2009
Adolescent cannabis use increases risk for cocaine-induced paranoia
Kalayasiri R, Gelernter J, Farrer L, Weiss R, Brady K, Gueorguieva R, Kranzler HR, Malison RT. Adolescent cannabis use increases risk for cocaine-induced paranoia. Drug And Alcohol Dependence 2009, 107: 196-201. PMID: 19944543, PMCID: PMC2821949, DOI: 10.1016/j.drugalcdep.2009.10.006.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAge FactorsAge of OnsetCannabisCatechol O-MethyltransferaseCocaine-Related DisordersFemaleGene FrequencyGenetic Predisposition to DiseaseHumansLogistic ModelsMaleParanoid DisordersPolymerase Chain ReactionPrevalencePsychiatric Status Rating ScalesRisk FactorsSeverity of Illness IndexSiblingsUnited StatesConceptsAdolescent onset cannabisEarly cannabis exposureCocaine-dependent individualsCocaine-induced paranoiaCannabis exposureRisk factorsCOMT genotypeSemi-Structured AssessmentCatechol-O-methyl transferase (COMT) geneCOMT Val158Met genotypeCannabis abuseIncrease riskPsychotic symptomsOnset interactionPsychotic disordersStimulant abuseDrug dependenceFamily-based studyLogistic regressionEarly exposureAdolescent cannabisCannabisGenetic factorsSignificant predictorsVal158Met genotypeBDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study
Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF Variants, Premorbid Educational Attainment, and Disease Characteristics in Alzheimer's Disease: An Exploratory Study. Journal Of Alzheimer's Disease 2009, 17: 887-898. PMID: 19542613, PMCID: PMC4084650, DOI: 10.3233/jad-2009-1106.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAllelesAlzheimer DiseaseBrain-Derived Neurotrophic FactorCognitionDisease ProgressionEducational StatusFemaleGene FrequencyGenetic Predisposition to DiseaseHallucinationsHumansMalePolymerase Chain ReactionPolymorphism, Single NucleotidePrevalenceRetrospective StudiesSeverity of Illness IndexConceptsBrain-derived neurotrophic factorNeuropsychiatric symptomsAlzheimer's diseaseBDNF polymorphismFunctional declineRole of BDNFMultiple subsequent time pointsVal/Val groupBDNF genetic variantsC270T polymorphismPresence of hallucinationsMet/MetSubsequent time pointsVal/MetBDNF variantsClinical courseVal66Met genotypeVal66Met polymorphismC270TDisease characteristicsNeurotrophic factorTests of cognitionNeuronal survivalAD patientsHigh prevalence
2004
NOTCH4 gene haplotype is associated with schizophrenia in African Americans
Luo X, Klempan TA, Lappalainen J, Rosenheck RA, Charney DS, Erdos J, van Kammen DP, Kranzler HR, Kennedy JL, Gelernter J. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Biological Psychiatry 2004, 55: 112-117. PMID: 14732589, DOI: 10.1016/s0006-3223(03)00588-2.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanChi-Square DistributionCysteineDiagnostic and Statistical Manual of Mental DisordersFemaleGene FrequencyGenotypeGlycineHaplotypesHumansLinkage DisequilibriumMalePolymerase Chain ReactionPolymorphism, Single NucleotideProto-Oncogene ProteinsReceptor, Notch4Receptors, Cell SurfaceReceptors, NotchSchizophreniaThreonineConceptsHealthy control subjectsControl subjectsSingle nucleotide polymorphismsExact testSchizophrenia patientsAfrican AmericansFisher's exact testNOTCH4 locusChi-square testComparison of alleleEuropean-American subjectsPositive linkage disequilibriumAA subjectsPatientsSchizophreniaSpecific markersHaplotype frequenciesT associatesLinkage disequilibriumEA subjectsNOTCH4 geneSubjectsGene haplotypesAmerican subjectsNucleotide polymorphisms
2003
Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics
Nellissery M, Feinn RS, Covault J, Gelernter J, Anton RF, Pettinati H, Moak D, Mueller T, Kranzler HR. Alleles of a Functional Serotonin Transporter Promoter Polymorphism Are Associated With Major Depression in Alcoholics. Alcohol Clinical And Experimental Research 2003, 27: 1402-1408. PMID: 14506400, DOI: 10.1097/01.alc.0000085588.11073.bb.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAllelesBlack PeopleCarrier ProteinsChromosome MappingComorbidityDepressive Disorder, MajorFemaleGene FrequencyGenotypeHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPhenotypePolymerase Chain ReactionPolymorphism, GeneticPromoter Regions, GeneticSerotonin Plasma Membrane Transport ProteinsWhite PeopleConceptsMajor depressionComorbid alcohol dependenceAlcohol dependenceFunctional serotonin transporter promoter polymorphismAfrican American patientsSubstance use disordersSerotonin transporter promoter polymorphismShort alleleTransporter promoter polymorphismSerotonin transporter proteinAntidepressant treatmentPatient groupAmerican patientsSerotonergic neurotransmissionDepressed alcoholicsMood disordersPromoter polymorphismUnipolar depressionUse disordersControl groupTreatment studiesFunctional polymorphismsGenetic predictorsSerotonin transporterWhole blood
