2024
Semaglutide utilization associated with reduced ninety-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Varthi A, Rubio D, Grauer J. Semaglutide utilization associated with reduced ninety-day postoperative complications following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024 PMID: 39491749, DOI: 10.1016/j.spinee.2024.10.011.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsAdverse eventsPostoperative complicationsT2DM patientsCurrent Procedural TerminologyElixhauser Comorbidity IndexED visitsLumbar fusionHospital readmissionEmergency departmentOdds of postoperative complicationsNinety-day postoperative complicationsImpact of semaglutideOdds of hospital readmissionMonths of surgeryRetrospective cohort studyPostoperative adverse eventsMinor adverse eventsType II diabetes mellitusRisk of type I errorDiagnosis of T2DMII diabetes mellitusYears of ageInflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to biologics
Seddio A, Katsnelson B, Smith-Voudouris J, Gouzoulis M, Day W, Jabbouri S, Vasudevan R, Rubio D, Grauer J. Inflammatory bowel disease is associated with greater odds of complications following posterior lumbar fusion and further amplified for patients exposed to biologics. North American Spine Society Journal (NASSJ) 2024, 100574. DOI: 10.1016/j.xnsj.2024.100574.Peer-Reviewed Original ResearchPosterior lumbar fusionInflammatory bowel diseaseOdds ratioNational Inpatient SampleElixhauser Comorbidity IndexLumbar fusionBowel diseaseKaplan-Meier survival analysisEmergency departmentInflammatory bowel disease patientsLog-rank testMinor adverse eventsNon-IBD patientsIn-hospital dataMultivariate logistic regressionAssociated with greater oddsElevated odds ratiosReoperation rateSurgical complicationsSpine surgeryInferior outcomesPearlDiver databasePost-discharge outcomesAdult patientsAdverse eventsLower Risk of Postoperative Complications and Rotator Cuff Retear Associated with Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair
Seddio A, Moran J, Gouzoulis M, Garbis N, Salazar D, Grauer J, Jimenez A. Lower Risk of Postoperative Complications and Rotator Cuff Retear Associated with Semaglutide Use in Patients with Type II Diabetes Mellitus Undergoing Arthroscopic Rotator Cuff Repair. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2024 PMID: 39490542, DOI: 10.1016/j.arthro.2024.09.057.Peer-Reviewed Original ResearchArthroscopic rotator cuff repairT2DM patientsRotator cuff retearRotator cuff repairElixhauser Comorbidity IndexAdverse eventsLow risk of postoperative complicationsOdds ratioRisk of postoperative complicationsKaplan-Meier survival analysisUrinary tract infectionSurgical-site infectionCuff repairLog-rank testRetrospective comparative studyAcute kidney injuryMinor adverse eventsType II diabetes mellitusAssociated with decreased oddsMultivariate logistic regressionArthroscopic shoulder proceduresII diabetes mellitusAdministrative billing codesPostoperative complicationsTract infectionsPatients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair
Rancu A, Katsnelson B, Sanchez J, Winter A, Vasudevan R, Grauer J. Patients with fibromyalgia have increased risk of 90-day postoperative adverse events following arthroscopic rotator cuff repair. JSES International 2024 DOI: 10.1016/j.jseint.2024.09.018.Peer-Reviewed Original ResearchRotator cuff repairPostoperative adverse eventsAdverse eventsArthroscopic rotator cuff repairCurrent Procedural TerminologyElixhauser Comorbidity IndexOccurrence of wound dehiscenceEmergency departmentUrinary tract infectionSymptomatic rotator cuff tearsAssociated with increased riskCuff repairLog-rank testYear of surgerySurgical site infectionSevere adverse eventsKaplan-Meier curvesAcute kidney injuryOccurrence of sepsisDeep vein thrombosisMinor adverse eventsRotator cuff repair patientsIndividual adverse eventsOdds of ED utilizationDiagnosis of fibromyalgia90-Day Complication and Readmission Rates for Geriatric Patients With Hip Fracture at Different Time Points From COVID-19 Positivity: A Database Study
