2023
NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature
Dhodapkar R, Spadaro J, Heng J, Sinard J, Lee Y, Habib L, Pointdujour-Lim R. NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature. Ophthalmic Plastic And Reconstructive Surgery 2023, 39: 316-327. PMID: 36692957, DOI: 10.1097/iop.0000000000002317.Peer-Reviewed Original ResearchConceptsNK/T-cell lymphomaT-cell lymphomaImproved survivalOrbital involvementCases of NKTLAdvanced Ann Arbor stageAnn Arbor stageRecurrence of diseaseUse of radiotherapyLacrimal drainage systemMedian survivalPeriorbital swellingSurgical debulkingClinical courseMean agePoor prognosisOcular adnexaCase reportTumor locationVision lossPoor survivalEarly diagnosisLacrimal glandOcular structuresPubMed database
2022
Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders
Darbinian N, Darbinyan A, Sinard J, Tatevosian G, Merabova N, D’Amico F, Khader T, Bajwa A, Martirosyan D, Gawlinski A, Pursnani R, Zhao H, Amini S, Morrison M, Goetzl L, Selzer M. Molecular Markers in Maternal Blood Exosomes Allow Early Detection of Fetal Alcohol Spectrum Disorders. International Journal Of Molecular Sciences 2022, 24: 135. PMID: 36613580, PMCID: PMC9820501, DOI: 10.3390/ijms24010135.Peer-Reviewed Original ResearchConceptsCaspase-3 activityBrain-derived exosomesMarker of synaptogenesisBrain caspase-3 activityFetal alcohol spectrum disordersMaternal blood samplesPrenatal alcohol exposureHuman fetal brainAlcohol spectrum disordersAvailable imaging techniquesMyelin basic proteinEtOH intakeEtOH exposureEtOH useMaternal raceNeurobehavioral deficitsAlcohol exposureMaternal bloodMother's bloodEarly diagnosisFetal brainBlood samplesMBP levelsTherapeutic interventionsBrain sizePrimary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa)
Zhang L, Lubin D, Sinard JH, Dickson BC, Antonescu CR, Wu H, Panni RZ, Dogan S, Untch BR, Ghossein RA, Xu B. Primary Mesenchymal Tumors of the Thyroid Gland: A Modern Retrospective Cohort Including the First Case of TFE3-Translocated Malignant Perivascular Epithelioid Cell Tumor (PEComa). Head And Neck Pathology 2022, 16: 716-727. PMID: 35218514, PMCID: PMC9424363, DOI: 10.1007/s12105-022-01428-7.Peer-Reviewed Original ResearchConceptsMalignant perivascular epithelioid cell tumorPerivascular epithelioid cell tumorEpithelioid cell tumorPrimary mesenchymal tumorsMesenchymal tumorsThyroid glandCell tumorsPeripheral nerve sheath tumorsNerve sheath tumorsSmall case seriesBiphasic synovial sarcomaOnly case reportsSolitary fibrous tumorAnaplastic thyroid carcinomaMulti-centric cohortFirst caseRetrospective cohortEpithelioid hemangioendotheliomaSheath tumorsTertiary centerCase seriesClinicopathologic featuresFemale patientsSynovial sarcomaCase report
2019
A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma
Baine MK, Sinard JH, Cai G, Homer RJ. A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma. American Journal Of Clinical Pathology 2019, 153: 165-174. PMID: 31593583, PMCID: PMC7571487, DOI: 10.1093/ajcp/aqz149.Peer-Reviewed Original ResearchImmune Checkpoint Inhibitor–Associated Pericarditis
Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL. Immune Checkpoint Inhibitor–Associated Pericarditis. Journal Of Thoracic Oncology 2019, 14: 1102-1108. PMID: 30851443, PMCID: PMC6617516, DOI: 10.1016/j.jtho.2019.02.026.Peer-Reviewed Original ResearchConceptsAdverse eventsCTLA-4 inhibitorsImmune checkpoint inhibitorsDeath-1/Pericardial window procedureCheckpoint inhibitorsThird patientClinical presentationCardiac toxicityHistopathologic findingsSide effectsPericarditisPatientsDeath ligandsPotential mechanismsWindow procedureInhibitorsImmunotherapyNSCLCCardiotoxicityAutopsiesTherapy
2018
Pleomorphic lipoma of the bulbar conjunctiva
Li E, Silbert J, Sinard J. Pleomorphic lipoma of the bulbar conjunctiva. BMJ Case Reports 2018, 11: e226548. PMID: 30567236, PMCID: PMC6301450, DOI: 10.1136/bcr-2018-226548.Peer-Reviewed Original ResearchEpithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation
