2003
Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects
Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Preliminary evidence of hippocampal dysfunction in adolescent MDMA (“ecstasy”) users: possible relationship to neurotoxic effects. Psychopharmacology 2003, 173: 383-390. PMID: 14647960, DOI: 10.1007/s00213-003-1679-4.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMDMA usersCognitive deficitsMDMA useBrain functionDivided attentionMemory taskMemory loadResultsMDMA usersLeft hippocampusHippocampal dysfunctionSubstance useCognitive impairmentAdolescencePreliminary evidenceReaction timeDevelopmental impactPilot sampleDeficitsMDMAMagnetic resonance imagingIQAttentionMemoryHippocampus
1997
The role of serotonin in the pathophysiology and treatment of schizophrenia
Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. Journal Of Neuropsychiatry 1997, 9: 1-17. PMID: 9017523, DOI: 10.1176/jnp.9.1.1.Peer-Reviewed Original ResearchConceptsRole of serotoninBeneficial effectsSubcortical dopamine activityCerebrospinal fluid studiesCortex of patientsTreatment of schizophreniaBrain tissue analysisSerotonergic hypofunctionDopaminergic antagonistsPharmacological challengeDopamine activityNegative symptomsFluid studiesSchizophreniaPathophysiologySerotoninIllnessTissue analysisTreatmentMore researchAntagonismCompelling evidenceHypofunctionPatientsAntagonist