2017
DNA repair and systemic lupus erythematosus
Meas R, Burak MJ, Sweasy JB. DNA repair and systemic lupus erythematosus. DNA Repair 2017, 56: 174-182. PMID: 28623091, PMCID: PMC5543809, DOI: 10.1016/j.dnarep.2017.06.020.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusDevelopment of lupusLupus erythematosusGenetic predispositionChronic autoimmune diseaseAutoimmune diseasesMonozygotic twin concordanceFamilial aggregation studiesImmune systemLupusPotential associationCommon risk allelesRisk allelesDNA repair genesEnvironmental exposuresAberrant DNA repairErythematosusDNA repairTwin concordanceRepair genesCurrent knowledgeRepairAggregation studiesPredispositionDisease
2014
Mutation of POLB Causes Lupus in Mice
Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB. Mutation of POLB Causes Lupus in Mice. Cell Reports 2014, 6: 1-8. PMID: 24388753, PMCID: PMC3916967, DOI: 10.1016/j.celrep.2013.12.017.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus-like diseaseLupus erythematosusAutoimmune pathologyMouse modelGenome-wide association studiesPol β activityDecreased expressionMutant miceUnderlying causeMicePrevious genome-wide association studyΒ activityDNA polymerase activityReplication studyExcision repair pathwayImmune diversitySomatic hypermutationBase excision repair pathwayAssociation studiesErythematosusLupusPolymerase activityExpressionKey enzyme