Sanchez J, Jiang W, Dhodapkar M, Radford Z, Rubin L, Grauer J. 90-Day Complication and Readmission Rates for Geriatric Patients With Hip Fracture at Different Time Points From COVID-19 Positivity: A Database Study. JAAOS Global Research And Reviews 2024, 8: e24.00069. PMID: 39330875, PMCID: PMC11412709, DOI: 10.5435/jaaosglobal-d-24-00069.Peer-Reviewed Original ResearchConceptsHip fracture surgeryHip fractureGeriatric patientsFracture surgeryAdverse eventsRate of minor adverse eventsCOVID-19 diagnosisWeeks of surgeryMinor adverse eventsTime pointsAssociated with increased oddsComplication rateAssess complicationsCOVID-19 positivityCOVID-19 infectionMultivariate analysisSurgeryComplicationsPatientsDatabase studyReadmission ratesCare algorithmWeeksDiagnosisCOVID-19P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy
Gouzoulis M, Seddio A, Zhu J, Day W, Jabbouri S, Rubio D, Grauer J. P27. Renal transplant patients at increased odds off many perioperative adverse events following lumbar laminotomy/discectomy. The Spine Journal 2024, 24: s76. DOI: 10.1016/j.spinee.2024.06.048.Peer-Reviewed Original ResearchSevere adverse eventsHistory of renal transplantationUrinary tract infectionRenal transplantationAcute kidney injuryAdverse eventsMinor adverse eventsElixhauser Comorbidity IndexIncreased oddsCurrent Procedural TerminologyTract infectionsLumbar discectomyKidney injuryED visitsIncreased odds of acute kidney injuryOdds of acute kidney injuryOdds ratioOdds of ED visitsKaplan-Meier survival curvesDays of follow-upRenal transplant groupRenal transplant patientsIncidence of reoperationRisk of reoperationOdds of sepsisP31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy
Seddio A, Gouzoulis M, Smith-Voudouris J, Rubio D, Day W, Grauer J. P31. Testosterone replacement therapy associated with increased 90-day postoperative adverse events and 5-year reoperation following lumbar discectomy. The Spine Journal 2024, 24: s78. DOI: 10.1016/j.spinee.2024.06.052.Peer-Reviewed Original ResearchTestosterone replacement therapyAcute kidney injuryLumbar discectomyAdverse eventsMale patientsOdds ratioCurrent Procedural TerminologyReoperation ratePostoperative outcomesElixhauser Comorbidity IndexPostoperative recoveryMultivariate analysisSingle-level lumbar discectomyTestosterone replacement therapy patientsMyocardial infarctionOrthopedic surgeryKaplan-Meier survival analysisEmergency departmentLumbar spinal proceduresLog-rank testMonths of surgeryRetrospective cohort studyPostoperative adverse eventsEnhanced postoperative recoveryMinor adverse events35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients
Seddio A, McNamara K, Gouzoulis M, Jabbouri S, Ratnasamy P, Rubio D, Grauer J. 35. Comparable risk of adverse events following cervicothoracic interlaminar and transforaminal epidural injections: an analysis of 1.29 million patients. The Spine Journal 2024, 24: s19. DOI: 10.1016/j.spinee.2024.06.478.Peer-Reviewed Original ResearchAdverse eventsSpinal neurologic deficitsStatistically significant differenceCurrent Procedural TerminologyElixhauser Comorbidity IndexEpidural injectionAdult patientsNeurological deficitsAdverse outcomesMultivariate analysisED visitsIncidence of adverse eventsEpidural spinal injectionsTransforaminal epidural injectionsEmergency departmentTransforaminal (TFRisk of adverse eventsSignificant differenceRetrospective cohort studyMinor adverse eventsSampled adult patientsOutcome measures IncidencePotential adverse eventsSpinal injectionPatient age100. Semaglutide associated with improved postoperative outcomes following single-level posterior lumbar fusion for patients with type II diabetes
Seddio A, Gouzoulis M, Vasudevan R, Dhodapkar M, Jabbouri S, Zhu J, Rubio D, Grauer J. 100. Semaglutide associated with improved postoperative outcomes following single-level posterior lumbar fusion for patients with type II diabetes. The Spine Journal 2024, 24: s52-s53. DOI: 10.1016/j.spinee.2024.06.543.Peer-Reviewed Original ResearchSingle-level posterior lumbar fusionPosterior lumbar fusionSodium-glucose transport protein 2 inhibitorsImpact of semaglutideHospital readmissionPostoperative outcomesElixhauser Comorbidity IndexED visitsT2DM patientsCurrent Procedural TerminologyEmergency departmentLumbar fusionAdverse eventsOdds of hospital readmissionOutcome measures IncidenceRisk of type I errorInferior postoperative outcomesDiagnosis of T2DMMonths of surgeryYear of surgeryRetrospective cohort studyMinor adverse eventsType II diabetes mellitusMatched 1:4Management of diabetesOutcomes following two-level Cervical Disc Arthroplasty Relative to two-level Anterior Cervical Discectomy.
