2024
Breaking the Chain: Navigating the Pitfalls of Total Laboratory Automation
El-Khoury J. Breaking the Chain: Navigating the Pitfalls of Total Laboratory Automation. The Journal Of Applied Laboratory Medicine 2024, 9: 1095-1096. PMID: 39225460, DOI: 10.1093/jalm/jfae061.Peer-Reviewed Original ResearchAutomation, LaboratoryHumansADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins
Cao J, Donato L, El-Khoury J, Goldberg A, Meeusen J, Remaley A. ADLM Guidance Document on the Measurement and Reporting of Lipids and Lipoproteins. The Journal Of Applied Laboratory Medicine 2024, 9: 1040-1056. PMID: 39225455, DOI: 10.1093/jalm/jfae057.Peer-Reviewed Original ResearchConceptsNon-HDL-CLDL-C calculationLDL-CLipid panelLipoprotein cholesterolMeasurement of blood lipidsNon-high-density lipoprotein cholesterolElevated concentration of triglyceridesLow-density lipoprotein cholesterolMeasured LDL-CAtherosclerotic disease riskLipid testingConcentrations of triglyceridesClinical managementDisease riskReporting of resultsBlood lipidsPre-analytical requirementsApolipoprotein BFasting requirementsImprove standardsGuidance documentsLipidCholesterolLipoproteinGlycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real?
Jiao J, Bernard P, Meeusen J, Militello L, El-Khoury J. Glycerol Kinase Deficiency with Increased Triglycerides and Weight Gain: Pseudo or Real? Clinical Chemistry 2024, 70: 703-706. PMID: 38692658, DOI: 10.1093/clinchem/hvae032.Peer-Reviewed Original Research
2023
Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 37931733, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchUnexpected Negative Zolpidem Urine Drug Test in a Compliant Patient
Shang E, Choucair I, El-Khoury J. Unexpected Negative Zolpidem Urine Drug Test in a Compliant Patient. Clinical Chemistry 2023, 69: 1435-1436. PMID: 38037440, DOI: 10.1093/clinchem/hvad149.Peer-Reviewed Original ResearchRapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T.
Malaeb H, Vera M, Sangal R, Venkatesh A, Possick S, Maciejak L, Oberle E, El-Khoury J. Rapid serum tubes reduce transport hemolysis and false positive rates for high-sensitivity troponin T. Clinica Chimica Acta 2023, 551: 117630. PMID: 38420909, DOI: 10.1016/j.cca.2023.117630.Peer-Reviewed Original ResearchConceptsRapid Serum TubesPlasma separation tubesHigh-sensitivity troponin THs-cTnT valuesHs-cTnTSource of hemolysisEmergency departmentTroponin TSerum tubesFalse positive resultsMedian reductionEffect of hemolysisED patientsSample collectionEffects of tube typeHemolysisPatientsPositive resultsSeparator tubesInternational Perspectives on GFR Estimation and Race-Based Adjustments
El-Khoury J, Karger A, Cavalier E, Kalyesubula R, Teo B, Costa e Silva V, Inker L. International Perspectives on GFR Estimation and Race-Based Adjustments. Clinical Chemistry 2023, 69: 796-802. PMID: 37453046, DOI: 10.1093/clinchem/hvad095.Peer-Reviewed Original ResearchLaboratory-developed tests: The forgotten majority
El-Khoury J. Laboratory-developed tests: The forgotten majority. American Journal Of Clinical Pathology 2023, 160: 541-541. PMID: 37449363, DOI: 10.1093/ajcp/aqad080.Peer-Reviewed Original ResearchForeign BodiesHumansCannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization
Tolan N, Krasowski M, Mathias P, Wiencek J, Babic N, Chai P, Chambliss A, Choucair I, Demetriou C, Erickson T, Feldhammer M, French D, Hayes B, Kang P, El-Khoury J, Knezevic C, Monte A, Nerenz R, Okorodudu A, Roper S, Saitman A, Thiriveedhi V, Uljon S, Vest A, Woodworth A, Yu M, Melanson S. Cannabis positivity rates in 17 emergency departments across the United States with varying degrees of marijuana legalization. Journal Of Toxicology Clinical Toxicology 2023, 61: 248-259. PMID: 37129223, PMCID: PMC10793079, DOI: 10.1080/15563650.2023.2177552.Peer-Reviewed Original ResearchHemolysis or wine? A case of red-wine-colored plasma
Malaeb H, Vera M, Figueroa Villalba C, El-Khoury J. Hemolysis or wine? A case of red-wine-colored plasma. Clinica Chimica Acta 2023, 542: 117277. PMID: 36870523, DOI: 10.1016/j.cca.2023.117277.Peer-Reviewed Original ResearchSeasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription
