2024
Prospective and External Validation of an Ensemble Learning Approach to Sensitively Detect Intravenous Fluid Contamination in Basic Metabolic Panels
Spies N, Militello L, Farnsworth C, El-Khoury J, Durant T, Zaydman M. Prospective and External Validation of an Ensemble Learning Approach to Sensitively Detect Intravenous Fluid Contamination in Basic Metabolic Panels. Clinical Chemistry 2024, hvae168. PMID: 39545815, DOI: 10.1093/clinchem/hvae168.Peer-Reviewed Original ResearchSHapley Additive exPlanationsLearning approachDetection of contamination eventsUnsupervised learning approachLearning-based methodsMachine learning-based methodsEnsemble learning approachMachine learning pipelineEnsemble learningLearning pipelineMatthews correlation coefficientAlgorithmic fairnessReal worldSHapley Additive exPlanations valuesCurrent workflowsClinical workflowWorkflowOperational burdenBasic metabolic panelIntravenous (IVPipelineInternal validation setValidation setFlagging ratesPerformance assessmentLaboratory Anomalies in the Basic Metabolic Panel: Core Curriculum 2025
Takieddine L, El-Khoury J. Laboratory Anomalies in the Basic Metabolic Panel: Core Curriculum 2025. American Journal Of Kidney Diseases 2024 PMID: 39396361, DOI: 10.1053/j.ajkd.2024.06.019.Peer-Reviewed Original ResearchBreaking the Chain: Navigating the Pitfalls of Total Laboratory Automation
El-Khoury J. Breaking the Chain: Navigating the Pitfalls of Total Laboratory Automation. The Journal Of Applied Laboratory Medicine 2024, 9: 1095-1096. PMID: 39225460, DOI: 10.1093/jalm/jfae061.Peer-Reviewed Original ResearchADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins
Cao J, Donato L, El-Khoury J, Goldberg A, Meeusen J, Remaley A. ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins. The Journal Of Applied Laboratory Medicine 2024, 9: 1040-1056. PMID: 39225455, DOI: 10.1093/jalm/jfae057.Peer-Reviewed Original ResearchConceptsNon-HDL-CLDL-C calculationLDL-CLipid panelLipoprotein cholesterolMeasurement of blood lipidsNon-high-density lipoprotein cholesterolElevated concentration of triglyceridesLow-density lipoprotein cholesterolMeasured LDL-CAtherosclerotic disease riskLipid testingConcentrations of triglyceridesClinical managementDisease riskReporting of resultsBlood lipidsPre-analytical requirementsApolipoprotein BFasting requirementsImprove standardsGuidance documentsLipidCholesterolLipoproteinDirect analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting
Choucair I, Shang E, Tran M, Cassella-McLane G, El-Khoury J. Direct analysis in real time mass spectrometry (DART-MS/MS) for rapid urine opioid detection in a clinical setting. Clinica Chimica Acta 2024, 564: 119939. PMID: 39197698, DOI: 10.1016/j.cca.2024.119939.Peer-Reviewed Original ResearchDART-MS/MSMass spectrometryReal time mass spectrometryTime mass spectrometrySample preparationLC-MS/MSEfficient sample preparationTandem mass spectrometryDirect analysisLiquid chromatography-tandem mass spectrometryChromatography-tandem mass spectrometryAnalytical measurement rangeVortex timeSpectrometryOpioid drugsTurnaround timeUrine samplesOpioidClinical settingDrug testingUrineDefinitive testsNorfentanylDrugPreparationChatGPT: A Reliable Laboratory Medicine Consult?
El-Khoury J. ChatGPT: A Reliable Laboratory Medicine Consult? Clinical Chemistry 2024, 70: 1089-1091. PMID: 39045739, DOI: 10.1093/clinchem/hvae100.Peer-Reviewed Original ResearchAccounting for differences between serum and plasma: An indirect approach to derive reference intervals for total protein, albumin, and globulin
Militello L, El-Khoury J, Durant T. Accounting for differences between serum and plasma: An indirect approach to derive reference intervals for total protein, albumin, and globulin. Clinica Chimica Acta 2024, 562: 119851. PMID: 38977172, DOI: 10.1016/j.cca.2024.119851.Peer-Reviewed Original ResearchPuzzling undetectable haptoglobin in a transfused pregnant patient
Chaves Rivera M, Choucair I, Vera M, El-Khoury J, Figueroa Villalba C. Puzzling undetectable haptoglobin in a transfused pregnant patient. Clinica Chimica Acta 2024, 561: 119829. PMID: 38917868, DOI: 10.1016/j.cca.2024.119829.Peer-Reviewed Original ResearchAcute hemolytic transfusion reactionUndetectable haptoglobin levelUndetectable haptoglobinPregnant patientsHaptoglobin levelsB-cell acute lymphocytic leukemiaPregnancy-related physiological changesTrimester-specific reference intervalsReference intervalsCenters for Disease Control (CDC) criteriaDiagnosis of hemolysisNon-pregnant counterpartsTrimester of pregnancyAcute lymphocytic leukemiaHemolytic transfusion reactionsMultidisciplinary approach to patient careFollow-up visitRed cell unitsLactate dehydrogenasePhysiological changesRBC transfusionThird trimesterLymphocytic leukemiaLaboratory findingsImmunological markersTime to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals?