Ratnasamy P, Gouzoulis M, Jabbouri S, Varthi A, Grauer J. Outcomes following two-level Cervical Disc Arthroplasty Relative to two-level Anterior Cervical Discectomy. Spine 2024 PMID: 39190404, DOI: 10.1097/brs.0000000000005131.Peer-Reviewed Original ResearchCervical disc arthroplasty patientsFive-year survivalCervical disc arthroplastyPostoperative adverse eventsSpine reoperationTwo-level cervical disc arthroplastyAdverse eventsACDF patientsPatient ageElixhauser Comorbidity IndexTreatment optionsMultivariate analysisDegenerative cervical spine pathologyTwo-level surgeryCervical spine pathologyTwo-level ACDFAnterior cervical discectomyNovel treatment optionsMinor adverse eventsCervical discectomyNo significant differenceSpine pathologyACDFReoperationComorbidity indexAnkle fracture open reduction and internal fixation in patients with cerebral palsy
Dhodapkar M, Yang A, Jiang W, Halperin S, Frumberg D, Grauer J. Ankle fracture open reduction and internal fixation in patients with cerebral palsy. Developmental Medicine & Child Neurology 2024, 66: 1496-1501. PMID: 38773804, DOI: 10.1111/dmcn.15958.Peer-Reviewed Original ResearchAnkle fracture ORIFCerebral palsyAnkle fracturesElixhauser Comorbidity IndexInternational Classification of Diseases (ICD)-9 and ICD-10Increased oddsIsolated ankle fracturesEmergency department visitsClosed ankle fracturesInternal fixationProlonged lengthMultivariate logistic regressionAnkle fracture open reductionProlonged length of stayDepartment visitsLength of stayInternational ClassificationAdverse eventsStudy of adult patientsFracture open reductionMinor adverse eventsICD-10Logistic regressionORAnkleIncreased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty
Sanchez J, Rancu A, Diatta F, Jonnalagadda A, Dhodapkar M, Knoedler L, Kauke-Navarro M, Grauer J. Increased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00102. PMID: 38722914, PMCID: PMC11081627, DOI: 10.5435/jaaosglobal-d-24-00102.Peer-Reviewed Original ResearchConceptsRevision-free survivalDay of surgeryAdverse eventsTSA patientsIncreased riskMultivariate analysisOdds ratioIncreased risk of adverse eventsUrinary tract infectionLog-rank testRisk of adverse eventsSurgical site infectionSevere adverse eventsEffective treatment optionAcute kidney injuryDeep vein thrombosisMinor adverse eventsNon-fibromyalgia patientsEnd-stage glenohumeral osteoarthritisAssociation of fibromyalgiaIncreased odds ratioTotal shoulder arthroplastyShoulder infectionPulmonary embolismTract infectionsRobotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion
Gouzoulis M, Seddio A, Winter A, Jabbouri S, Zhu J, Rubio D, Varthi A, Grauer J. Robotic-Assisted Versus Navigation-Assisted Posterior Lumbar Fusion. Spine 2024, 49: 1483-1487. PMID: 38717329, DOI: 10.1097/brs.0000000000005032.Peer-Reviewed Original ResearchPosterior lumbar fusionLumbar fusionAdverse eventsLevel posterior lumbar fusionsCPT codesKaplan-Meier survival analysisRate of reoperationNavigation-assisted surgeryRobotic-assisted casesNavigation-assistedMinor adverse eventsPerioperative adverse eventsMultivariate logistic regressionICD-10 procedure codeRobotic cohortRobotic assistanceSpinal navigationReoperation rateAnterior fusionElixhauser Comorbidity IndexPearlDiver databaseNo significant differenceIncremental advantageAdverse outcomesComorbidity index