El-Khoury J. Seasonal Variation and Thyroid Function Testing: Source of Misdiagnosis and Levothyroxine Over-Prescription. Clinical Chemistry 2023, 69: 537-538. PMID: 36857303, DOI: 10.1093/clinchem/hvad017.Peer-Reviewed Original ResearchVitamin D and Bone Fractures Revisited
Malaeb H, El-Khoury J. Vitamin D and Bone Fractures Revisited. Clinical Chemistry 2023, 69: 209-209. PMID: 36724482, DOI: 10.1093/clinchem/hvac196.Peer-Reviewed Original Research
2022
A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use
Choucair I, Villalba C, Vera M, Cassella-Mclane G, Durant T, El-Khoury J. A preliminary study of hydrocodone and hydromorphone to oxycodone ratios for distinguishing impurities from independent opioid use. Clinical Biochemistry 2022, 112: 6-10. PMID: 36535386, DOI: 10.1016/j.clinbiochem.2022.12.009.Peer-Reviewed Original ResearchConceptsConcentrations of hydrocodoneMean ratioOxycodone pillsPrescription complianceOpioid useUDT resultsMedication recordsOxycodoneAdditional opiatesPatientsHydromorphoneLarger sample sizeAbstractTextHydrocodoneDrug abuseLiquid chromatography-tandem mass spectrometryDrug testingChromatography-tandem mass spectrometryLC-MS/MSFurther validationPreliminary studySample sizeOpiatesSensitive methodPillsRising to the Challenge: Shortages in Laboratory Medicine
Knezevic CE, Das B, El-Khoury JM, Jannetto PJ, Lacbawan F, Winter WE. Rising to the Challenge: Shortages in Laboratory Medicine. Clinical Chemistry 2022, 68: 1486-1492. PMID: 36301321, DOI: 10.1093/clinchem/hvac179.Peer-Reviewed Original ResearchContamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks
Choucair I, Lee ES, Vera MA, Drongmebaro C, El-Khoury JM, Durant TJS. Contamination of clinical blood samples with crystalloid solutions: An experimental approach to derive multianalyte delta checks. Clinica Chimica Acta 2022, 538: 22-28. PMID: 36309069, DOI: 10.1016/j.cca.2022.10.011.Peer-Reviewed Original ResearchConceptsWet chemistry experimentsAn Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error?
Choucair I, Cassella-Mclane G, Rogers K, Durant T, El-Khoury J. An Unusual Case of High 6-Monoacetylmorphine and Low Morphine in Urine: Heroin Abuse or Analytical Error? Clinical Chemistry 2022, 68: 1344-1345. PMID: 37619530, DOI: 10.1093/clinchem/hvac110.Peer-Reviewed Case Reports and Technical NotesResolving icteric interference by a novel photoisomerization device: Bilibox
Vera MA, Koch CD, El-Khoury JM. Resolving icteric interference by a novel photoisomerization device: Bilibox. Clinical Biochemistry 2022, 115: 112-115. PMID: 35882276, DOI: 10.1016/j.clinbiochem.2022.07.004.Peer-Reviewed Original ResearchConceptsDirect bilirubinIcteric interferenceAforementioned analytesChemical reactivityPhotoisomerizationRoutine laboratory testingEndogenous interferencesBilirubin elevationBaseline creatinineAssay reagentsLaboratory testingDilutional methodMin of treatmentCreatinineEnzymatic creatinine assayIcterusBilirubinChemistry testingClinical samplesCreatinine assaysHeparin vacutainersTreatmentAnalytesIctericRepeat measurementsPublic Misinformation and Science Communication in Times of Public Health Crises
Vera MA, El-Khoury JM, Thorp H, Tofel RJ, Ross JS, Mandavilli A, Topol E. Public Misinformation and Science Communication in Times of Public Health Crises. Clinical Chemistry 2022, 68: 1008-1014. PMID: 35675305, DOI: 10.1093/clinchem/hvac088.Commentaries, Editorials and LettersEffects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real?
Vera MA, Eid T, El-Khoury JM. Effects of Bovine Hemoglobin on Chemistry Testing: Pseudohemolysis or Real? Clinical Chemistry 2022, 68: 607-608. PMID: 36103316, DOI: 10.1093/clinchem/hvab222.Peer-Reviewed Original ResearchUnexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia
Jacobs JW, Gisriel SD, Iyer K, Hauser RG, El-Khoury JM. Unexpectedly low hemoglobin A1c in a patient with chronic lymphocytic leukemia. Clinica Chimica Acta 2022, 531: 91-93. PMID: 35351433, DOI: 10.1016/j.cca.2022.03.012.Peer-Reviewed Original ResearchConceptsChronic lymphocytic leukemiaNeoplastic lymphocytesLymphocytic leukemiaDiabetes mellitus type 2Red blood cell survivalMellitus type 2Blood cell survivalGlycated hemoglobin assaysCertain medicationsLower hemoglobinHemolytic anemiaType 2PatientsHemoglobin assayPrecise mechanismMarked numberLymphocytesLeukemiaCell survivalFurther investigationHemoglobin variantsAssaysMedicationsAnemiaEnzymatic assay