2001
Suicide, impulsive aggression, and HTR1B genotype
New A, Gelernter J, Goodman M, Mitropoulou V, Koenigsberg H, Silverman J, Siever L. Suicide, impulsive aggression, and HTR1B genotype. Biological Psychiatry 2001, 50: 62-65. PMID: 11457425, DOI: 10.1016/s0006-3223(01)01108-8.Peer-Reviewed Original ResearchAdultAggressionCell Cycle ProteinsChromosomes, Human, Pair 6Disruptive, Impulse Control, and Conduct DisordersFemaleFungal ProteinsGenetic Predisposition to DiseaseGenotypeHumansMalePersonality DisordersPolymerase Chain ReactionPolymorphism, GeneticRepressor ProteinsRNA-Binding ProteinsSaccharomyces cerevisiae ProteinsSuicide, Attempted
2000
Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report
Jacobsen LK, Staley JK, Zoghbi SS, Seibyl JP, Kosten TR, Innis RB, Gelernter J. Prediction of Dopamine Transporter Binding Availability by Genotype: A Preliminary Report. American Journal Of Psychiatry 2000, 157: 1700-1703. PMID: 11007732, DOI: 10.1176/appi.ajp.157.10.1700.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarrier ProteinsDNADopamineDopamine Plasma Membrane Transport ProteinsFemaleGenotypeHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMinisatellite RepeatsNerve Tissue ProteinsPolymerase Chain ReactionPolymorphism, GeneticSerotonin Plasma Membrane Transport ProteinsTomography, Emission-Computed, Single-Photon
1999
Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects
Gelernter J, Kranzler H, Cubells J. Genetics of two μ opioid receptor gene (OPRM1) exon I polymorphisms: population studies, and allele frequencies in alcohol- and drug-dependent subjects. Molecular Psychiatry 1999, 4: 476-483. PMID: 10523821, DOI: 10.1038/sj.mp.4000556.Peer-Reviewed Original Research
1997
Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH)
Cubells J, Kobayashi K, Nagatsu T, Kidd K, Kidd J, Calafell F, Kranzler H, Ichinose H, Gelernter J. Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH). American Journal Of Medical Genetics 1997, 74: 374-379. PMID: 9259372, DOI: 10.1002/(sici)1096-8628(19970725)74:4<374::aid-ajmg7>3.0.co;2-p.Peer-Reviewed Original Research
1994
Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia
Gelernter J, Kranzler H, Satel S, Rao P. Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia. Neuropsychopharmacology 1994, 11: 195-200. PMID: 7865100, DOI: 10.1038/sj.npp.1380106.Peer-Reviewed Original ResearchPstl RFLP at the SERT locus
Gelernter J, Freimer M. Pstl RFLP at the SERT locus. Human Molecular Genetics 1994, 3: 383-383. PMID: 7911700, DOI: 10.1093/hmg/3.2.383.Peer-Reviewed Original ResearchBase SequenceCarrier ProteinsChromosomes, Human, Pair 17Deoxyribonucleases, Type II Site-SpecificDNA PrimersGenesHumansMembrane GlycoproteinsMembrane Transport ProteinsMolecular Sequence DataNerve Tissue ProteinsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthSerotonin Plasma Membrane Transport ProteinsNo structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis.
Gejman PV, Ram A, Gelernter J, Friedman E, Cao Q, Pickar D, Blum K, Noble EP, Kranzler HR, O'Malley S. No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. JAMA 1994, 271: 204-8. PMID: 8277546, DOI: 10.1001/jama.271.3.204.Peer-Reviewed Original Research
1993
Eliminating mitochondrial DNA competition for nuclear DNA primers.
Zullo S, Kennedy JL, Gelernter J, Polymeropoulos MH, Tallini G, Pakstis AJ, Shapiro MB, Merril CR, Kidd KK. Eliminating mitochondrial DNA competition for nuclear DNA primers. Genome Research 1993, 3: 39-45. PMID: 7693114, DOI: 10.1101/gr.3.1.39.Peer-Reviewed Original Research
1991
Sequence tagged site (STS) Taql RFLP at dopamine β-hydroxylase (DBH)
Gelernter J, Gejman PV, Bisighini S, Kidd KK. Sequence tagged site (STS) Taql RFLP at dopamine β-hydroxylase (DBH). Nucleic Acids Research 1991, 19: 1957-1957. PMID: 1674371, PMCID: PMC328142, DOI: 10.1093/nar/19.8.1957.Peer-Reviewed Original Research