2016
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene
Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology 2016, 42: 598-605. PMID: 27531626, PMCID: PMC5240175, DOI: 10.1038/npp.2016.153.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorAlcohol dependenceLow-frequency fluctuation (ALFF) analysisLeft superior frontal gyrusMultiple sexual partnersDSM-IV criteriaSexual behaviorMagnetic Resonance Imaging AnalysisAnterior cingulate regionsSuperior frontal gyrusMonetary incentive delay taskLifetime alcohol dependenceIncentive delay taskRight amygdalaClinical relevanceSTD riskUnprotected sexBrain circuitryFunctional magnetic resonance imaging (fMRI) analysisCingulate regionsSexual partnersFrequency fluctuation analysisFrontal gyrusGenetic findingsReduced activation
2007
Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA)
Pierucci-Lagha A, Gelernter J, Chan G, Arias A, Cubells JF, Farrer L, Kranzler HR. Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA). Drug And Alcohol Dependence 2007, 91: 85-90. PMID: 17590536, PMCID: PMC2039919, DOI: 10.1016/j.drugalcdep.2007.04.014.Peer-Reviewed Original ResearchConceptsDSM-IV diagnosisDSM-IV criteriaSemi-Structured AssessmentDrug dependenceIndividual DSM-IV criteriaDiagnostic reliabilityDiagnostic criteriaSubstance dependenceDSM-IV diagnostic criteriaIndividual diagnostic criteriaSubstance dependence diagnosesOpioid dependenceTest-retest reliabilityInter-rater reliabilityPsychiatric disordersDependence diagnosisCocaine dependenceConfidence intervalsDiagnosisInter-rater reliability estimatesAlcoholismSedativesCriteriaIndividual criteriaSpecific groups
2000
Family‐Based study of DRD2 alleles in alcohol and drug dependence
Blomqvist O, Gelernter J, Kranzler H. Family‐Based study of DRD2 alleles in alcohol and drug dependence. American Journal Of Medical Genetics 2000, 96: 659-664. PMID: 11054774, DOI: 10.1002/1096-8628(20001009)96:5<659::aid-ajmg12>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsCase-control studyDrug dependenceAlcohol dependenceFamily-based studySubstance dependenceRecent family-based studyNumerous case-control studiesDSM-IV criteriaDopamine D2 receptor geneDRD2 allelesPresent studyD2 receptor geneDSM-IIIVariant allelesTransmission disequilibrium testConflicting resultsReceptor geneNegative resultsPositive associationEuropean AmericansTaqI AEuropean ancestryLinkage disequilibriumDisequilibrium testSmall nuclear families