J, Piepmeier J, Batsford W. Cardiovascular abnormalities accompanying acute spinal cord injury in humans: Incidence, time course and severity. Journal Of The American College Of Cardiology 1987, 10: 46-52. PMID: 3597994, DOI: 10.1016/s0735-1097(87)80158-4.Peer-Reviewed Original ResearchConceptsCord injurySpinal cordCardiovascular abnormalitiesAcute spinal cord injuryAcute severe injuryCervical cord injuryPrimary cardiac arrestCervical spinal cordSpinal cord injuryLife-threatening disturbancesMild cervical injuriesPersistent bradycardiaAutonomic imbalanceCervical cordHemodynamic abnormalitiesInjury groupSympathetic pathwaysConsecutive patientsCord traumaCervical injuryAcute injurySupraventricular arrhythmiasCardiac arrestSevere injuriesDay 4
1983
Laminar distributions of 2-deoxyglucose uptake in the rat spinal cord following electrical stimulation of the sciatic nerve
Piepmeier J, Kauer J, Greer C. Laminar distributions of 2-deoxyglucose uptake in the rat spinal cord following electrical stimulation of the sciatic nerve. Brain Research 1983, 259: 167-171. PMID: 6824931, DOI: 10.1016/0006-8993(83)91083-1.Peer-Reviewed Original Research
1982
Delayed Post-traumatic Extracerebral Hematomas
PIEPMEIER J, WAGNER F. Delayed Post-traumatic Extracerebral Hematomas. Journal Of Trauma And Acute Care Surgery 1982, 22: 455-460. PMID: 7086910, DOI: 10.1097/00005373-198206000-00003.Peer-Reviewed Original Research