Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice
Weerachayaphorn J, Luo Y, Mennone A, Soroka CJ, Harry K, Boyer JL. Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice. Journal Of Hepatology 2013, 60: 160-166. PMID: 23978715, PMCID: PMC4054607, DOI: 10.1016/j.jhep.2013.08.015.Peer-Reviewed Original ResearchConceptsBile duct ligationBDL miceLiver injuryControl miceBile duct-ligated miceBile flow rateBile duct obstructionHepato-protective effectsSmooth muscle actin expressionLiver function markersSevere liver damageBile acid-independent flowHigher bile flowMatrix metalloproteinases-9Hepatic stellate cellsCancer preventive agentsMuscle actin expressionPromising cancer-preventive agentBiliary pressureSerum aminotransferasesLiver histologyBDL groupPhase II detoxificationPortal fibroblastsProfibrogenic genesAlleviative effect of andrographolide on alpha‐naphthylisothiocyanate‐induced cholestatic liver injury in rats
Khamphaya T, Piyachaturawat P, Weerachayaphorn J. Alleviative effect of andrographolide on alpha‐naphthylisothiocyanate‐induced cholestatic liver injury in rats. The FASEB Journal 2013, 27: 1161.2-1161.2. DOI: 10.1096/fasebj.27.1_supplement.1161.2.Peer-Reviewed Original ResearchLiver injuryMonocyte chemoattractant protein-1Severe liver inflammationCholestatic liver damageCholestatic liver injuryBile duct proliferationChemoattractant protein-1Tumor necrosis factorPotential therapeutic actionNF-kB signalingGamma-glutamyl transpeptidaseLiver inflammationSerum aminotransferasesLiver failureLiver diseaseDuct proliferationLiver damageHepatoprotective effectMajor active compoundNecrosis factorHepatic accumulationNF-kBAndrographolide pretreatmentANITBile acids