2017
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovascular Diabetology 2017, 16: 120. PMID: 28962617, PMCID: PMC5622555, DOI: 10.1186/s12933-017-0604-9.Peer-Reviewed Original ResearchConceptsAtrial fibrillationOxidative stressCommon sustained cardiac arrhythmiaMaintenance of AFSustained cardiac arrhythmiaDiabetic heartElectrical remodelingRisk factorsAtrial excitabilityTherapeutic strategiesCardiac arrhythmiasInflammationCentral mediatorObesityDiabetesFibrillationMechanistic linkMellitusArrhythmiasExcitability
2010
Pericardial Fat Is Independently Associated With Human Atrial Fibrillation
Al Chekakie M, Welles CC, Metoyer R, Ibrahim A, Shapira AR, Cytron J, Santucci P, Wilber DJ, Akar JG. Pericardial Fat Is Independently Associated With Human Atrial Fibrillation. Journal Of The American College Of Cardiology 2010, 56: 784-788. PMID: 20797492, DOI: 10.1016/j.jacc.2010.03.071.Peer-Reviewed Original ResearchConceptsPericardial fat volumeParoxysmal atrial fibrillationPersistent atrial fibrillationAtrial fibrillationPericardial fatFat volumeAtrial enlargementSinus rhythmPathogenesis of AFSinus rhythm groupTraditional risk factorsVentricular ejection fractionValvular heart diseaseBody mass indexVisceral adipose tissuePersistent AF patientsHuman atrial fibrillationAF independentAF patientsDiabetes mellitusEjection fractionMass indexHeart diseaseRisk factorsInflammatory properties