2019
Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression
Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier VT, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein ML, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. Journal Of Clinical Investigation 2019, 129: 3058-3071. PMID: 31112135, PMCID: PMC6668688, DOI: 10.1172/jci122936.Peer-Reviewed Original ResearchConceptsLactation-induced bone lossParathyroid hormoneBone lossBone resorptionCathepsin KMilk calcium levelsParathyroid hormone suppressionSerum parathyroid hormoneRegulation of PTHOsteoclastic bone resorptionTrabecular bone volumeOsteocyte lacunar areaHormone suppressionHigh calcium demandOsteoclast numberCortical thicknessEffect of lactationCalcium levelsNormal rangeBone volumeCalcium demandExact mechanismLacunar areaResorptionSufficient calcium
2018
Chapter 46 Parathyroid Hormone, Parathyroid Hormone–Related Protein, and Calcitonin
Wysolmerski J. Chapter 46 Parathyroid Hormone, Parathyroid Hormone–Related Protein, and Calcitonin. 2018, 849-870. DOI: 10.1016/b978-0-12-809965-0.00046-x.Peer-Reviewed Original Research
2015
Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues
Wysolmerski J. Chapter 13 Physiological Actions of Parathyroid Hormone (PTH) and PTH-related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2015, 203-221. DOI: 10.1016/b978-0-12-397166-1.00013-8.Peer-Reviewed Original ResearchFunction of PTHrPParathyroid hormoneType 1 PTH/PTHrP receptorPTH/PTHrP receptorSystemic calcium metabolismHormone-related proteinNon-skeletal sitesSpecific G-proteinCalcium metabolismIntracrine factorParathyroid glandsPTHrP receptorSystemic hormonesPancreatic tissueEndocrine pancreasPTHrPPhysiological actionsMammary glandHormoneG proteinsTissueChondrocyte differentiationReceptorsGlandSkeletal development
2013
Parathyroid Hormone‐Related Protein
Wysolmerski J. Parathyroid Hormone‐Related Protein. 2013, 215-223. DOI: 10.1002/9781118453926.ch27.Peer-Reviewed Original ResearchMouse geneticsNormal biologyType I PTH/PTHrP receptorNormal developmentPTH/PTHrP receptorNormal physiologyAction of PTHHormone-related proteinGrowth factorProteinHumoral hypercalcemiaDiverse sitesParathyroid hormonePhysiologyPTHrP receptorPTHrPPTHSystemic actionMammalsHypercalcemiaGeneticsBiologyFishPTHrP.ReproductionParathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development
Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Specifies the Mammary Mesenchyme and Regulates Embryonic Mammary Development. Journal Of Mammary Gland Biology And Neoplasia 2013, 18: 171-177. PMID: 23640717, PMCID: PMC3696739, DOI: 10.1007/s10911-013-9283-7.BooksConceptsParathyroid hormoneBreast cancerMammary rudimentsMammary budLoss of PTHrPOverexpression of PTHrPRole of PTHrPEffects of PTHrPNovel breast cancer susceptibility lociEpithelial-stromal crosstalkEmbryonic mammary budBreast cancer susceptibility lociEmbryonic mammary developmentMammary gland morphogenesisNipple skinDay 15PTHrP’s rolePTHrPMammary developmentMammary epithelial identityMammary mesenchymeCancer susceptibility lociCancerCritical regulatorHormoneChapter 66 Disorders of Calcium Metabolism
Dumitru C, Wysolmerski J. Chapter 66 Disorders of Calcium Metabolism. 2013, 2273-2309. DOI: 10.1016/b978-0-12-381462-3.00066-5.Peer-Reviewed Original ResearchCalcium metabolismCalcium levelsParathyroid hormone-related proteinMulti-organ dysfunctionHormone-related proteinMetabolic bone disordersExtracellular calcium levelsParathyroid hormone receptorPrinciples of managementParathyroid hormoneBone metabolismBone disordersPrevalent causeCalcium homeostasisOrgan systemsHormone receptorsDisease statesHypercalcemiaHypocalcemiaDisordersNormal regulationHormoneMetabolismReceptorsCritical role
2012
Parathyroid Hormone-Related Protein: An Update
Wysolmerski JJ. Parathyroid Hormone-Related Protein: An Update. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 2947-2956. PMID: 22745236, PMCID: PMC3431578, DOI: 10.1210/jc.2012-2142.BooksConceptsType 1 PTH/PTHrP receptorPTH/PTHrP receptorCauses of hypercalcemiaCommon paraneoplastic syndromeParaneoplastic syndromeHumoral hypercalcemiaParathyroid hormonePTHrP receptorBreast cancerNormal physiological functionPTHrPDisease statesTranslational researchHypercalcemiaOsteoporosisBedsidePhysiological functionsRelated genesHyperparathyroidismBasic biologyDiabetesMalignancyOsteoarthritisSyndromePTH
2011
Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland
