2023
International Perspectives on GFR Estimation and Race-Based Adjustments
El-Khoury J, Karger A, Cavalier E, Kalyesubula R, Teo B, Costa e Silva V, Inker L. International Perspectives on GFR Estimation and Race-Based Adjustments. Clinical Chemistry 2023, 69: 796-802. PMID: 37453046, DOI: 10.1093/clinchem/hvad095.Peer-Reviewed Original Research
2022
Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes
Chen T, Coca S, Thiessen-Philbrook H, Heerspink H, Obeid W, Ix J, Fried L, Bonventre J, El-Khoury J, Shlipak M, Parikh C. Urinary Biomarkers of Tubular Health and Risk for Kidney Function Decline or Mortality in Diabetes. American Journal Of Nephrology 2022, 53: 775-785. PMID: 36630924, PMCID: PMC10006337, DOI: 10.1159/000528918.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersChitinase-3-Like Protein 1Diabetes MellitusGlomerular Filtration RateHumansInterleukin-18KidneyKidney Failure, ChronicLipocalin-2Renal Insufficiency, ChronicConceptsKidney function declineEnd-stage kidney diseaseFunction declineMCP-1Tubular healthUrinary biomarkersEGFR declineKIM-1YKL-40High riskChronic kidney disease progressionSubsequent eGFR declineKidney disease progressionGlomerular filtration rateYKL-40 levelsAvailable urine samplesOne-year changeHigher baseline levelsSubset of participantsBaseline UACRMedian UACRCause mortalityUrine albuminTubular injuryCreatinine ratio
2021
Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations
Moderators:, El-Khoury JM, Ovalle AA, Cervinski MA, Experts:, Levey AS, Jones G, Eneanya ND, Lieske JC, Jha V. Is It Time to Move On? Reexamining Race in Glomerular Filtration Rate Equations. Clinical Chemistry 2021, 67: 585-591. PMID: 33686430, DOI: 10.1093/clinchem/hvaa333.Peer-Reviewed Original Research
2020
Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes.
Mansour SG, Liu C, Jia Y, Reese PP, Hall IE, El-Achkar TM, LaFavers KA, Obeid W, Rosenberg AZ, Daneshpajouhnejad P, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Schröppel B, Singh P, El-Khoury JM, Weng FL, Thiessen-Philbrook HR, Parikh CR. Uromodulin to Osteopontin Ratio in Deceased Donor Urine Is Associated With Kidney Graft Outcomes. Transplantation 2020, 105: 876-885. PMID: 32769629, PMCID: PMC8805736, DOI: 10.1097/tp.0000000000003299.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsBiomarkersCells, CulturedDelayed Graft FunctionFemaleGlomerular Filtration RateGraft SurvivalHistocompatibility Antigens Class IIHumansKidneyKidney TransplantationMacrophagesMaleMiceMiddle AgedOsteopontinProspective StudiesRisk AssessmentRisk FactorsTime FactorsTissue DonorsUnited StatesUromodulinConceptsGraft failureGraft functionGraft outcomePrimary outcomeMajor histocompatibilityDeath-censored graft failureDeceased donor kidney transplantationCause graft failureImproved graft survivalRecipient graft outcomesKidney graft outcomeGlomerular filtration rateDeceased donor kidneysTime of procurementGraft survivalKidney transplantationDirection of associationDeceased donorsFiltration rateKidney qualityLower riskExtensive injuryDonor urineSimilar associationMouse macrophages
2016
Comparison of symmetric dimethylarginine with creatinine, cystatin C and their eGFR equations as markers of kidney function
El-Khoury JM, Bunch DR, Hu B, Payto D, Reineks EZ, Wang S. Comparison of symmetric dimethylarginine with creatinine, cystatin C and their eGFR equations as markers of kidney function. Clinical Biochemistry 2016, 49: 1140-1143. PMID: 27452178, DOI: 10.1016/j.clinbiochem.2016.07.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedArginineBiomarkersCreatinineCystatin CFemaleGlomerular Filtration RateHumansKidney Function TestsMaleMiddle AgedYoung AdultConceptsGlomerular filtration rateKidney functionCystatin CEGFR equationsWidespread clinical useIothalamate clearanceEGFR formulasFiltration rateSymmetric dimethylargininePlasma specimensAdult populationStrong markerAbstractTextClinical useEndogenous markerCreatinineLiquid chromatography-tandem mass spectrometry methodChromatography-tandem mass spectrometry methodFurther studiesDimethylarginineRoche Cobas 8000MarkersCatabolic productsCobas 8000
2014
Measurement of GFR for children and an LC–MS/MS method for nonradioactive iothalamate
El-Khoury JM, Gabler J, Wang S. Measurement of GFR for children and an LC–MS/MS method for nonradioactive iothalamate. Clinical Biochemistry 2014, 47: 749-750. PMID: 24858210, DOI: 10.1016/j.clinbiochem.2014.05.042.Peer-Reviewed Original Research