Li E, Distefano A, Sinard J, Wong A, Pointdujour-Lim R. Epithelial–Myoepithelial Carcinoma Presenting as a Pseudo Veno-Lymphatic Malformation. Ophthalmic Plastic And Reconstructive Surgery 2018, 34: e157-e160. PMID: 30080758, DOI: 10.1097/iop.0000000000001179.Peer-Reviewed Original ResearchConceptsVeno-lymphatic malformationEpithelial-myoepithelial carcinomaRight eye painAdjuvant radiation therapyComplete surgical excisionFluid-fluid levelsIntralesional cystsEye painCarcinoma presentingSurgical excisionFinal diagnosisHistopathologic evaluationRadiologic workupRare neoplasmCystic spacesRadiation therapySalivary glandsPainCarcinomaMalformationsPresentingNeoplasmsHistopathologyTherapyWorkupOptimal Intraoperative Assessment of Gastric Margins
Celli R, Barbieri AL, Colunga M, Sinard J, Gibson JA. Optimal Intraoperative Assessment of Gastric Margins. American Journal Of Clinical Pathology 2018, 150: 353-363. PMID: 30020407, DOI: 10.1093/ajcp/aqy062.Peer-Reviewed Original ResearchConceptsIntraoperative pathology consultationGastric marginPositive marginsTumor distanceMajority of casesRepresentative sectionsR0 resectionConsecutive patientsGastroesophageal junctionTumor sizeNegative marginsPatient outcomesIntraoperative assessmentPathology consultationPatientsStrong associationMargin assessment
2017
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma
Tainsh LT, Coady PA, Sinard JH, Neparidze N, Meskin SW, Adelman RA, Chow J. Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma. Cornea 2017, 36: 372-374. PMID: 28079685, DOI: 10.1097/ico.0000000000001139.Peer-Reviewed Original ResearchConceptsMultiple myelomaVisual acuityRight eye 2 yearsDeep stromal opacitiesEye 2 yearsPatient's visual acuityDiagnosis of IgGParaproteinemic keratopathyInitial presentationStromal lesionsStromal opacityCase reportHematologic workupMonoclonal gammopathyAsymmetric presentationUnusual casePosterior stromaMyelomaKeratopathyPatientsDiagnosisPresentationLiterature reviewKeratoplastyAcuity
2016
Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid
Gaudio PA, Sinard J, Shield DR, Huang JJ, King BA. Repeat Conjunctival Biopsy after Immunomodulatory Therapy for Ocular Mucous Membrane Pemphigoid. Ocular Immunology And Inflammation 2016, 26: 70-73. PMID: 27437791, DOI: 10.1080/09273948.2016.1194435.Peer-Reviewed Original ResearchConceptsImmunomodulatory therapyConjunctival biopsyAntibody depositionOcular mucous membrane pemphigoidPost-treatment biopsiesMucous membrane pemphigoidEfficacy of therapyConjunctival basement membraneInactive diseaseBiopsy findingsChronic diseasesBiopsyPatient biopsiesPatientsTherapyBasement membraneDiseaseImmunofluorescence microscopyMMPsPemphigoidYearsFindings
2014
In Response: It's All About What is Typical
Sinard JH. In Response: It's All About What is Typical. Archives Of Pathology & Laboratory Medicine 2014, 138: 869-70. PMID: 24491222, DOI: 10.5858/arpa.2013-0427-edi.Peer-Reviewed Original Research
2013
Individual and geographic disparities in human papillomavirus types 16/18 in high‐grade cervical lesions
Niccolai LM, Russ C, Julian PJ, Hariri S, Sinard J, Meek JI, McBride V, Markowitz LE, Unger ER, Hadler JL, Sosa LE. Individual and geographic disparities in human papillomavirus types 16/18 in high‐grade cervical lesions. Cancer 2013, 119: 3052-3058. PMID: 23661284, DOI: 10.1002/cncr.28038.Peer-Reviewed Original Research
2002
Glandular patterns in a thyroid carcinoma with insular and anaplastic features: A case with possible implications for the classification of thyroid carcinomas
Fadare O, Sinard J. Glandular patterns in a thyroid carcinoma with insular and anaplastic features: A case with possible implications for the classification of thyroid carcinomas. Annals Of Diagnostic Pathology 2002, 6: 389-398. PMID: 12478492, DOI: 10.1053/adpa.2002.37012.Peer-Reviewed Original ResearchClonal analysis of cutaneous fibrous histiocytoma (dermatofibroma)
Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). Journal Of Cutaneous Pathology 2002, 29: 385-389. PMID: 12139632, DOI: 10.1034/j.1600-0560.2002.290701.x.Peer-Reviewed Original ResearchConceptsCutaneous fibrous histiocytomaDermatofibrosarcoma protuberansFibrous histiocytomaAR allelesCommon benign fibrohistiocytic lesionBenign fibrohistiocytic lesionsReactive fibroblastic proliferationCell typesCases of dermatofibromaAndrogen receptor geneMixed cell typeNeoplastic cell typesHistiocytoid featuresDeep fibrous histiocytomaFemale patientsHistological typeFibrohistiocytic lesionsHistiocytoid cellsInflammatory process
2001