Boras-Granic K, VanHouten J, Hiremath M, Wysolmerski J. Parathyroid Hormone-Related Protein Is Not Required for Normal Ductal or Alveolar Development in the Post-Natal Mammary Gland. PLOS ONE 2011, 6: e27278. PMID: 22087279, PMCID: PMC3210770, DOI: 10.1371/journal.pone.0027278.Peer-Reviewed Original ResearchConceptsMammary glandPTHrP expressionAlveolar developmentMyoepithelial cellsMaternal calcium homeostasisOverexpression of PTHrPRole of PTHrPExpression of PTHrPEmbryonic mammary budPTHrP deficiencyMouse mammary glandParathyroid hormoneTransgenic miceDuctal developmentCalcium homeostasisAlveolar cellsPTHrPPubertal developmentMMTV-CrePost-natal mammary glandMammary developmentMammary budPostnatal mammary glandCre transgenePTHrP geneSkeletal recovery after weaning does not require PTHrP*
Kirby BJ, Ardeshirpour L, Woodrow JP, Wysolmerski JJ, Sims NA, Karaplis AC, Kovacs CS. Skeletal recovery after weaning does not require PTHrP*. Journal Of Bone And Mineral Research 2011, 26: 1242-1251. PMID: 21308774, PMCID: PMC3179289, DOI: 10.1002/jbmr.339.Peer-Reviewed Original ResearchConceptsBone mineral contentParathyroid hormoneBone massSerum calciumLumbar spine bone mineral contentTrabecular bone mineral contentParathyroid hormone-related proteinSpine bone mineral contentBone formationNormal serum calciumLow bone massAdult bone massPTHrP mRNA expressionWild-type miceHormone-related proteinEnd of lactationType 1 collagenUrine calciumSkeletal recoveryPTHrP mRNANull miceMRNA expressionFull recoveryMiceConditional knockoutChapter 41 Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin
Holt E, Wysolmerski J. Chapter 41 Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin. 2011, 725-745. DOI: 10.1016/b978-0-12-381978-9.10041-1.Peer-Reviewed Original ResearchParathyroid hormoneParathyroid hormone-related proteinMedullary thyroid cancerSerum tumor markersSigns of recurrenceEffect of calcitoninTreatment of osteoporosisMedullary thyroid carcinomaHormone-related proteinTreatment of boneIntermittent administrationCalcium disordersThyroid cancerSmooth muscleThyroid carcinomaAnabolic responseTumor markersUseful agentBaseline levelsPTH analogsCardiovascular systemCalcitoninGrowth factorMammary glandLongitudinal monitoring
2008
Chapter 33 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, Pancreatic Tissues
Wysolmerski J, Stewart A, Kovacs C. Chapter 33 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, Pancreatic Tissues. 2008, 713-731. DOI: 10.1016/b978-0-12-373884-4.00051-3.ChaptersFunction of PTHrPParathyroid hormoneMammary glandNonskeletal effectsPancreatic tissueTransgenic miceEndocrine pancreasPTHrPPhysiological actionsPancreasPlacentaMicePhysiological roleGlandPhysiological functioningSkinMouse geneticsReproductive tissuesTissueStudy of physiologyRemarkable moleculeUterusPhysiologyMammaryStudy
2002
Overexpression of Parathyroid Hormone‐Related Protein Causes Hypercalcemia but Not Bone Metastases in a Murine Model of Mammary Tumorigenesis*
Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of Parathyroid Hormone‐Related Protein Causes Hypercalcemia but Not Bone Metastases in a Murine Model of Mammary Tumorigenesis*. Journal Of Bone And Mineral Research 2002, 17: 1164-1170. PMID: 12096830, DOI: 10.1359/jbmr.2002.17.7.1164.Peer-Reviewed Original ResearchConceptsBone metastasesBreast cancer cellsCancer cellsTransgenic miceTumor-bearing transgenic miceParathyroid hormone-related proteinPrimary breast cancerProduction of PTHrPHormone-related proteinWild-type littermatesEffects of PTHrPCause hypercalcemiaWild-type controlsVisceral metastasesSkeletal metastasesParathyroid hormoneBone resorptionArterial circulationBreast cancerDMBA treatmentMammary carcinogenImmunodeficient miceMammary tumorigenesisMurine modelHigh incidenceChapter 29 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues
Wysolmerski J, Stewart A, Martin T. Chapter 29 Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2002, 515-530. DOI: 10.1016/b978-012098652-1.50131-1.ChaptersParathyroid hormonePhysiological actionsPlacental calcium transportOverexpression of PTHrPIntracellular calcium releaseCultured β-cellsIntracrine regulatorCalcium incrementFetal circulationEndocrine onesPancreatic tissueTransgenic miceFetal developmentFetal membranesPTHrPCalcium releaseΒ-cellsPTHrP geneBasal keratinocytesHair folliclesCalcium transportNonskeletal sitesPlacentaTransport of calciumPotential role
2001
Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction
Wysolmerski J. Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1788-1794. DOI: 10.1210/jc.86.4.1788.Peer-Reviewed Original ResearchAbsence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1