2023
Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease
Dhodapkar M, Halperin S, Saifi C, Whang P, Grauer J, Varthi A. Ninety day adverse events following single level posterior lumbar interbody fusion in patients with sickle cell disease. The Spine Journal 2023, 24: 807-811. PMID: 38081460, DOI: 10.1016/j.spinee.2023.11.025.Peer-Reviewed Original ResearchPosterior lumbar interbody fusionSingle-level posterior lumbar interbody fusionSickle cell diseaseElixhauser Comorbidity IndexAdverse eventsPostoperative outcomesInterbody fusionOdds ratioCell diseaseDays adverse eventsMinor adverse eventsPostoperative adverse eventsPerioperative adverse eventsSevere adverse eventsCohort of patientsED visit ratesEmergency department visitsMultivariable logistic regressionNational administrative databaseRetrospective database studyLumbar interbody fusionSingle level posteriorComorbidity indexPLIF patientsAdult patientsPatients With Down Syndrome and Total Hip and Total Knee Arthroplasty: Outcome Measures Show Increased Risk of Perioperative Complications
Halperin S, Dhodapkar M, Radford Z, Frumberg D, Rubin L, Grauer J. Patients With Down Syndrome and Total Hip and Total Knee Arthroplasty: Outcome Measures Show Increased Risk of Perioperative Complications. JAAOS Global Research And Reviews 2023, 7: e23.00108. PMID: 38054749, PMCID: PMC10697628, DOI: 10.5435/jaaosglobal-d-23-00108.Peer-Reviewed Original ResearchConceptsTotal knee arthroplastyTotal hip arthroplastyAcute kidney injuryUrinary tract infectionAdverse eventsDown syndromePostoperative eventsKnee arthroplastyRevision ratePerioperative risk assessmentMinor adverse eventsOutcomes of patientsMultivariable logistic regressionTotal joint arthroplastyPatient/family counselingKidney injuryPerioperative complicationsTKA patientsAdult patientsTract infectionsDS patientsIncreased riskTotal hipCare pathwayJoint arthroplastyAdverse Events After Ankle Fracture Open Reduction Internal Fixation Among Patients With and Without Documented Cannabis and Tobacco Use
Dhodapkar M, Oghenesume O, Halperin S, Modrak M, Yoo B, Grauer J. Adverse Events After Ankle Fracture Open Reduction Internal Fixation Among Patients With and Without Documented Cannabis and Tobacco Use. Foot & Ankle International 2023, 44: 941-948. PMID: 37698277, DOI: 10.1177/10711007231189698.Peer-Reviewed Original ResearchConceptsOpen reduction internal fixationAnkle fracture open reduction internal fixationUrinary tract infectionMinor adverse eventsAdverse eventsReduction internal fixationRetrospective database studyTobacco useAnkle fracturesInternal fixationTobacco usersHigher oddsDatabase studyGreater oddsAnkle open reduction internal fixationElixhauser comorbidity index scoreCause adverse eventsComorbidity Index scoreSevere adverse eventsCommon orthopedic injuriesMultivariable logistic regressionStudy inclusion criteriaGroup of nonusersPerioperative outcomesAdult patientsWeight loss makes the difference: perioperative outcomes following posterior lumbar fusion in patients with and without weight loss following bariatric surgery
