2017
Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers
Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Stein MB, Gelernter J. Trauma exposure interacts with the genetic risk of bipolar disorder in alcohol misuse of US soldiers. Acta Psychiatrica Scandinavica 2017, 137: 148-156. PMID: 29230810, PMCID: PMC6110087, DOI: 10.1111/acps.12843.Peer-Reviewed Original ResearchConceptsBD polygenic risk scorePolygenic risk scoresAlcohol misuseBipolar disorderTrauma exposurePsychiatric disordersGenetic riskMajor depressive disorderNicotine dependence symptomsSubstance use disordersSchizophrenia polygenic risk scoresVoltage-gated calcium channel activityCalcium channel activityUS Army soldiersBeta2-adrenergic receptorDepressive disorderRisk scoreUse disordersAdrenergic receptorsMental disordersSubstance abuseDisordersDependence symptomsChannel activityExposureGenetic and psychosocial predictors of alcohol use trajectories among disaster‐exposed adolescents
Bountress K, Danielson CK, Williamson V, Vladmirov V, Gelernter J, Ruggiero K, Amstadter A. Genetic and psychosocial predictors of alcohol use trajectories among disaster‐exposed adolescents. American Journal On Addictions 2017, 26: 623-631. PMID: 28594439, PMCID: PMC5627968, DOI: 10.1111/ajad.12575.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdolescent BehaviorAlcohol DrinkingDisastersFemaleGenetic Association StudiesGenome-Wide Association StudyHumansMalePsychological TechniquesRisk FactorsSocial SupportSouth CarolinaStress Disorders, Post-TraumaticStress, PsychologicalTrauma Severity IndicesConceptsDisaster-exposed adolescentsAdolescent alcohol misuseAlcohol use trajectoriesPTSD symptomsEmotional supportAlcohol misuseDisaster exposurePosttraumatic stress disorder (PTSD) symptomsAdolescent PTSD symptomsMore PTSD symptomsAlcohol useUse trajectoriesAlcohol use/misuseAlcohol use outcomesCommunity/familyUse/misuseWeb-based interventionDisorder symptomsPsychosocial predictorsSeverity of exposureUse outcomesAdolescentsGenetic riskCurrent studyLong-term adverse outcomesA genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus
Polimanti R, Kaufman J, Zhao H, Kranzler HR, Ursano RJ, Kessler RC, Gelernter J, Stein MB. A genome-wide gene-by-trauma interaction study of alcohol misuse in two independent cohorts identifies PRKG1 as a risk locus. Molecular Psychiatry 2017, 23: 154-160. PMID: 28265120, PMCID: PMC5589475, DOI: 10.1038/mp.2017.24.Peer-Reviewed Original ResearchConceptsGenome-wide interaction studyGene Ontology (GO) enrichment analysisOntology enrichment analysisProtein kinase 1Protein regulationSame effect directionCyclic GMP-dependent protein kinase 1Circadian rhythm regulationRisk lociWide geneEnrichment analysisInteraction studiesKinase 1Individual genetic riskPsychiatric geneticsCalcium-activated potassium channelsGenesLociPRKG1Potassium channelsEffect directionRhythm regulationAlcohol use problemsRegulationAlcohol misuse
2016
Alcohol Misuse and Co‐Occurring Mental Disorders Among New Soldiers in the U.S. Army
Stein MB, Campbell‐Sills L, Gelernter J, He F, Heeringa SG, Nock MK, Sampson NA, Sun X, Jain S, Kessler RC, Ursano RJ, Collaborators S. Alcohol Misuse and Co‐Occurring Mental Disorders Among New Soldiers in the U.S. Army. Alcohol Clinical And Experimental Research 2016, 41: 139-148. PMID: 27883222, PMCID: PMC5205544, DOI: 10.1111/acer.13269.Peer-Reviewed Original ResearchConceptsAlcohol use disorderBinge drinkingAlcohol misuseMental disordersHeavy drinkingAdverse outcomesAssociation of AUDSuicidal ideationProbable alcohol use disorderOnset of AUDSubstance abuse/dependencePrior alcohol use disordersPrior mental disordersLifetime alcohol use disorderStrong bidirectional associationLifetime alcohol consumptionAbuse/dependenceCohort of soldiersBasic combat trainingDiscrete-time survival analysisOverall burdenUse disordersAlcohol consumptionDrug useSurvival analysis