Wysolmerski J, Cormier S, Philbrick W, Dann P, Zhang J, Roume J, Delezoide A, Silve C. Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction1. The Journal Of Clinical Endocrinology & Metabolism 2001, 86: 1788-1794. PMID: 11297619, DOI: 10.1210/jcem.86.4.7404.Peer-Reviewed Original ResearchConceptsParathyroid hormoneHuman breastBreast developmentType 1 PTH/PTHrP receptorBlomstrand chondrodysplasiaPTH/PTHrP receptorAbnormal breast developmentBone formationTooth developmentNormal human fetusesTooth impactionPTHrP receptorEndochondral bone formationTransgenic miceAlveolar boneHuman fetusesEndochondral bone developmentBreastSevere abnormalitiesEpithelial-mesenchymal interactionsLethal formMammary glandFetusesBone developmentTeethChapter 17 Physiologic Actions of PTH and PTHrP V. Epidermal, Mammary, Reproductive, and Pancreatic Tissues
Wysolmerski J, Stewart A, Martin J. Chapter 17 Physiologic Actions of PTH and PTHrP V. Epidermal, Mammary, Reproductive, and Pancreatic Tissues. 2001, 275-291. DOI: 10.1016/b978-012098651-4/50019-5.ChaptersParathyroid hormonePTHrP productionPhysiologic actionsHuman keratinocytesShort regulatory loopFibroblast-conditioned mediumBioactive PTHrPDermal fibroblastsNormal human keratinocytesPancreatic tissuePTHrPPTHrP geneCultured keratinocytesMultiple studiesMature skinBasal layerKeratinocytesGranular layerSitu hybridizationSkinVariety of factorsRegulatory loopLow levelsTissue cultureFibroblasts
1999
Parathyroid Hormone-Related Protein: A Developmental Regulatory Molecule Necessary for Mammary Gland Development
Dunbar M, Wysolmerski J. Parathyroid Hormone-Related Protein: A Developmental Regulatory Molecule Necessary for Mammary Gland Development. Journal Of Mammary Gland Biology And Neoplasia 1999, 4: 21-34. PMID: 10219904, DOI: 10.1023/a:1018700502518.Peer-Reviewed Original Research
1998
Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein
Dunbar M, Young P, Zhang J, McCaughern-Carucci J, Lanske B, Orloff J, Karaplis A, Cunha G, Wysolmerski J. Stromal Cells Are Critical Targets in the Regulation of Mammary Ductal Morphogenesis by Parathyroid Hormone-Related Protein. Developmental Biology 1998, 203: 75-89. PMID: 9806774, DOI: 10.1006/dbio.1998.9029.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding, CompetitiveCyclic AMPEmbryonic and Fetal DevelopmentEpitheliumFemaleGene Expression Regulation, DevelopmentalIn Situ HybridizationMammary Glands, AnimalMesodermMiceMice, Inbred StrainsMorphogenesisParathyroid Hormone-Related ProteinProteinsReceptors, Parathyroid HormoneRNA, MessengerStromal CellsConceptsPTH/PTHrP receptorPTHrP receptorStromal cellsMammary epithelial cell morphogenesisMammary developmentEpithelial cell morphogenesisMammary glandAmino-terminal PTHrPEpithelial cellsHormone-related proteinMammary ductal morphogenesisMammary epithelial cellsCritical targetMammary stromal cellsDuctal branching morphogenesisDevelopmental regulatory moleculeStromal cell functionMurine mammary glandCell morphogenesisMammary morphogenesisHumoral hypercalcemiaParathyroid hormoneTumor productsRegulatory moleculesMammary mesenchyme
1996
Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule
Dunbar M, Wysolmerski J, Broadus A. Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule. The American Journal Of The Medical Sciences 1996, 312: 287-294. DOI: 10.1016/s0002-9629(15)41844-0.Peer-Reviewed Original ResearchConceptsDevelopmental regulatory moleculeCommon metabolic complicationHypercalcemia of malignancyHormone-related proteinParathyroid hormone receptorTypes of cancerMetabolic complicationsHumoral hypercalcemiaParathyroid hormoneRegulatory moleculesParacrine fashionBiochemical manifestationsMalignant cellsHypercalcemiaFetal tissuesPTHrPHormone receptorsNormal biological functionsMalignancyMolecular evolutionHHMBiological functionsMolecular mechanismsComplicationsKidneyParathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule
Dunbar M, Wysolmerski J, Broadus A. Parathyroid Hormone-Related Protein: From Hypercalcemia of Malignancy to Developmental Regulatory Molecule. The American Journal Of The Medical Sciences 1996, 312: 287-294. PMID: 8969618, DOI: 10.1097/00000441-199612000-00007.Peer-Reviewed Original ResearchConceptsDevelopmental regulatory moleculeCommon metabolic complicationHypercalcemia of malignancyHormone-related proteinParathyroid hormone receptorTypes of cancerMetabolic complicationsHumoral hypercalcemiaParathyroid hormoneRegulatory moleculesParacrine fashionBiochemical manifestationsMalignant cellsHypercalcemiaFetal tissuesPTHrPHormone receptorsNormal biological functionsMalignancyMolecular evolutionHHMBiological functionsMolecular mechanismsComplicationsKidney