2023
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteria
2005
Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta
Koullias G, Modak R, Tranquilli M, Korkolis DP, Barash P, Elefteriades JA. Mechanical deterioration underlies malignant behavior of aneurysmal human ascending aorta. Journal Of Thoracic And Cardiovascular Surgery 2005, 130: 677.e1-677.e9. PMID: 16153912, DOI: 10.1016/j.jtcvs.2005.02.052.Peer-Reviewed Original ResearchConceptsMechanical characteristicsMechanical deteriorationHuman ascending aortaAortic aneurysmAortic wall stressNormal aortaAneurysmal aortaAortic distensibilityAscending aortaMalignant behaviorAortic wallWall stressMaximal tensile strengthMechanical propertiesCoronary artery bypassTensile strengthTime of surgeryAortic wall thicknessAscending Aortic AneurysmMalignant clinical behaviorElastic modulusHuman ascending aortic aneurysmsEngineering analysisAneurysmal aortic wallMechanical substrate
1999
PATHOLOGIC VARIANTS OF THORACIC AORTIC DISSECTIONS Penetrating Atherosclerotic Ulcers and Intramural Hematomas
Coady M, Rizzo J, Elefteriades J. PATHOLOGIC VARIANTS OF THORACIC AORTIC DISSECTIONS Penetrating Atherosclerotic Ulcers and Intramural Hematomas. Cardiology Clinics 1999, 17: 637-657. PMID: 10589337, DOI: 10.1016/s0733-8651(05)70106-5.Peer-Reviewed Original ResearchConceptsClassic aortic dissectionAcute aortic pathologyIntramural hematomaAortic dissectionAortic lumenAtherosclerotic ulcerAortic lesionsIMH patientsAortic pathologyClassic dissectionRupture rateType B aortic dissectionTypical aortic dissectionB aortic dissectionDistinct clinical entityThoracic aortic dissectionTypical patient profileMore superficial locationHigher rupture rateBranch-vessel compromiseLarger aortasMinimal arteriosclerosisTypical dissectionIschemic manifestationsThoracoabdominal aortaINTERPRETING DATA ON THORACIC AORTIC ANEURYSMS Statistical Issues
Rizzo J, Coady M, Elefteriades J. INTERPRETING DATA ON THORACIC AORTIC ANEURYSMS Statistical Issues. Cardiology Clinics 1999, 17: 797-805. PMID: 10589346, DOI: 10.1016/s0733-8651(05)70115-6.Peer-Reviewed Original ResearchSurgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications
Coady M, Rizzo J, Hammond G, Kopf G, Elefteriades J. Surgical intervention criteria for thoracic aortic aneurysms: a study of growth rates and complications. The Annals Of Thoracic Surgery 1999, 67: 1922-1926. PMID: 10391339, DOI: 10.1016/s0003-4975(99)00431-2.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmDevastating complicationAortic growth rateComplications of ruptureIncidence of dissectionTime of complicationsRisk of dissectionMultivariable regression analysisMedian sizeSurgical intervention criteriaTime of dissectionAcute dissectionElective resectionPerioperative complicationsInitial presentationSurgical interventionRisk factorsThoracic aortaAneurysm sizeComplicationsTime of ruptureYale University SchoolLower mortalityAneurysms
1998
Penetrating ulcer of the thoracic aorta: What is it? How do we recognize it? How do we manage it?
Coady M, Rizzo J, Hammond G, Pierce J, Kopf G, Elefteriades J. Penetrating ulcer of the thoracic aorta: What is it? How do we recognize it? How do we manage it? Journal Of Vascular Surgery 1998, 27: 1006-1016. PMID: 9652462, DOI: 10.1016/s0741-5214(98)70003-5.Peer-Reviewed Original ResearchConceptsAortic dissectionOptimal treatmentThoracic aortaNatural historyType AType B aortic dissectionB aortic dissectionClassic aortic dissectionLarger aortic diametersAortic ulcerAtherosclerotic ulcerAortic ruptureClinical featuresInitial diagnosisInitial presentationIntraoperative findingsRetrospective reviewSurgical managementAortic diameterRadiologic signsTomographic scanPathology reportsUlcersPatientsAorta
1997
What is the appropriate size criterion for resection of thoracic aortic aneurysms?
Coady M, Rizzo J, Hammond G, Mandapati D, Darr U, Kopf G, Elefteriades J. What is the appropriate size criterion for resection of thoracic aortic aneurysms? Journal Of Thoracic And Cardiovascular Surgery 1997, 113: 476-491. PMID: 9081092, DOI: 10.1016/s0022-5223(97)70360-x.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmAortic aneurysmIncidence of dissectionTime of complicationsMultivariable regression analysisMedian sizeAppropriate size criterionTime of dissectionAcute dissectionElective resectionPerioperative complicationsDevastating complicationOverall survivalAortic dissectionInitial presentationElective operationsSurgical interventionRisk factorsThoracic aortaAneurysm sizeTime of rupturePatientsYale University SchoolAneurysmsLower mortality
1992
Long-term experience with descending aortic dissection: The complication-specific approach
Elefteriades J, Hartleroad J, Gusberg R, Salazar A, Black H, Kopf G, Baldwin J, Hammond G. Long-term experience with descending aortic dissection: The complication-specific approach. The Annals Of Thoracic Surgery 1992, 53: 11-21. PMID: 1728218, DOI: 10.1016/0003-4975(92)90752-p.Peer-Reviewed Original ResearchConceptsComplication-specific approachAortic dissectionActuarial survivalGraft replacementComplications of dissectionLower intercostal arteriesLeft subclavian arteryLong-term resultsUncomplicated dissectionLimb ischemiaPostoperative studiesSubclavian arteryFalse lumenSurgical managementIntercostal arteriesRadiographic findingsComplicated dissectionFenestration procedurePatientsSaccular aneurysmLong-term experienceAortaWhole groupDissectionFenestration