Dhodapkar M, Halperin S, Joo P, Maloy G, Jeong S, Rubio D, Grauer J. Weight loss makes the difference: perioperative outcomes following posterior lumbar fusion in patients with and without weight loss following bariatric surgery. The Spine Journal 2023, 23: 1506-1511. PMID: 37302416, DOI: 10.1016/j.spinee.2023.06.002.Peer-Reviewed Original ResearchConceptsHistory of BSPosterior lumbar fusionElixhauser Comorbidity IndexMorbid obesityBariatric surgeryAdverse eventsWeight lossReadmission ratesLumbar fusionSingle-level posterior lumbar fusionImpact of BSRetrospective case-control studyPrior bariatric surgeryMinor adverse eventsLevel posterior lumbar fusionTime of surgeryMultivariable logistic regressionCase-control studyHistory of infectionSignificant weight lossMO categoryMorbidly obesityPLF patientsComorbidity indexPerioperative outcomesRheumatoid arthritis patients are at increased risk for adverse events following lumbar discectomy
Ratnasamy P, Rudisill K, Gouzoulis M, Kammien A, Grauer J. Rheumatoid arthritis patients are at increased risk for adverse events following lumbar discectomy. The Spine Journal 2023, 23: 990-996. PMID: 36990283, DOI: 10.1016/j.spinee.2023.03.012.Peer-Reviewed Original ResearchConceptsLumbar discectomy patientsAdverse eventsRheumatoid arthritisLumbar discectomyPatient ageDiscectomy patientsMinor adverse eventsRetrospective cohort studyLumbar spinal surgeryPatient's medication regimenElixhauser Comorbidity IndexExclusion of patientsRA medicationsComorbidity indexCohort studyMedication regimenPrior diagnosisPredictive factorsAdverse outcomesSubgroup analysisSpinal surgeryInfection diagnosisAutoinflammatory diseasesHigher oddsDiscectomyAnterior Cervical Discectomy and Fusion Outcomes in Patients With and Without Bariatric Surgery—Weight Loss Does Make a Difference
Joo P, Zhu J, Wilhelm C, Tang K, Day W, Moran J, Grauer J. Anterior Cervical Discectomy and Fusion Outcomes in Patients With and Without Bariatric Surgery—Weight Loss Does Make a Difference. Spine 2023, 48: 400-406. PMID: 36735637, DOI: 10.1097/brs.0000000000004580.Peer-Reviewed Original ResearchConceptsAnterior cervical discectomyBariatric surgeryMorbid obesityAdverse eventsCervical discectomyReoperation rateBS proceduresFive-Year Reoperation RatesRetrospective comparative cohort studyHistory of BSMinor adverse eventsNon-obese patientsAdverse event ratesComparative cohort studyElixhauser Comorbidity IndexKaplan-Meier analysisRisk of complicationsNon-obese controlsLength of stayACDF patientsElective ACDFComorbidity indexFusion patientsPulmonary embolismCohort study
2022
Total shoulder arthroplasty: ninety-day adverse events and 5-year implant survival in patients with hidradenitis suppurativa
Gouzoulis M, Ratnasamy P, Caruana D, Wiznia D, Medvecky M, Grauer J. Total shoulder arthroplasty: ninety-day adverse events and 5-year implant survival in patients with hidradenitis suppurativa. Seminars In Arthroplasty JSES 2022, 32: 676-680. DOI: 10.1053/j.sart.2022.07.012.Peer-Reviewed Original ResearchTotal shoulder arthroplastySurgical site infectionMinor adverse eventsAdverse eventsSite infectionTSA patientsImplant survivalHS patientsSkin lesionsLog-rank Mantel-Cox testFive-year implant survivalKaplan-Meier survival curvesHigher comorbidity burdenMethods Adult patientsNon-HS groupsSevere adverse eventsElixhauser Comorbidity IndexChronic skin disorderPotential risk factorsMantel-Cox testRisk of infectionComorbidity burdenComorbidity indexPostoperative complicationsReoperation rate