Factors Affecting Autopsy Rates, Autopsy Request Rates, and Autopsy Findings at a Large Academic Medical Center
Sinard J. Factors Affecting Autopsy Rates, Autopsy Request Rates, and Autopsy Findings at a Large Academic Medical Center. Experimental And Molecular Pathology 2001, 70: 333-343. PMID: 11418012, DOI: 10.1006/exmp.2001.2371.Peer-Reviewed Original ResearchConceptsAcademic medical centerEmergency departmentAutopsy rateFetal deathPediatric deathsMedical CenterLarge academic medical centerGeneral surgery serviceEmergency department deathsMajor academic medical centerPercentage of casesSignificant unexpected findingsHospital deathAdult patientsPatient ageSurgery serviceAutopsy findingsPatient deathAutopsy examinationClinical assessmentCardiothoracic surgeryMedicine servicePatientsDeathGreater increase
1998
Albumin gene expression in adenocarcinomas with hepatoid differentiation
Foschini MP, Baccarini P, Dal Monte P, Sinard J, Eusebi V, Rosai J. Albumin gene expression in adenocarcinomas with hepatoid differentiation. Virchows Archiv 1998, 433: 537-541. PMID: 9870687, DOI: 10.1007/s004280050286.Peer-Reviewed Original ResearchConceptsAlpha-fetoproteinHepatoid areasHepatocellular differentiationCase 2Case 1Hepatoid adenocarcinomaHuman albumin mRNAHepatoid differentiationGastric antrumAlbumin mRNAHepatoid cellsImmunohistochemical profileUrinary bladderHepatocellular carcinomaAdenocarcinomatous areasAlbumin gene expressionProminent nucleoliOccasional cellsOval nucleiAdenocarcinomaTumor cellsPolygonal cellsSitu hybridization techniqueCEA antibodyTumors
1997
Metastatic Liposarcoma to the Orbit
Fezza J, Sinard J. Metastatic Liposarcoma to the Orbit. American Journal Of Ophthalmology 1997, 123: 271-272. PMID: 9186144, DOI: 10.1016/s0002-9394(14)71055-4.Peer-Reviewed Original ResearchConceptsVisual acuityHistory of liposarcomaPatient's visual acuityRare orbital tumorIntravenous corticosteroidsOrbital liposarcomaMetastatic liposarcomaOrbital biopsyBlurred visionDedifferentiated liposarcomaOrbital tumorsLiposarcomaHigh gradeProptosisPatientsCorticosteroidsBiopsyAcuityRecurrenceMalignancyTumorsAbdomenPhysiciansPathology
1995
Reduced alpha-catenin and E-cadherin expression in breast cancer.
Rimm DL, Sinard JH, Morrow JS. Reduced alpha-catenin and E-cadherin expression in breast cancer. Laboratory Investigation 1995, 72: 506-12. PMID: 7745946.Peer-Reviewed Original ResearchConceptsE-cadherinSteady-state levelsE-cadherin expressionHomotypic cell adhesion proteinMetastatic diseaseCell adhesion proteinsHuman E-cadherinCell-cell interactionsCytoplasmic proteinsTime of biopsyAdhesion proteinsAggressive tumor behaviorAdhesive functionEffector elementsAdhesion cascadeAbsent E-cadherin expressionTypes of cancerJunctional complexesProteinBreast cancerEpithelial tumorsSensitive markerTumor behaviorExpressionCancer
1994
Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type
Sinard J, Macleay L, Melamed J. Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer 1994, 73: 1919-1925. PMID: 7511041, DOI: 10.1002/1097-0142(19940401)73:7<1919::aid-cncr2820730724>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsHepatoid adenocarcinomaHepatocellular differentiationAlpha-fetoproteinHepatoid tumorsUrinary bladderGerm cell tumorsAnterior bladder wallUnusual histologic featuresIntracytoplasmic hyaline globulesHepatoid areasClinicopathologic featuresHistologic featuresBladder tumorsBile productionCell tumorsHepatoid cellsImmunohistochemical criteriaBladder wallGlandular patternTumor massUnusual neoplasmCarcinoembryonic antigenHyaline globulesTumor typesAdenocarcinomaCardiogenic Shock Due to Progression of Cutaneous T-Cell Lymphoma
COOPER D, SINARD J, EDELSON R, FLYNN S. Cardiogenic Shock Due to Progression of Cutaneous T-Cell Lymphoma. Southern Medical Journal 1994, 87: 89-94. PMID: 8284728, DOI: 10.1097/00007611-199401000-00021.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaCardiac involvementProgressive cutaneous T-cell lymphomaCardiogenic shockClinical suspicionHematogenous spreadEndomyocardial biopsyCardiac failureLymphomatous involvementCardiac enlargementConduction disturbancesSingle symptomTumor cellsPatientsLymphomaReasonable chanceInvolvementEchocardiographyChemotherapyTachyarrhythmiasBiopsySymptomsMyocardiumSuspicion