2017
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms
Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D, Consortium C, Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PAF, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M, Consortium T, Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol‐Response Behaviors in Model Organisms. Alcohol Clinical And Experimental Research 2017, 41: 911-928. PMID: 28226201, PMCID: PMC5404949, DOI: 10.1111/acer.13362.Peer-Reviewed Original ResearchConceptsModel organismsGenomewide association studiesLoss of functionAssociation studiesPrimate-specific genesAcute functional toleranceOrthologous genesCaenorhabditis elegansSuggestive signalsOrthologsExpression differencesGene expressionCOL6A3 expressionGenesAlcohol dependenceNucleus accumbensKLF12 expressionSuggestive associationElegansCOL6A3AD liabilityPotential involvementMultiple brain functionsEtOH sensitivityKLF12
2011
ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure
Chen J, Brunzell DH, Jackson K, van der Vaart A, Z. J, Payne TJ, Sherva R, Farrer LA, Gejman P, Levinson DF, Holmans P, Aggen SH, Damaj I, Kuo PH, Webb BT, Anton R, Kranzler HR, Gelernter J, Li MD, Kendler KS, Chen X. ACSL6 Is Associated with the Number of Cigarettes Smoked and Its Expression Is Altered by Chronic Nicotine Exposure. PLOS ONE 2011, 6: e28790. PMID: 22205969, PMCID: PMC3243669, DOI: 10.1371/journal.pone.0028790.Peer-Reviewed Original ResearchConceptsACSL6 geneNicotine exposureNicotinic receptor antagonist mecamylaminePrevious schizophrenia studiesChronic nicotine exposureNicotinic receptor activationHippocampus of miceNumber of cigarettesOsmotic mini pumpsQuantity of cigarettesNon-schizophrenic subjectsAssociation of schizophreniaCigarettes SmokedHeavy smokersTobacco smokingNicotine administrationAntagonist mecamylamineControl subjectsIndependent associationTobacco dependenceFTND scoreHigh riskMini pumpsChronic exposureReceptor activation
2008
Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon Growth
Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM. Genetic Variants of Nogo-66 Receptor with Possible Association to Schizophrenia Block Myelin Inhibition of Axon Growth. Journal Of Neuroscience 2008, 28: 13161-13172. PMID: 19052207, PMCID: PMC2892845, DOI: 10.1523/jneurosci.3828-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainChick EmbryoChlorocebus aethiopsChromosome MappingCodonCOS CellsFemaleGenetic Predisposition to DiseaseGPI-Linked ProteinsGrowth ConesGrowth InhibitorsHumansMaleMiceMice, KnockoutMutationMyelin ProteinsNerve Fibers, MyelinatedNeurogenesisNeuronal PlasticityNogo Receptor 1Organ Culture TechniquesRatsReceptors, Cell SurfaceSchizophreniaConceptsMyelin inhibitionNogo-66 receptorCase-control analysisMyelin-specific genesAxonal sproutingMyelin signalGenetic predispositionAxon inhibitionNeuronal culturesPossible associationReceptor 1Disease riskAxon growthSchizophreniaAxonal proteinsPotential endophenotypeMemory functionGenetic variantsDysfunctional proteinsInhibitionSchizophrenia susceptibilityDominant negativeProtein exhibitCandidate genesChromosome 22q11Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens
Potenza MN, Brodkin ES, Yang BZ, Birnbaum SG, Nestler EJ, Gelernter J. Quantitative Trait Locus Analysis Identifies Rat Genomic Regions Related to Amphetamine-Induced Locomotion and Gαi3 Levels in Nucleus Accumbens. Neuropsychopharmacology 2008, 33: 2735-2746. PMID: 18216777, PMCID: PMC2818767, DOI: 10.1038/sj.npp.1301667.Peer-Reviewed Original ResearchConceptsQuantitative trait lociRobust quantitative trait lociGenomic regionsChromosome 2Quantitative trait locus (QTL) analysisG protein levelsCommon genetic mechanismQTL patternsTrait lociRat genomic regionsGenetic mechanismsChromosome 3Locus analysisChromosome 13Genetic factorsGαi3LociAmphetamine-Induced LocomotionBetter understandingLocomotionRegionAnimal modelsSignificant implicationsLevelsNovelty-induced locomotion
2004
Genomic regions controlling corticosterone levels in rats
Potenza MN, Brodkin ES, Joe B, Luo X, Remmers EF, Wilder RL, Nestler EJ, Gelernter J. Genomic regions controlling corticosterone levels in rats. Biological Psychiatry 2004, 55: 634-641. PMID: 15013833, DOI: 10.1016/j.biopsych.2003.11.005.Peer-Reviewed Original ResearchConceptsGenomic regionsQuantitative trait locus (QTL) analysisGenome-wide levelSpecific genomic regionsUnderstanding of susceptibilitySignificant QTLGenomic backgroundChromosome 4Locus analysisF2 progenyGenetic differencesSuggestive significanceDisease susceptibilityQTLFirst identificationCongenic animalsDeoxyribonucleic acidGenetic factorsProgenyIdentificationRegionSusceptibilityLevels
1990
Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
Sunahara R, Niznik H, Weiner D, Stormann T, Brann M, Kennedy J, Gelernter J, Rozmahel R, Yang Y, Israel Y, Seeman P, O'Dowd B. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature 1990, 347: 80-83. PMID: 1975640, DOI: 10.1038/347080a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBenzazepinesBrain ChemistryCattleChromosomes, Human, Pair 5Cloning, MolecularGlycosylationHumansIntronsMaleMolecular Sequence DataNucleic Acid HybridizationPhosphorylationPolymorphism, Restriction Fragment LengthRatsRats, Inbred StrainsReceptors, DopamineReceptors, Dopamine D1Restriction MappingRNA, MessengerTissue DistributionTransfectionConceptsD1 receptorsD2 receptorsChromosome 5Adenylyl cyclaseCyclic AMP-dependent proteinHuman dopamine D1 receptorDopamine D1 receptorsHuman D1 receptorD1 receptor geneFamily of receptorsDrug therapyDopamine D1Dopamine D2Intronless genesParkinson's diseasePsychomotor disordersRestriction fragment length polymorphismFragment length polymorphismReceptorsFunctional typesReceptor familyDrug addictionReceptor geneAmino acidsLong arm