El-Khoury J, Badrick T, Theodorsson E. Time to Reevaluate the 95% Inclusion Criteria for Defining Reference Intervals? Clinical Chemistry 2024, 70: 700-702. PMID: 38498011, DOI: 10.1093/clinchem/hvae026.Peer-Reviewed Original ResearchGlycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real?
Jiao J, Bernard P, Meeusen J, Militello L, El-Khoury J. Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Clinical Chemistry 2024, 70: 703-706. PMID: 38692658, DOI: 10.1093/clinchem/hvae032.Peer-Reviewed Original ResearchBiomarkers vs Machines: The Race to Predict Acute Kidney Injury
Ghazi L, Farhat K, Hoenig M, Durant T, El-Khoury J. Biomarkers vs Machines: The Race to Predict Acute Kidney Injury. Clinical Chemistry 2024, 70: 805-819. PMID: 38299927, DOI: 10.1093/clinchem/hvad217.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAcute kidney injuryEarly diagnosisInsulin-like growth factor-binding protein 7Prediction of acute kidney injuryGrowth factor-binding protein 7Detect acute kidney injuryNeutrophil gelatinase-associated lipocalinAcute kidney injury detectionClinical practiceIrreversible kidney damageClinical outcome studiesImminent AKISerum creatinineKidney injuryInjury markersPediatric populationCystatin CTissue inhibitorHospitalized patientsClinical useKidney damageRegulatory approvalProtein 7BiomarkersOutcome studiesRenalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19
Safdar B, Sobiesk M, Bertsimas D, Nowroozpoor A, Deng Y, D’Onofrio G, Dziura J, El-Khoury J, Guo X, Simonov M, Taylor R, Wang M, Desir G. Renalase Identified by Machine Learning Methods as A Novel Independent Predictor of Mortality in Hospitalized Patients with COVID-19. Journal Of Biotechnology And Biomedicine 2024, 07 DOI: 10.26502/jbb.2642-91280139.Peer-Reviewed Original Research
2023
Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 37931733, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchUnexpected Negative Zolpidem Urine Drug Test in a Compliant Patient
Shang E, Choucair I, El-Khoury J. Unexpected Negative Zolpidem Urine Drug Test in a Compliant Patient. Clinical Chemistry 2023, 69: 1435-1436. PMID: 38037440, DOI: 10.1093/clinchem/hvad149.Peer-Reviewed Original ResearchRapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T.
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 38420909, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchConceptsRapid Serum TubesPlasma separation tubesHigh-sensitivity troponin THs-cTnT valuesHs-cTnTSource of hemolysisEmergency departmentTroponin TSerum tubesFalse positive resultsMedian reductionEffect of hemolysisED patientsSample collectionEffects of tube typeHemolysisPatientsPositive resultsSeparator tubesInternational Perspectives on GFR Estimation and Race-Based Adjustments
El-Khoury J, Karger A, Cavalier E, Kalyesubula R, Teo B, Costa e Silva V, Inker L. International Perspectives on GFR Estimation and Race-Based Adjustments. Clinical Chemistry 2023, 69: 796-802. PMID: 37453046, DOI: 10.1093/clinchem/hvad095.Peer-Reviewed Original ResearchLaboratory-developed tests: The forgotten majority
El-Khoury J. Laboratory-developed tests: The forgotten majority. American Journal Of Clinical Pathology 2023, 160: 541-541. PMID: 37449363, DOI: 10.1093/ajcp/aqad080.Peer-Reviewed Original ResearchCannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization
Tolan N, Krasowski M, Mathias P, Wiencek J, Babic N, Chai P, Chambliss A, Choucair I, Demetriou C, Erickson T, Feldhammer M, French D, Hayes B, Kang P, El-Khoury J, Knezevic C, Monte A, Nerenz R, Okorodudu A, Roper S, Saitman A, Thiriveedhi V, Uljon S, Vest A, Woodworth A, Yu M, Melanson S. Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization. Journal Of Toxicology Clinical Toxicology 2023, 61: 248-259. PMID: 37129223, PMCID: PMC10793079, DOI: 10.1080/15563650.2023.2177552.Peer-Reviewed Original ResearchHemolysis or wine? A case of red-wine-colored plasma
Malaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma. Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.Peer-Reviewed Original ResearchSeasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription
El-Khoury J. Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription. Clinical Chemistry 2023, 69: 537-538. PMID: 36857303, DOI: 10.1093/clinchem/hvad017.Peer-Reviewed Original Research