1997
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis
Mach F, Schönbeck U, Sukhova G, Bourcier T, Bonnefoy J, Pober J, Libby P. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 1931-1936. PMID: 9050882, PMCID: PMC20020, DOI: 10.1073/pnas.94.5.1931.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, T-LymphocyteArteriosclerosisBlotting, WesternB-LymphocytesCD40 AntigensCD40 LigandCells, CulturedEndothelium, VascularFlow CytometryGene Expression RegulationHumansImmunohistochemistryInterferon-gammaInterleukin-1MacrophagesMembrane GlycoproteinsMuscle, Smooth, VascularRNA, MessengerSignal TransductionTumor Necrosis Factor-alphaConceptsHuman vascular endothelial cellsSmooth muscle cellsVascular endothelial cellsHuman atherosclerotic lesionsHuman macrophagesCell typesEndothelial cellsMuscle cellsHuman vascular smooth muscle cellsVascular smooth muscle cellsDe novo synthesisCD40 ligandBroad functionsAtherosclerotic lesionsCD40 SignalingTumor necrosis factor alphaFunctional CD40 ligandInvolvement of inflammationCultured human vascular endothelial cellsCD40-CD40 ligandNovo synthesisNecrosis factor alphaParacrine activationNormal arterial tissueNovel source
1996
IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.
Palmer-Crocker RL, Hughes CC, Pober JS. IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain. Journal Of Clinical Investigation 1996, 98: 604-609. PMID: 8698849, PMCID: PMC507467, DOI: 10.1172/jci118829.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedEndothelium, VascularHumansInterleukin-3Interleukin-4Janus Kinase 2Molecular Sequence DataPhosphorylationProtein-Tyrosine KinasesProto-Oncogene ProteinsReceptors, Interleukin-2RNA, MessengerSTAT6 Transcription FactorTrans-ActivatorsTyrosineVascular Cell Adhesion Molecule-1ConceptsIL-4 responsesIL-13IL-4Human endothelial cellsEndothelial cellsVascular cell adhesion molecule-1Cell adhesion molecule-1Cultured human vascular endothelial cellsAdhesion molecule-1IL-15 receptorTyrosine kinaseCommon signaling subunitHuman vascular endothelial cellsJAK2 tyrosine kinaseVascular endothelial cellsSTAT6 transcription factorReverse transcription-PCR methodGamma c chainTranscription-PCR methodGC-independent pathwayIL-2IL-9IL-7IL-4RMolecule-1
1985
Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.
Bevilacqua MP, Pober JS, Wheeler ME, Cotran RS, Gimbrone MA. Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. American Journal Of Pathology 1985, 121: 394-403. PMID: 3878084, PMCID: PMC1887931.Peer-Reviewed Original ResearchConceptsInterleukin-1Procoagulant activityHuman endothelial cellsEndothelial cellsVascular endotheliumTissue factor-like procoagulant activityLeukocyte adhesionPeripheral blood polymorphonuclear leukocytesHuman peripheral blood polymorphonuclear leukocytesCultured human vascular endothelial cellsBlood polymorphonuclear leukocytesIL-1 actionIL-1 effectsRecombinant IL-1Sites of inflammationHuman vascular endothelial cellsInterleukin-1 activationVascular endothelial cellsEnhanced leukocyteIntravascular coagulationImmune mediatorsIL-2Saphenous veinEndothelial cell surfaceUmbilical vein
1984
Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens
Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss C, Burakoff SJ. Interactions of T Lymphocytes with Human Vascular Endothelial Cells: Role of Endothelial Cells Surface Antigens. Immunobiology 1984, 168: 483-494. PMID: 6397428, DOI: 10.1016/s0171-2985(84)80132-1.Peer-Reviewed Original ResearchConceptsClass II antigensVascular endothelial cellsMajor histocompatibility complexII antigensT cellsClass II moleculesHuman vascular endothelial cellsActivated T cellsEndothelial cellsStromal cellsImmune interferonT lymphocytesAntigen-specific T cellsPeripheral blood T lymphocytesClass IHelper T cell clonesImmune accessory functionNon-MHC antigensWithdrawal of interferonClass II major histocompatibility complexCultured human vascular endothelial cellsT cell responsesVascular smooth muscle cellsBlood T lymphocytesHuman class II antigens