2013
COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers
Herman AI, Jatlow PI, Gelernter J, Listman JB, Sofuoglu M. COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers. The Pharmacogenomics Journal 2013, 13: 490-497. PMID: 23459442, PMCID: PMC3675163, DOI: 10.1038/tpj.2013.1.Peer-Reviewed Original ResearchConceptsVal/Val genotypeAbstinent smokersVal genotypeGreater systolic blood pressureOvernight abstinent smokersVal158Met polymorphismSystolic blood pressureDoses of nicotineCatechol-O-methyltransferase (COMT) Val158Met polymorphismVal/ValEuropean American smokersNegative subjective effectsCOMT Val158Met polymorphismBlood pressureSmoking cessationAA smokersRisk factorsAmerican smokersIntravenous nicotineWithdrawal severityOvernight abstinenceSmokersNicotine addictionNicotine useSubjective effects
2012
The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex
Amstadter AB, MacPherson L, Wang F, Banducci AN, Reynolds EK, Potenza MN, Gelernter J, Lejuez CW. The relationship between risk-taking propensity and the COMT Val158Met polymorphism among early adolescents as a function of sex. Journal Of Psychiatric Research 2012, 46: 940-945. PMID: 22575334, PMCID: PMC3687344, DOI: 10.1016/j.jpsychires.2012.04.010.Peer-Reviewed Original Research
2006
Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children
Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-Derived Neurotrophic Factor–5-HTTLPR Gene Interactions and Environmental Modifiers of Depression in Children. Biological Psychiatry 2006, 59: 673-680. PMID: 16458264, DOI: 10.1016/j.biopsych.2005.10.026.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrain-Derived Neurotrophic FactorCase-Control StudiesChildChild AbuseChild, PreschoolChi-Square DistributionDepressionDNA Mutational AnalysisEnvironmentFemaleGene FrequencyGenetic VariationGenotypeHumansMaleMethioninePredictive Value of TestsPsychiatric Status Rating ScalesRisk FactorsSerotonin Plasma Membrane Transport ProteinsSeverity of Illness IndexSocial SupportSurveys and QuestionnairesValineConceptsBrain-derived neurotrophic factor (BDNF) genotypeNeurotrophic factor genotypeSocial supportHigher depression scoresBDNF genotypeProportion scoreBDNF geneProtective effectDepression scoresComparison subjectsPsychiatric symptomatologyModerate riskEnvironmental modifiersDepressionFactor genotypeChildrenDNA specimensStandard research instrumentsShort alleleRiskMaltreatment historyCurrent dataScoresAncestry informative markersChild abuse
2005
COMT Polymorphisms and Anxiety-Related Personality Traits
Stein MB, Fallin MD, Schork NJ, Gelernter J. COMT Polymorphisms and Anxiety-Related Personality Traits. Neuropsychopharmacology 2005, 30: 2092-2102. PMID: 15956988, DOI: 10.1038/sj.npp.1300787.Peer-Reviewed Original ResearchAdolescentAdultAnxietyCatechol O-MethyltransferaseChi-Square DistributionConfidence IntervalsDemographyExtraversion, PsychologicalFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleMethionineNeurotic DisordersOdds RatioPersonalityPersonality InventoryPolymorphism, GeneticSex FactorsValine